PRF1 (perforin 1 (pore forming protein))

Identity

Other names	FLH2
	HPLH2
	MGC65093
	P1
	PFN1
	PFP
HGNC	PRF1
Location	10q22
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	PRF1   9360
Entrez_Gene	PRF1  5551  perforin 1 (pore forming protein)
	Cards
GeneCards	PRF1
Ensembl	PRF1 [Search_View]   ENSG00000180644 [Gene_View]
Genatlas	PRF1
GeneLynx	PRF1
eGenome	PRF1
euGene	5551
	Genomic and cartography
GoldenPath	PRF1  -  10q22   chr10:72027110-72032537 -  10q22.1   [Description]    (hg18-March_2006)
Ensembl	PRF1 - 10q22.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	PRF1
	Gene and transcription
Genbank	AB209604 [ ENTREZ ]
Genbank	AK312754 [ ENTREZ ]
Genbank	BC047695 [ ENTREZ ]
Genbank	BC063043 [ ENTREZ ]
Genbank	BQ051559 [ ENTREZ ]
RefSeq	NM_001083116 [ SRS ]    NM_001083116 [ ENTREZ ]
RefSeq	NM_005041 [ SRS ]    NM_005041 [ ENTREZ ]
RefSeq	AC_000053 [ SRS ]    AC_000053 [ ENTREZ ]
RefSeq	AC_000142 [ SRS ]    AC_000142 [ ENTREZ ]
RefSeq	NC_000010 [ SRS ]    NC_000010 [ ENTREZ ]
RefSeq	NT_008583 [ SRS ]    NT_008583 [ ENTREZ ]
RefSeq	NW_001837986 [ SRS ]    NW_001837986 [ ENTREZ ]
RefSeq	NW_924796 [ SRS ]    NW_924796 [ ENTREZ ]
AceView	PRF1 AceView - NCBI
Unigene	Hs.2200 [ SRS ]    Hs.2200 [ NCBI ]     HS2200 [ spliceNest ]
Fast-db	13029 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P14222 [ SRS]    P14222 [ EXPASY ]     P14222 [ INTERPRO ]     P14222 [ UNIPROT ]
Prosite	PS50004 C2 [ SRS ]    PS50004 C2 [ Expasy ]
Prosite	PS00022 EGF_1 [ SRS ]    PS00022 EGF_1 [ Expasy ]
Prosite	PS01186 EGF_2 [ SRS ]    PS01186 EGF_2 [ Expasy ]
Prosite	PS50026 EGF_3 [ SRS ]    PS50026 EGF_3 [ Expasy ]
Prosite	PS00279 MAC_PERFORIN [ SRS ]    PS00279 MAC_PERFORIN [ Expasy ]
Interpro	IPR000008 C2_Ca-dep [ SRS ]    IPR000008 C2_Ca-dep [ EBI ]
Interpro	IPR000742 EGF_3 [ SRS ]    IPR000742 EGF_3 [ EBI ]
Interpro	IPR013032 EGF_like_reg_CS [ SRS ]    IPR013032 EGF_like_reg_CS [ EBI ]
Interpro	IPR001862 MAC_perforin [ SRS ]    IPR001862 MAC_perforin [ EBI ]
CluSTr	P14222
Pfam	PF00168 C2 [ SRS ]    PF00168 C2 [ Sanger ]    pfam00168 [ NCBI-CDD ]
Pfam	PF01823 MACPF [ SRS ]    PF01823 MACPF [ Sanger ]    pfam01823 [ NCBI-CDD ]
Smart	SM00239 C2 [EMBL]
Smart	SM00457 MACPF [EMBL]
Blocks	P14222
HPRD	01362
	Protein Interaction databases
DIP	P14222
IntAct	P14222
	Polymorphism : SNP, mutations, diseases
OMIM	170280;603553;605027    [ map ]
GENECLINICS	170280;603553;605027
SNP	PRF1 [dbSNP-NCBI]
SNP	NM_001083116 [SNP-NCI]
SNP	NM_005041 [SNP-NCI]
SNP	PRF1 [GeneSNPs - Utah]  PRF1] [HGBASE - SRS]
HAPMAP	PRF1 [HAPMAP]
HGMD	PRF1
	General knowledge
Family Browser	PRF1 [UCSC Family Browser]
SOURCE	NM_001083116
SOURCE	NM_005041
SMD	Hs.2200
SAGE	Hs.2200
GO	calcium ion binding [Amigo]  calcium ion binding
GO	apoptosis [Amigo]  apoptosis
GO	cellular defense response [Amigo]  cellular defense response
GO	circadian rhythm [Amigo]  circadian rhythm
GO	pathogenesis [Amigo]  pathogenesis
GO	membrane [Amigo]  membrane
GO	integral to membrane [Amigo]  integral to membrane
GO	cytoplasmic membrane-bounded vesicle [Amigo]  cytoplasmic membrane-bounded vesicle
GO	cytolysis [Amigo]  cytolysis
GO	response to ethanol [Amigo]  response to ethanol
BIOCARTA	Caspase Cascade in Apoptosis    [Genes]
BIOCARTA	CTL mediated immune response against target cells    [Genes]
BIOCARTA	D4-GDI Signaling Pathway    [Genes]
BIOCARTA	Granzyme A mediated Apoptosis Pathway    [Genes]
KEGG	Natural killer cell mediated cytotoxicity
KEGG	Type I diabetes mellitus
PubGene	PRF1
TreeFam	PRF1
CTD	5551 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	PRF1 Related clones (RZPD - Berlin)
	PubMed
PubMed	76 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:26:33 2008