PRKAA1 (protein kinase, AMP-activated, alpha 1 catalytic subunit)

Identity

Other names	AMPK
	AMPKa1
	MGC33776
	MGC57364
HGNC	PRKAA1
Location	5p12
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	PRKAA1   9376
Entrez_Gene	PRKAA1  5562  protein kinase, AMP-activated, alpha 1 catalytic subunit
	Cards
GeneCards	PRKAA1
Ensembl	PRKAA1 [Search_View]   ENSG00000132356 [Gene_View]
Genatlas	PRKAA1
GeneLynx	PRKAA1
eGenome	PRKAA1
euGene	5562
	Genomic and cartography
GoldenPath	PRKAA1  -  5p12   chr5:40795238-40834054 -  5p13.1   [Description]    (hg18-March_2006)
Ensembl	PRKAA1 - 5p13.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	PRKAA1
	Gene and transcription
Genbank	AB022017 [ ENTREZ ]
Genbank	AF100763 [ ENTREZ ]
Genbank	AK024252 [ ENTREZ ]
Genbank	AK307546 [ ENTREZ ]
Genbank	AK312947 [ ENTREZ ]
RefSeq	NM_006251 [ SRS ]    NM_006251 [ ENTREZ ]
RefSeq	NM_206907 [ SRS ]    NM_206907 [ ENTREZ ]
RefSeq	AC_000048 [ SRS ]    AC_000048 [ ENTREZ ]
RefSeq	AC_000137 [ SRS ]    AC_000137 [ ENTREZ ]
RefSeq	NC_000005 [ SRS ]    NC_000005 [ ENTREZ ]
RefSeq	NT_006576 [ SRS ]    NT_006576 [ ENTREZ ]
RefSeq	NW_001838933 [ SRS ]    NW_001838933 [ ENTREZ ]
RefSeq	NW_922596 [ SRS ]    NW_922596 [ ENTREZ ]
AceView	PRKAA1 AceView - NCBI
Unigene	Hs.43322 [ SRS ]    Hs.43322 [ NCBI ]     HS43322 [ spliceNest ]
Fast-db	3198 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q13131 [ SRS]    Q13131 [ EXPASY ]     Q13131 [ INTERPRO ]     Q13131 [ UNIPROT ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Interpro	IPR015741 AMPK [ SRS ]    IPR015741 AMPK [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
Interpro	IPR002290 Ser_thr_pkinase [ SRS ]    IPR002290 Ser_thr_pkinase [ EBI ]
CluSTr	Q13131
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Smart	SM00220 S_TKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	Q13131 AAPK1_HUMAN [ Domain structure ]   Q13131 AAPK1_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	Q13131
HPRD	04115
	Protein Interaction databases
DIP	Q13131
IntAct	Q13131
	Polymorphism : SNP, mutations, diseases
OMIM	602739    [ map ]
GENECLINICS	602739
SNP	PRKAA1 [dbSNP-NCBI]
SNP	NM_006251 [SNP-NCI]
SNP	NM_206907 [SNP-NCI]
SNP	PRKAA1 [GeneSNPs - Utah]  PRKAA1] [HGBASE - SRS]
HAPMAP	PRKAA1 [HAPMAP]
COSMIC	PRKAA1 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	PRKAA1
	General knowledge
Family Browser	PRKAA1 [UCSC Family Browser]
SOURCE	NM_006251
SOURCE	NM_206907
SMD	Hs.43322
SAGE	Hs.43322
GO	nucleotide binding [Amigo]  nucleotide binding
GO	activation of MAPK activity [Amigo]  activation of MAPK activity
GO	magnesium ion binding [Amigo]  magnesium ion binding
GO	response to hypoxia [Amigo]  response to hypoxia
GO	protein serine/threonine kinase activity [Amigo]  protein serine/threonine kinase activity
GO	cAMP-dependent protein kinase activity [Amigo]  cAMP-dependent protein kinase activity
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	intracellular [Amigo]  intracellular
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	fatty acid biosynthetic process [Amigo]  fatty acid biosynthetic process
GO	signal transduction [Amigo]  signal transduction
GO	transferase activity [Amigo]  transferase activity
GO	positive regulation of cholesterol biosynthetic process [Amigo]  positive regulation of cholesterol biosynthetic process
GO	positive regulation of anti-apoptosis [Amigo]  positive regulation of anti-apoptosis
GO	negative regulation of glucosylceramide biosynthetic process [Amigo]  negative regulation of glucosylceramide biosynthetic process
BIOCARTA	ChREBP regulation by carbohydrates and cAMP    [Genes]
BIOCARTA	Reversal of Insulin Resistance by Leptin    [Genes]
KEGG	Regulation of autophagy
KEGG	mTOR signaling pathway
KEGG	Insulin signaling pathway
KEGG	Adipocytokine signaling pathway
PubGene	PRKAA1
TreeFam	PRKAA1
CTD	5562 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	PRKAA1 Related clones (RZPD - Berlin)
	PubMed
PubMed	52 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:26:37 2008