PLCB4 (phospholipase C, beta 4)

Identity

Other names	FLJ16169
	PI-PLC
HGNC	PLCB4
Location	20p12
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	PLCB4   9059
Entrez_Gene	PLCB4  5332  phospholipase C, beta 4
	Cards
GeneCards	PLCB4
Ensembl	PLCB4 [Search_View]   ENSG00000101333 [Gene_View]
Genatlas	PLCB4
GeneLynx	PLCB4
eGenome	PLCB4
euGene	5332
	Genomic and cartography
GoldenPath	PLCB4  -  20p12   chr20:9024932-9409462 +  20p12.2   [Description]    (hg18-March_2006)
Ensembl	PLCB4 - 20p12.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	PLCB4
	Gene and transcription
Genbank	AK025027 [ ENTREZ ]
Genbank	AK054754 [ ENTREZ ]
Genbank	AK057634 [ ENTREZ ]
Genbank	AK122699 [ ENTREZ ]
Genbank	AK307482 [ ENTREZ ]
RefSeq	NM_000933 [ SRS ]    NM_000933 [ ENTREZ ]
RefSeq	NM_182797 [ SRS ]    NM_182797 [ ENTREZ ]
RefSeq	AC_000063 [ SRS ]    AC_000063 [ ENTREZ ]
RefSeq	AC_000152 [ SRS ]    AC_000152 [ ENTREZ ]
RefSeq	NC_000020 [ SRS ]    NC_000020 [ ENTREZ ]
RefSeq	NT_011387 [ SRS ]    NT_011387 [ ENTREZ ]
RefSeq	NW_001838652 [ SRS ]    NW_001838652 [ ENTREZ ]
RefSeq	NW_927317 [ SRS ]    NW_927317 [ ENTREZ ]
AceView	PLCB4 AceView - NCBI
Unigene	Hs.472101 [ SRS ]    Hs.472101 [ NCBI ]     HS472101 [ spliceNest ]
Fast-db	5406 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q15147 [ SRS]    Q15147 [ EXPASY ]     Q15147 [ INTERPRO ]     Q15147 [ UNIPROT ]
Prosite	PS50004 C2 [ SRS ]    PS50004 C2 [ Expasy ]
Prosite	PS50007 PIPLC_X_DOMAIN [ SRS ]    PS50007 PIPLC_X_DOMAIN [ Expasy ]
Prosite	PS50008 PIPLC_Y_DOMAIN [ SRS ]    PS50008 PIPLC_Y_DOMAIN [ Expasy ]
Interpro	IPR000008 C2_Ca-dep [ SRS ]    IPR000008 C2_Ca-dep [ EBI ]
Interpro	IPR009535 DUF1154 [ SRS ]    IPR009535 DUF1154 [ EBI ]
Interpro	IPR011992 EF-Hand_type [ SRS ]    IPR011992 EF-Hand_type [ EBI ]
Interpro	IPR015359 Phospholipase_C_EF-hand-like [ SRS ]    IPR015359 Phospholipase_C_EF-hand-like [ EBI ]
Interpro	IPR001192 Phospholipase_C_Pinositol-sp_C [ SRS ]    IPR001192 Phospholipase_C_Pinositol-sp_C [ EBI ]
Interpro	IPR000909 Phospholipase_C_Pinositol-sp_X [ SRS ]    IPR000909 Phospholipase_C_Pinositol-sp_X [ EBI ]
Interpro	IPR001711 Phospholipase_C_Pinositol-sp_Y [ SRS ]    IPR001711 Phospholipase_C_Pinositol-sp_Y [ EBI ]
Interpro	IPR016280 PLC-beta [ SRS ]    IPR016280 PLC-beta [ EBI ]
CluSTr	Q15147
Pfam	PF00168 C2 [ SRS ]    PF00168 C2 [ Sanger ]    pfam00168 [ NCBI-CDD ]
Pfam	PF06631 DUF1154 [ SRS ]    PF06631 DUF1154 [ Sanger ]    pfam06631 [ NCBI-CDD ]
Pfam	PF09279 efhand_like [ SRS ]    PF09279 efhand_like [ Sanger ]    pfam09279 [ NCBI-CDD ]
Pfam	PF00388 PI-PLC-X [ SRS ]    PF00388 PI-PLC-X [ Sanger ]    pfam00388 [ NCBI-CDD ]
Pfam	PF00387 PI-PLC-Y [ SRS ]    PF00387 PI-PLC-Y [ Sanger ]    pfam00387 [ NCBI-CDD ]
Smart	SM00239 C2 [EMBL]
Smart	SM00148 PLCXc [EMBL]
Smart	SM00149 PLCYc [EMBL]
Prodom	PD001202 PI_PLC_Y[INRA-Toulouse]
Prodom	Q15147 PLCB4_HUMAN [ Domain structure ]   Q15147 PLCB4_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	Q15147
HPRD	02885
	Protein Interaction databases
DIP	Q15147
IntAct	Q15147
	Polymorphism : SNP, mutations, diseases
OMIM	600810    [ map ]
GENECLINICS	600810
SNP	PLCB4 [dbSNP-NCBI]
SNP	NM_000933 [SNP-NCI]
SNP	NM_182797 [SNP-NCI]
SNP	PLCB4 [GeneSNPs - Utah]  PLCB4] [HGBASE - SRS]
HAPMAP	PLCB4 [HAPMAP]
COSMIC	PLCB4 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	PLCB4
	General knowledge
Family Browser	PLCB4 [UCSC Family Browser]
SOURCE	NM_000933
SOURCE	NM_182797
SMD	Hs.472101
SAGE	Hs.472101
Enzyme	3.1.4.11 [ Enzyme-Expasy ]   3.1.4.11 [ Enzyme-SRS ]   3.1.4.11 [ IntEnz-EBI ]   3.1.4.11 [ BRENDA ]   3.1.4.11 [ KEGG ]   3.1.4.11 [ WIT ]
GO	phosphoinositide phospholipase C activity [Amigo]  phosphoinositide phospholipase C activity
GO	signal transducer activity [Amigo]  signal transducer activity
GO	calcium ion binding [Amigo]  calcium ion binding
GO	protein binding [Amigo]  protein binding
GO	lipid metabolic process [Amigo]  lipid metabolic process
GO	intracellular signaling cascade [Amigo]  intracellular signaling cascade
GO	lipid catabolic process [Amigo]  lipid catabolic process
GO	hydrolase activity [Amigo]  hydrolase activity
KEGG	Inositol phosphate metabolism
KEGG	Calcium signaling pathway
KEGG	Phosphatidylinositol signaling system
KEGG	Wnt signaling pathway
KEGG	Gap junction
KEGG	Long-term potentiation
KEGG	Long-term depression
KEGG	GnRH signaling pathway
PubGene	PLCB4
TreeFam	PLCB4
CTD	5332 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	PLCB4 Related clones (RZPD - Berlin)
	PubMed
PubMed	15 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:25:12 2008