PPARGC1A (peroxisome proliferator-activated receptor gamma, coactivator 1 alpha)

Identity

Other names	LEM6
	PGC-1(alpha)
	PGC-1v
	PGC1
	PGC1A
	PPARGC1
Hugo	PPARGC1A
Location	4p15.1
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
Hugo	PPARGC1A
GDB	PPARGC1A
Entrez_Gene	PPARGC1A  10891  peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
	Cards
GeneCards	PPARGC1A
Ensembl	PPARGC1A [Search_View]   ENSG00000109819 [Gene_View]
Genatlas	PPARGC1A
GeneLynx	PPARGC1A
eGenome	PPARGC1A
euGene	10891
	Genomic and cartography
GoldenPath	PPARGC1A  -  4p15.1   chr4:23402743-23500798 -  4p15.2   [Description]    (hg18-March_2006)
Ensembl	PPARGC1A - 4p15.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	PPARGC1A
	Gene and transcription
Genbank	AB061325 [ ENTREZ ]
Genbank	AF106698 [ ENTREZ ]
Genbank	AF159714 [ ENTREZ ]
Genbank	AF186379 [ ENTREZ ]
Genbank	AK024990 [ ENTREZ ]
RefSeq	NM_013261 [ SRS ]    NM_013261 [ ENTREZ ]
RefSeq	AC_000047 [ SRS ]    AC_000047 [ ENTREZ ]
RefSeq	NC_000004 [ SRS ]    NC_000004 [ ENTREZ ]
RefSeq	NT_006316 [ SRS ]    NT_006316 [ ENTREZ ]
RefSeq	NW_922073 [ SRS ]    NW_922073 [ ENTREZ ]
AceView	PPARGC1A AceView - NCBI
Unigene	Hs.527078 [ SRS ]    Hs.527078 [ NCBI ]     HS527078 [ spliceNest ]
Fast-db	2969 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q9UBK2 [ SRS]    Q9UBK2 [ EXPASY ]     Q9UBK2 [ INTERPRO ]
Prosite	PS50102 RRM [ SRS ]    PS50102 RRM [ Expasy ]
Interpro	IPR012677 a_b_plait_nuc_bd [ SRS ]    IPR012677 a_b_plait_nuc_bd [ EBI ]
Interpro	IPR000504 RRM_RNP1 [ SRS ]    IPR000504 RRM_RNP1 [ EBI ]
CluSTr	Q9UBK2
Pfam	PF00076 RRM_1 [ SRS ]    PF00076 RRM_1 [ Sanger ]    pfam00076 [ NCBI-CDD ]
Smart	SM00360 RRM [EMBL]
Blocks	Q9UBK2
PDB	1XB7 [ SRS ]    1XB7 [ PdbSum ],   1XB7 [ IMB ]   1XB7 [ RSDB ]
HPRD	05155
	Protein Interaction databases
DIP	Q9UBK2
IntAct	Q9UBK2
	Polymorphism : SNP, mutations, diseases
OMIM	604517    [ map ]
GENECLINICS	604517
SNP	PPARGC1A [dbSNP-NCBI]
SNP	NM_013261 [SNP-NCI]
SNP	PPARGC1A [GeneSNPs - Utah]  PPARGC1A] [HGBASE - SRS]
HAPMAP	PPARGC1A [HAPMAP]
COSMIC	PPARGC1A [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	PPARGC1A
	General knowledge
Family Browser	PPARGC1A [UCSC Family Browser]
SOURCE	NM_013261
SMD	Hs.527078
SAGE	Hs.527078
GO	nucleotide binding [Amigo]  nucleotide binding
GO	thermoregulation [Amigo]  thermoregulation
GO	cell glucose homeostasis [Amigo]  cell glucose homeostasis
GO	DNA binding [Amigo]  DNA binding
GO	RNA binding [Amigo]  RNA binding
GO	nucleus [Amigo]  nucleus
GO	DNA-directed RNA polymerase II, core complex [Amigo]  DNA-directed RNA polymerase II, core complex
GO	gluconeogenesis [Amigo]  gluconeogenesis
GO	electron transport [Amigo]  electron transport
GO	transcription [Amigo]  transcription
GO	transcription initiation from RNA polymerase II promoter [Amigo]  transcription initiation from RNA polymerase II promoter
GO	mRNA processing [Amigo]  mRNA processing
GO	protein complex assembly [Amigo]  protein complex assembly
GO	mitochondrion organization and biogenesis [Amigo]  mitochondrion organization and biogenesis
GO	digestion [Amigo]  digestion
GO	transcription factor binding [Amigo]  transcription factor binding
GO	RNA splicing [Amigo]  RNA splicing
GO	RNA polymerase II transcription mediator activity [Amigo]  RNA polymerase II transcription mediator activity
GO	fatty acid oxidation [Amigo]  fatty acid oxidation
GO	ligand-dependent nuclear receptor transcription coactivator activity [Amigo]  ligand-dependent nuclear receptor transcription coactivator activity
GO	androgen receptor signaling pathway [Amigo]  androgen receptor signaling pathway
GO	positive regulation of histone acetylation [Amigo]  positive regulation of histone acetylation
GO	response to starvation [Amigo]  response to starvation
GO	cellular respiration [Amigo]  cellular respiration
GO	positive regulation of gluconeogenesis [Amigo]  positive regulation of gluconeogenesis
GO	positive regulation of transcription from RNA polymerase II promoter [Amigo]  positive regulation of transcription from RNA polymerase II promoter
GO	positive regulation of fatty acid oxidation [Amigo]  positive regulation of fatty acid oxidation
GO	androgen receptor binding [Amigo]  androgen receptor binding
GO	protein stabilization [Amigo]  protein stabilization
GO	brown fat cell differentiation [Amigo]  brown fat cell differentiation
BIOCARTA	CARM1 and Regulation of the Estrogen Receptor    [Genes]
BIOCARTA	Regulation of PGC-1a    [Genes]
BIOCARTA	Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)    [Genes]
BIOCARTA	Role of PPAR-gamma Coactivators in Obesity and Thermogenesis    [Genes]
KEGG	Insulin signaling pathway
KEGG	Adipocytokine signaling pathway
PubGene	PPARGC1A
TreeFam	PPARGC1A
CTD	10891 [Comparative Genomics Database]
	Other databases
	Probes
Probe	PPARGC1A Related clones (RZPD - Berlin)
	PubMed
PubMed	120 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu May 22 20:22:42 2008