PPP3CB (protein phosphatase 3 catalytic subunit beta)

2003-11-01 Affiliation

Identity

HGNC

PPP3CB

LOCATION

10q22.2

LOCUSID

5532

ALIAS

CALNA2,CALNB,CNA2,PP2Bbeta

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5532
MIM: 114106
HGNC: 9315
Ensembl: ENSG00000107758

Variants:

dbSNP: 5532
ClinVar: 5532
TCGA: ENSG00000107758
COSMIC: PPP3CB

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000107758	ENST00000342558	Q5F2F8
ENSG00000107758	ENST00000360663	P16298
ENSG00000107758	ENST00000394828	P16298
ENSG00000107758	ENST00000394829	P16298
ENSG00000107758	ENST00000430762	Q5F2G0

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Calcium signaling pathway	KEGG	ko04020
Wnt signaling pathway	KEGG	ko04310
Axon guidance	KEGG	ko04360
VEGF signaling pathway	KEGG	ko04370
Natural killer cell mediated cytotoxicity	KEGG	ko04650
T cell receptor signaling pathway	KEGG	ko04660
B cell receptor signaling pathway	KEGG	ko04662
Long-term potentiation	KEGG	ko04720
Alzheimer's disease	KEGG	ko05010
Amyotrophic lateral sclerosis (ALS)	KEGG	ko05014
MAPK signaling pathway	KEGG	hsa04010
Calcium signaling pathway	KEGG	hsa04020
Wnt signaling pathway	KEGG	hsa04310
Axon guidance	KEGG	hsa04360
VEGF signaling pathway	KEGG	hsa04370
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
T cell receptor signaling pathway	KEGG	hsa04660
B cell receptor signaling pathway	KEGG	hsa04662
Long-term potentiation	KEGG	hsa04720
Alzheimer's disease	KEGG	hsa05010
Amyotrophic lateral sclerosis (ALS)	KEGG	hsa05014
Oocyte meiosis	KEGG	ko04114
Oocyte meiosis	KEGG	hsa04114
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Dopaminergic synapse	KEGG	ko04728
Dopaminergic synapse	KEGG	hsa04728
Amphetamine addiction	KEGG	hsa05031
Amphetamine addiction	KEGG	ko05031
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
Glucagon signaling pathway	KEGG	hsa04922
Glucagon signaling pathway	KEGG	ko04922
Renin secretion	KEGG	hsa04924
Renin secretion	KEGG	ko04924
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated Ca+2 mobilization	REACTOME	R-HSA-2871809
C-type lectin receptors (CLRs)	REACTOME	R-HSA-5621481
CLEC7A (Dectin-1) signaling	REACTOME	R-HSA-5607764
CLEC7A (Dectin-1) induces NFAT activation	REACTOME	R-HSA-5607763
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
Opioid Signalling	REACTOME	R-HSA-111885
DARPP-32 events	REACTOME	R-HSA-180024
Signaling by Wnt	REACTOME	R-HSA-195721
Beta-catenin independent WNT signaling	REACTOME	R-HSA-3858494
Ca2+ pathway	REACTOME	R-HSA-4086398
Th1 and Th2 cell differentiation	KEGG	ko04658
Th1 and Th2 cell differentiation	KEGG	hsa04658
Th17 cell differentiation	KEGG	ko04659
Th17 cell differentiation	KEGG	hsa04659

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA248	NFKB1	Gene	Pathway	associated	23922006
PA296	RELA	Gene	Pathway	associated	23922006
PA31582	NFATC1	Gene	Pathway	associated	23922006
PA31583	NFATC2	Gene	Pathway	associated	23922006
PA31584	NFATC4	Gene	Pathway	associated	23922006
PA31600	NFKB2	Gene	Pathway	associated	23922006
PA34321	REL	Gene	Pathway	associated	23922006
PA34322	RELB	Gene	Pathway	associated	23922006

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19136967	2009	Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point.	53
20700529	2010	Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs.	28
19659461	2009	Calcineurin dephosphorylates glycogen synthase kinase-3 beta at serine-9 in neuroblast-derived cells.	24
20379146	2010	Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity.	22
16024800	2005	Regulation of calcineurin through transcriptional induction of the calcineurin A beta promoter in vitro and in vivo.	16
21664352	2011	P43-dependent mitochondrial activity regulates myoblast differentiation and slow myosin isoform expression by control of Calcineurin expression.	15
15557343	2005	Calcineurin inhibits Na+/Ca2+ exchange in phenylephrine-treated hypertrophic cardiomyocytes.	12
21047202	2010	Using genetic and clinical factors to predict tacrolimus dose in renal transplant recipients.	12
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11

Citation

Dessen P

PPP3CB (protein phosphatase 3 catalytic subunit beta)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41823/ppp3cb