PLK3 (polo like kinase 3)

2003-06-01  

Identity

HGNC
LOCATION
1p34.1
LOCUSID
ALIAS
CNK,FNK,PLK-3,PRK
FUSION GENES

Other Information

Locus ID:

NCBI: 1263
MIM: 602913
HGNC: 2154
Ensembl: ENSG00000173846

Variants:

dbSNP: 1263
ClinVar: 1263
TCGA: ENSG00000173846
COSMIC: PLK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173846ENST00000372201Q9H4B4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
FoxO signaling pathwayKEGGhsa04068
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainREACTOMER-HSA-6804115
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
119317602002The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase.161
225494662012Threonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongation.68
122426612002Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways.47
263843502015Long noncoding RNA HOXA-AS2 promotes gastric cancer proliferation by epigenetically silencing P21/PLK3/DDIT3 expression.44
119719762002Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity.41
172642062007Polo-like kinase 3 is required for entry into S phase.37
252672942014Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1.34
208895022010Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha.30
164787332006Polo box domain of Plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects, and apoptosis.27
191037562009Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation.24

Citation

Dessen P

PLK3 (polo like kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41748/plk3