Identity
HGNC
LOCATION
2p14
LOCUSID
ALIAS
CALNB1,CNB,CNB1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5534
MIM: 601302
HGNC: 9317
Ensembl: ENSG00000221823
Variants:
dbSNP: 5534
ClinVar: 5534
TCGA: ENSG00000221823
COSMIC: PPP3R1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000221823 | ENST00000234310 | P63098 |
| ENSG00000221823 | ENST00000409377 | F6U1T9 |
| ENSG00000221823 | ENST00000409752 | D3YTA9 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA248 | NFKB1 | Gene | Pathway | associated | 23922006 | ||
| PA296 | RELA | Gene | Pathway | associated | 23922006 | ||
| PA31582 | NFATC1 | Gene | Pathway | associated | 23922006 | ||
| PA31583 | NFATC2 | Gene | Pathway | associated | 23922006 | ||
| PA31584 | NFATC4 | Gene | Pathway | associated | 23922006 | ||
| PA31600 | NFKB2 | Gene | Pathway | associated | 23922006 | ||
| PA34321 | REL | Gene | Pathway | associated | 23922006 | ||
| PA34322 | RELB | Gene | Pathway | associated | 23922006 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36901851 | 2023 | PPP3R1 Promotes MSCs Senescence by Inducing Plasma Membrane Depolarization and Increasing Ca(2+) Influx. | 0 |
| 36901851 | 2023 | PPP3R1 Promotes MSCs Senescence by Inducing Plasma Membrane Depolarization and Increasing Ca(2+) Influx. | 0 |
| 32337552 | 2020 | A rare genomic duplication in 2p14 underlies autosomal dominant hearing loss DFNA58. | 7 |
| 32882262 | 2020 | The CnB1 p.D102A variant is linked to dilated cardiomyopathy via impaired Calcineurin activity. | 0 |
| 32337552 | 2020 | A rare genomic duplication in 2p14 underlies autosomal dominant hearing loss DFNA58. | 7 |
| 32882262 | 2020 | The CnB1 p.D102A variant is linked to dilated cardiomyopathy via impaired Calcineurin activity. | 0 |
| 29181737 | 2018 | MiR-548a-3p Promotes Keratinocyte Proliferation Targeting PPP3R1 after Being Induced by IL-22. | 9 |
| 29505169 | 2018 | Effects of let-7e on LPS-Stimulated THP-1 Cells Assessed by iTRAQ Proteomic Analysis. | 1 |
| 29181737 | 2018 | MiR-548a-3p Promotes Keratinocyte Proliferation Targeting PPP3R1 after Being Induced by IL-22. | 9 |
| 29505169 | 2018 | Effects of let-7e on LPS-Stimulated THP-1 Cells Assessed by iTRAQ Proteomic Analysis. | 1 |
| 28827117 | 2017 | Association of CnB 5I/5D promoter gene polymorphism and serum calcineurin levels in early onset of coronary artery disease of south Indian cohort. | 1 |
| 28827117 | 2017 | Association of CnB 5I/5D promoter gene polymorphism and serum calcineurin levels in early onset of coronary artery disease of south Indian cohort. | 1 |
| 26471241 | 2016 | Calcineurin B stimulates cytokine production through a CD14-independent Toll-like receptor 4 pathway. | 3 |
| 27090571 | 2016 | Cellular uptake of exogenous calcineurin B is dependent on TLR4/MD2/CD14 complexes, and CnB is an endogenous ligand of TLR4. | 6 |
| 27907007 | 2016 | Exploring Regulatory Mechanisms of Atrial Myocyte Hypertrophy of Mitral Regurgitation through Gene Expression Profiling Analysis: Role of NFAT in Cardiac Hypertrophy. | 3 |
Citation
Dessen P
PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha)
Atlas Genet Cytogenet Oncol Haematol. 2007-03-01
Online version: http://atlasgeneticsoncology.org/gene/46614/ppp3r1
