POLA1 (polymerase (DNA directed), alpha 1)

Identity

Other names	DKFZp686K1672
	POLA
Hugo	POLA1
Location	Xp22.1-p21.3
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

External links

	Nomenclature
Hugo	POLA1
GDB	POLA1
Entrez_Gene	POLA1  5422  polymerase (DNA directed), alpha 1
	Cards
GeneCards	POLA1
Ensembl	POLA1 [Search_View]   ENSG00000101868 [Gene_View]
Genatlas	POLA1
GeneLynx	POLA1
eGenome	POLA1
euGene	5422
	Genomic and cartography
GoldenPath	POLA1  -     chrX:24621977-24925021 +  Xp22.11   [Description]    (hg18-March_2006)
Ensembl	POLA1 - Xp22.11 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	POLA1
	Gene and transcription
Genbank	BU508486 [ ENTREZ ]
Genbank	BX648513 [ ENTREZ ]
Genbank	CR625340 [ ENTREZ ]
Genbank	DW462890 [ ENTREZ ]
Genbank	X06745 [ ENTREZ ]
RefSeq	NM_016937 [ SRS ]    NM_016937 [ ENTREZ ]
RefSeq	AC_000066 [ SRS ]    AC_000066 [ ENTREZ ]
RefSeq	NC_000023 [ SRS ]    NC_000023 [ ENTREZ ]
RefSeq	NT_011757 [ SRS ]    NT_011757 [ ENTREZ ]
RefSeq	NW_927700 [ SRS ]    NW_927700 [ ENTREZ ]
AceView	POLA1 AceView - NCBI
Unigene	Hs.567319 [ SRS ]    Hs.567319 [ NCBI ]     HS567319 [ spliceNest ]
Fast-db	4592 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P09884 [ SRS]    P09884 [ EXPASY ]     P09884 [ INTERPRO ]
Prosite	PS00116 DNA_POLYMERASE_B [ SRS ]    PS00116 DNA_POLYMERASE_B [ Expasy ]
Interpro	IPR004578 DNA_pol2 [ SRS ]    IPR004578 DNA_pol2 [ EBI ]
Interpro	IPR006172 DNA_pol_B [ SRS ]    IPR006172 DNA_pol_B [ EBI ]
Interpro	IPR006133 DNA_pol_B_exo [ SRS ]    IPR006133 DNA_pol_B_exo [ EBI ]
Interpro	IPR006134 DNA_pol_B_region [ SRS ]    IPR006134 DNA_pol_B_region [ EBI ]
Interpro	IPR015088 Znf_DNA_pol_a [ SRS ]    IPR015088 Znf_DNA_pol_a [ EBI ]
CluSTr	P09884
Pfam	PF00136 DNA_pol_B [ SRS ]    PF00136 DNA_pol_B [ Sanger ]    pfam00136 [ NCBI-CDD ]
Pfam	PF03104 DNA_pol_B_exo [ SRS ]    PF03104 DNA_pol_B_exo [ Sanger ]    pfam03104 [ NCBI-CDD ]
Pfam	PF08996 zf-DNA_Pol [ SRS ]    PF08996 zf-DNA_Pol [ Sanger ]    pfam08996 [ NCBI-CDD ]
Smart	SM00486 POLBc [EMBL]
Blocks	P09884
PDB	1K0P [ SRS ]    1K0P [ PdbSum ],   1K0P [ IMB ]   1K0P [ RSDB ]
PDB	1K18 [ SRS ]    1K18 [ PdbSum ],   1K18 [ IMB ]   1K18 [ RSDB ]
PDB	1N5G [ SRS ]    1N5G [ PdbSum ],   1N5G [ IMB ]   1N5G [ RSDB ]
HPRD	02416
	Protein Interaction databases
DIP	P09884
IntAct	P09884
	Polymorphism : SNP, mutations, diseases
OMIM	312040    [ map ]
GENECLINICS	312040
SNP	POLA1 [dbSNP-NCBI]
SNP	NM_016937 [SNP-NCI]
SNP	POLA1 [GeneSNPs - Utah]  POLA1] [HGBASE - SRS]
HAPMAP	POLA1 [HAPMAP]
COSMIC	POLA1 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	POLA1
	General knowledge
Family Browser	POLA1 [UCSC Family Browser]
SOURCE	NM_016937
SMD	Hs.567319
SAGE	Hs.567319
Enzyme	2.7.7.7 [ Enzyme-SRS ]   2.7.7.7 [ Brenda-SRS ]   2.7.7.7 [ KEGG ]   2.7.7.7 [ WIT ]
GO	S phase of mitotic cell cycle [Amigo]  S phase of mitotic cell cycle
GO	nucleotide binding [Amigo]  nucleotide binding
GO	DNA synthesis during DNA repair [Amigo]  DNA synthesis during DNA repair
GO	DNA synthesis during DNA repair [Amigo]  DNA synthesis during DNA repair
GO	chromatin [Amigo]  chromatin
GO	DNA binding [Amigo]  DNA binding
GO	DNA binding [Amigo]  DNA binding
GO	chromatin binding [Amigo]  chromatin binding
GO	alpha DNA polymerase activity [Amigo]  alpha DNA polymerase activity
GO	alpha DNA polymerase activity [Amigo]  alpha DNA polymerase activity
GO	DNA primase activity [Amigo]  DNA primase activity
GO	protein binding [Amigo]  protein binding
GO	sugar binding [Amigo]  sugar binding
GO	nucleus [Amigo]  nucleus
GO	nuclear envelope [Amigo]  nuclear envelope
GO	nucleoplasm [Amigo]  nucleoplasm
GO	alpha DNA polymerase:primase complex [Amigo]  alpha DNA polymerase:primase complex
GO	alpha DNA polymerase:primase complex [Amigo]  alpha DNA polymerase:primase complex
GO	nucleolus [Amigo]  nucleolus
GO	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [Amigo]  nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO	DNA replication initiation [Amigo]  DNA replication initiation
GO	leading strand elongation [Amigo]  leading strand elongation
GO	lagging strand elongation [Amigo]  lagging strand elongation
GO	double-strand break repair via nonhomologous end joining [Amigo]  double-strand break repair via nonhomologous end joining
GO	zinc ion binding [Amigo]  zinc ion binding
GO	cell proliferation [Amigo]  cell proliferation
GO	response to pH [Amigo]  response to pH
GO	response to virus [Amigo]  response to virus
GO	nuclear matrix [Amigo]  nuclear matrix
GO	transferase activity [Amigo]  transferase activity
GO	nucleotidyltransferase activity [Amigo]  nucleotidyltransferase activity
GO	metal ion binding [Amigo]  metal ion binding
KEGG	Purine metabolism
KEGG	Pyrimidine metabolism
KEGG	DNA polymerase
PubGene	POLA1
TreeFam	POLA1
CTD	5422 [Comparative Genomics Database]
	Other databases
	Probes
Probe	POLA1 Related clones (RZPD - Berlin)
	PubMed
PubMed	49 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu May 22 20:22:22 2008