Identity
HGNC
LOCATION
4q24
LOCUSID
ALIAS
ACCIID,CALN,CALNA,CALNA1,CCN1,CNA1,DEE91,IECEE,IECEE1,PPP2B
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5530
MIM: 114105
HGNC: 9314
Ensembl: ENSG00000138814
Variants:
dbSNP: 5530
ClinVar: 5530
TCGA: ENSG00000138814
COSMIC: PPP3CA
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA165817016 | Kidney Transplantation | Disease | VariantAnnotation | not associated | PD | ||
| PA248 | NFKB1 | Gene | Pathway | associated | 23922006 | ||
| PA296 | RELA | Gene | Pathway | associated | 23922006 | ||
| PA31582 | NFATC1 | Gene | Pathway | associated | 23922006 | ||
| PA31583 | NFATC2 | Gene | Pathway | associated | 23922006 | ||
| PA31584 | NFATC4 | Gene | Pathway | associated | 23922006 | ||
| PA31600 | NFKB2 | Gene | Pathway | associated | 23922006 | ||
| PA34321 | REL | Gene | Pathway | associated | 23922006 | ||
| PA34322 | RELB | Gene | Pathway | associated | 23922006 | ||
| PA451578 | tacrolimus | Chemical | VariantAnnotation | not associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36525928 | 2023 | Dephosphorylation of the EGFR protein by calcineurin at serine 1046/1047 enhances its stability. | 3 |
| 36525928 | 2023 | Dephosphorylation of the EGFR protein by calcineurin at serine 1046/1047 enhances its stability. | 3 |
| 35324524 | 2022 | TRIM72 exerts antitumor effects in breast cancer and modulates lactate production and MCT4 promoter activity by interacting with PPP3CA. | 6 |
| 35324524 | 2022 | TRIM72 exerts antitumor effects in breast cancer and modulates lactate production and MCT4 promoter activity by interacting with PPP3CA. | 6 |
| 33963760 | 2021 | PPP3CA truncating variants clustered in the regulatory domain cause early-onset refractory epilepsy. | 7 |
| 34711683 | 2021 | Calcineurin regulates the stability and activity of estrogen receptor α. | 11 |
| 34795676 | 2021 | Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter? | 2 |
| 33963760 | 2021 | PPP3CA truncating variants clustered in the regulatory domain cause early-onset refractory epilepsy. | 7 |
| 34711683 | 2021 | Calcineurin regulates the stability and activity of estrogen receptor α. | 11 |
| 34795676 | 2021 | Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter? | 2 |
| 32422433 | 2020 | Regulation of the Ca(2+)-activated chloride channel Anoctamin-1 (TMEM16A) by Ca(2+)-induced interaction with FKBP12 and calcineurin. | 2 |
| 32859215 | 2020 | Calcineurin. | 62 |
| 32422433 | 2020 | Regulation of the Ca(2+)-activated chloride channel Anoctamin-1 (TMEM16A) by Ca(2+)-induced interaction with FKBP12 and calcineurin. | 2 |
| 32859215 | 2020 | Calcineurin. | 62 |
| 30254215 | 2019 | Novel calcineurin A (PPP3CA) variant associated with epilepsy, constitutive enzyme activation and downregulation of protein expression. | 20 |
Citation
Dessen P
PPP3CA (protein phosphatase 3 catalytic subunit alpha)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/41822/ppp3ca
