POMC (proopiomelanocortin)

Identity

Other names	ACTH
	CLIP
	LPH
	MSH
	NPP
	POC
HGNC	POMC
Location	2p23
Location_base_pair	Starts at 25237226 and ends at 25245063 bp from pter (hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	POMC   9201
Entrez_Gene	POMC  5443  proopiomelanocortin
	Cards
GeneCards	POMC
Ensembl	POMC [Search_View]   ENSG00000115138 [Gene_View]
Genatlas	POMC
GeneLynx	POMC
eGenome	POMC
euGene	5443
	Genomic and cartography
GoldenPath	POMC  -  2p23   chr2:25237226-25245063 -  2p23.3   [Description]    (hg18-March_2006)
Ensembl	POMC - 2p23.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	POMC
	Gene and transcription
Genbank	AI341269 [ ENTREZ ]
Genbank	AW951218 [ ENTREZ ]
Genbank	BC065832 [ ENTREZ ]
Genbank	BT019918 [ ENTREZ ]
Genbank	CB988233 [ ENTREZ ]
RefSeq	NM_000939 [ SRS ]    NM_000939 [ ENTREZ ]
RefSeq	NM_001035256 [ SRS ]    NM_001035256 [ ENTREZ ]
RefSeq	AC_000045 [ SRS ]    AC_000045 [ ENTREZ ]
RefSeq	AC_000134 [ SRS ]    AC_000134 [ ENTREZ ]
RefSeq	NC_000002 [ SRS ]    NC_000002 [ ENTREZ ]
RefSeq	NT_022184 [ SRS ]    NT_022184 [ ENTREZ ]
RefSeq	NW_001838768 [ SRS ]    NW_001838768 [ ENTREZ ]
RefSeq	NW_927719 [ SRS ]    NW_927719 [ ENTREZ ]
AceView	POMC AceView - NCBI
Unigene	Hs.1897 [ SRS ]    Hs.1897 [ NCBI ]     HS1897 [ spliceNest ]
Fast-db	2228 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P01189 [ SRS]    P01189 [ EXPASY ]     P01189 [ INTERPRO ]     P01189 [ UNIPROT ]
Interpro	IPR001941 Mcortin_ACTH [ SRS ]    IPR001941 Mcortin_ACTH [ EBI ]
Interpro	IPR013533 Mcortin_ACTH_C [ SRS ]    IPR013533 Mcortin_ACTH_C [ EBI ]
Interpro	IPR013531 Mcrtin_ACTH_cent [ SRS ]    IPR013531 Mcrtin_ACTH_cent [ EBI ]
Interpro	IPR013593 Melanocortin_N [ SRS ]    IPR013593 Melanocortin_N [ EBI ]
Interpro	IPR013532 Opioid_neuropept [ SRS ]    IPR013532 Opioid_neuropept [ EBI ]
CluSTr	P01189
Pfam	PF00976 ACTH_domain [ SRS ]    PF00976 ACTH_domain [ Sanger ]    pfam00976 [ NCBI-CDD ]
Pfam	PF08384 NPP [ SRS ]    PF08384 NPP [ Sanger ]    pfam08384 [ NCBI-CDD ]
Pfam	PF08035 Op_neuropeptide [ SRS ]    PF08035 Op_neuropeptide [ Sanger ]    pfam08035 [ NCBI-CDD ]
Prodom	PD003250 Mcortin_ACTH[INRA-Toulouse]
Prodom	P01189 COLI_HUMAN [ Domain structure ]   P01189 COLI_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P01189
HPRD	01462
	Protein Interaction databases
DIP	P01189
IntAct	P01189
	Polymorphism : SNP, mutations, diseases
OMIM	176830;609830    [ map ]
GENECLINICS	176830;609830
SNP	POMC [dbSNP-NCBI]
SNP	NM_000939 [SNP-NCI]
SNP	NM_001035256 [SNP-NCI]
SNP	POMC [GeneSNPs - Utah]  POMC] [HGBASE - SRS]
HAPMAP	POMC [HAPMAP]
HGMD	POMC
	General knowledge
Family Browser	POMC [UCSC Family Browser]
SOURCE	NM_000939
SOURCE	NM_001035256
SMD	Hs.1897
SAGE	Hs.1897
GO	hormone activity [Amigo]  hormone activity
GO	hormone activity [Amigo]  hormone activity
GO	extracellular region [Amigo]  extracellular region
GO	soluble fraction [Amigo]  soluble fraction
GO	generation of precursor metabolites and energy [Amigo]  generation of precursor metabolites and energy
GO	signal transduction [Amigo]  signal transduction
GO	neuropeptide signaling pathway [Amigo]  neuropeptide signaling pathway
GO	cell-cell signaling [Amigo]  cell-cell signaling
GO	regulation of blood pressure [Amigo]  regulation of blood pressure
GO	secretory granule [Amigo]  secretory granule
BIOCARTA	Antigen Processing and Presentation    [Genes]
KEGG	Neuroactive ligand-receptor interaction
KEGG	Adipocytokine signaling pathway
PubGene	POMC
TreeFam	POMC
CTD	5443 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	POMC Related clones (RZPD - Berlin)
	PubMed
PubMed	131 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 11 13:26:37 2008