Identity
HGNC
LOCATION
17q24.2
LOCUSID
ALIAS
AAG6,PKC-alpha,PKCA,PKCI+/-,PKCalpha,PRKACA
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5578
MIM: 176960
HGNC: 9393
Ensembl: ENSG00000154229
Variants:
dbSNP: 5578
ClinVar: 5578
TCGA: ENSG00000154229
COSMIC: PRKCA
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000154229 | ENST00000284384 | J3KN97 |
| ENSG00000154229 | ENST00000413366 | P17252 |
| ENSG00000154229 | ENST00000413366 | L7RSM7 |
| ENSG00000154229 | ENST00000578063 | J3KRN5 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128394595 | PLCH1 | Gene | Pathway | associated | |||
| PA130232992 | bevacizumab | Chemical | ClinicalAnnotation | associated | PD | 29871907 | |
| PA134875646 | PLCZ1 | Gene | Pathway | associated | |||
| PA134914471 | PLCH2 | Gene | Pathway | associated | |||
| PA248 | NFKB1 | Gene | Pathway | associated | |||
| PA27749 | ELK1 | Gene | Pathway | associated | |||
| PA28212 | FOS | Gene | Pathway | associated | |||
| PA296 | RELA | Gene | Pathway | associated | |||
| PA30006 | JUN | Gene | Pathway | associated | |||
| PA31353 | MYC | Gene | Pathway | associated | |||
| PA31600 | NFKB2 | Gene | Pathway | associated | |||
| PA33384 | PLCB1 | Gene | Pathway | associated | |||
| PA33385 | PLCB2 | Gene | Pathway | associated | |||
| PA33386 | PLCB3 | Gene | Pathway | associated | |||
| PA33387 | PLCB4 | Gene | Pathway | associated | |||
| PA33388 | PLCD1 | Gene | Pathway | associated | |||
| PA33389 | PLCD3 | Gene | Pathway | associated | |||
| PA33390 | PLCD4 | Gene | Pathway | associated | |||
| PA33391 | PLCE1 | Gene | Pathway | associated | |||
| PA33392 | PLCG1 | Gene | Pathway | associated | 20124951 | ||
| PA33393 | PLCG2 | Gene | Pathway | associated | 20124951 | ||
| PA33394 | PLCL1 | Gene | Pathway | associated | |||
| PA33395 | PLCL2 | Gene | Pathway | associated | |||
| PA337 | STAT3 | Gene | Pathway | associated | |||
| PA338 | STAT5A | Gene | Pathway | associated | |||
| PA34183 | RAF1 | Gene | Pathway | associated | 20124951 | ||
| PA36042 | SP1 | Gene | Pathway | associated | |||
| PA36183 | STAT1 | Gene | Pathway | associated | |||
| PA36184 | STAT2 | Gene | Pathway | associated | |||
| PA36185 | STAT4 | Gene | Pathway | associated | |||
| PA36186 | STAT5B | Gene | Pathway | associated | |||
| PA39 | ADRB2 | Gene | Pathway | associated | |||
| PA444552 | Hypertension | Disease | ClinicalAnnotation | associated | PD | 29871907 | |
| PA449899 | hydrochlorothiazide | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38164042 | 2024 | Cav-1 regulates the bile salt export pump on the canalicular membrane of hepatocytes by PKCα-associated signalling under cholesterol stimulation. | 1 |
| 38815861 | 2024 | Multi-modal mechanisms of the metastasis suppressor, NDRG1: Inhibition of WNT/β-catenin signaling by stabilization of protein kinase Cα. | 0 |
| 38164042 | 2024 | Cav-1 regulates the bile salt export pump on the canalicular membrane of hepatocytes by PKCα-associated signalling under cholesterol stimulation. | 1 |
| 38815861 | 2024 | Multi-modal mechanisms of the metastasis suppressor, NDRG1: Inhibition of WNT/β-catenin signaling by stabilization of protein kinase Cα. | 0 |
| 36478369 | 2023 | PKCα interacts with Ca(v) 1.3 calcium channels to promote the Ca(v) 1.2/Ca(v) 1.3 duo tuning Th2 functions. | 0 |
| 36648303 | 2023 | Protein Kinase C Modulation Determines the Mesoderm/Extraembryonic Fate Under BMP4 Induction From Human Pluripotent Stem Cells. | 1 |
| 36791912 | 2023 | Crosstalk between protein kinase C α and transforming growth factor β signaling mediated by Runx2 in intestinal epithelial cells. | 1 |
| 36979484 | 2023 | Spatiotemporal Regulation of FMNL2 by N-Terminal Myristoylation and C-Terminal Phosphorylation Drives Rapid Filopodia Formation. | 2 |
| 37463241 | 2023 | Histone Methyltransferase NSD2 Activates PKCα to Drive Metabolic Reprogramming and Lenalidomide Resistance in Multiple Myeloma. | 0 |
| 36478369 | 2023 | PKCα interacts with Ca(v) 1.3 calcium channels to promote the Ca(v) 1.2/Ca(v) 1.3 duo tuning Th2 functions. | 0 |
| 36648303 | 2023 | Protein Kinase C Modulation Determines the Mesoderm/Extraembryonic Fate Under BMP4 Induction From Human Pluripotent Stem Cells. | 1 |
| 36791912 | 2023 | Crosstalk between protein kinase C α and transforming growth factor β signaling mediated by Runx2 in intestinal epithelial cells. | 1 |
| 36979484 | 2023 | Spatiotemporal Regulation of FMNL2 by N-Terminal Myristoylation and C-Terminal Phosphorylation Drives Rapid Filopodia Formation. | 2 |
| 37463241 | 2023 | Histone Methyltransferase NSD2 Activates PKCα to Drive Metabolic Reprogramming and Lenalidomide Resistance in Multiple Myeloma. | 0 |
| 34825477 | 2022 | Gene-gene interactions in the protein kinase C/endothelial nitric oxide synthase axis impact the hypotensive effects of propofol. | 1 |
Citation
Dessen P
PRKCA (protein kinase C alpha)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/41851/prkca
