PPP2R2A (protein phosphatase 2 regulatory subunit Balpha)

2003-11-01  

Identity

HGNC
LOCATION
8p21.2
LOCUSID
ALIAS
B55A,B55ALPHA,PR52A,PR55A,PR55alpha
FUSION GENES

Other Information

Locus ID:

NCBI: 5520
MIM: 604941
HGNC: 9304
Ensembl: ENSG00000221914

Variants:

dbSNP: 5520
ClinVar: 5520
TCGA: ENSG00000221914
COSMIC: PPP2R2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000221914ENST00000315985P63151
ENSG00000221914ENST00000380737P63151
ENSG00000221914ENST00000380737A0A140VJT0
ENSG00000221914ENST00000518254E5RJV2
ENSG00000221914ENST00000518397E5RIY1
ENSG00000221914ENST00000520329E5RHQ2
ENSG00000221914ENST00000521557E5RJV1
ENSG00000221914ENST00000524169E5RFR9
ENSG00000221914ENST00000660435A0A590UJJ1
ENSG00000221914ENST00000665949A0A590UJY3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1 PhaseREACTOMER-HSA-69236
Cyclin D associated events in G1REACTOMER-HSA-69231
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Cyclin A/B1 associated events during G2/M transitionREACTOMER-HSA-69273
M PhaseREACTOMER-HSA-68886
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Nuclear Envelope ReassemblyREACTOMER-HSA-2995410
Initiation of Nuclear Envelope ReformationREACTOMER-HSA-2995383

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
207111812010Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells.150
165808872006PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation.148
170554352006Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins.88
119561892002Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest.72
263109062015Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A.62
162392302005Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes.51
195562392009PR55 alpha, a regulatory subunit of PP2A, specifically regulates PP2A-mediated beta-catenin dephosphorylation.49
186706472008Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer.48
164748502006Complex regulation of human androgen receptor expression by Wnt signaling in prostate cancer cells.47
230870572012Loss of PPP2R2A inhibits homologous recombination DNA repair and predicts tumor sensitivity to PARP inhibition.46

Citation

Dessen P

PPP2R2A (protein phosphatase 2 regulatory subunit Balpha)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41815/ppp2r2a