PPP2R2C (protein phosphatase 2 regulatory subunit Bgamma)

2007-04-01  

Identity

HGNC
LOCATION
4p16.1
LOCUSID
ALIAS
B55-GAMMA,B55gamma,IMYPNO,IMYPNO1,PR52,PR55G
FUSION GENES

Other Information

Locus ID:

NCBI: 5522
MIM: 605997
HGNC: 9306
Ensembl: ENSG00000074211

Variants:

dbSNP: 5522
ClinVar: 5522
TCGA: ENSG00000074211
COSMIC: PPP2R2C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000074211ENST00000335585Q9Y2T4
ENSG00000074211ENST00000382599Q9Y2T4
ENSG00000074211ENST00000506140Q9Y2T4
ENSG00000074211ENST00000507294Q9Y2T4
ENSG00000074211ENST00000509917D6R943
ENSG00000074211ENST00000515571Q9Y2T4

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
197349002009Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.167
149984892004Identification of specific PP2A complexes involved in human cell transformation.115
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
180698972007A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRC.19
234932672013PPP2R2C loss promotes castration-resistance and is associated with increased prostate cancer-specific mortality.18
203089912011Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders.14
206012602010PPP2R2C, a gene disrupted in autosomal dominant intellectual disability.11
241260602013Over expression of PPP2R2C inhibits human glioma cells growth through the suppression of mTOR pathway.11
272615732016miR-1301 promotes prostate cancer proliferation through directly targeting PPP2R2C.7
226649262012PPP2R2C as a candidate gene of a temperament and character trait-based endophenotype of ADHD.3

Citation

Dessen P

PPP2R2C (protein phosphatase 2 regulatory subunit Bgamma)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46657/ppp2r2c