PRMT5 (protein arginine methyltransferase 5)

Identity

Other names	HRMT1L5
	IBP72
	JBP1
	SKB1
	SKB1Hs
HGNC	PRMT5
Location	14q11.2
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	PRMT5   10894
Entrez_Gene	PRMT5  10419  protein arginine methyltransferase 5
	Cards
GeneCards	PRMT5
Ensembl	PRMT5 [Search_View]   ENSG00000100462 [Gene_View]
Genatlas	PRMT5
GeneLynx	PRMT5
eGenome	PRMT5
euGene	10419
	Genomic and cartography
GoldenPath	PRMT5  -  14q11.2   chr14:22459573-22468501 -  14q11.2   [Description]    (hg18-March_2006)
Ensembl	PRMT5 - 14q11.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	PRMT5
	Gene and transcription
Genbank	AF015913 [ ENTREZ ]
Genbank	AF167572 [ ENTREZ ]
Genbank	AK027737 [ ENTREZ ]
Genbank	AK075251 [ ENTREZ ]
Genbank	AK315500 [ ENTREZ ]
RefSeq	NM_001039619 [ SRS ]    NM_001039619 [ ENTREZ ]
RefSeq	NM_006109 [ SRS ]    NM_006109 [ ENTREZ ]
RefSeq	AC_000057 [ SRS ]    AC_000057 [ ENTREZ ]
RefSeq	AC_000146 [ SRS ]    AC_000146 [ ENTREZ ]
RefSeq	NC_000014 [ SRS ]    NC_000014 [ ENTREZ ]
RefSeq	NT_026437 [ SRS ]    NT_026437 [ ENTREZ ]
RefSeq	NW_001838110 [ SRS ]    NW_001838110 [ ENTREZ ]
RefSeq	NW_925539 [ SRS ]    NW_925539 [ ENTREZ ]
AceView	PRMT5 AceView - NCBI
Unigene	Hs.367854 [ SRS ]    Hs.367854 [ NCBI ]     HS367854 [ spliceNest ]
Fast-db	61 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O14744 [ SRS]    O14744 [ EXPASY ]     O14744 [ INTERPRO ]     O14744 [ UNIPROT ]
Interpro	IPR007857 Skb1_MeTrfase [ SRS ]    IPR007857 Skb1_MeTrfase [ EBI ]
CluSTr	O14744
Pfam	PF05185 PRMT5 [ SRS ]    PF05185 PRMT5 [ Sanger ]    pfam05185 [ NCBI-CDD ]
Blocks	O14744
HPRD	04955
	Protein Interaction databases
DIP	O14744
IntAct	O14744
	Polymorphism : SNP, mutations, diseases
OMIM	604045    [ map ]
GENECLINICS	604045
SNP	PRMT5 [dbSNP-NCBI]
SNP	NM_001039619 [SNP-NCI]
SNP	NM_006109 [SNP-NCI]
SNP	PRMT5 [GeneSNPs - Utah]  PRMT5] [HGBASE - SRS]
HAPMAP	PRMT5 [HAPMAP]
HGMD	PRMT5
	General knowledge
Family Browser	PRMT5 [UCSC Family Browser]
SOURCE	NM_001039619
SOURCE	NM_006109
SMD	Hs.367854
SAGE	Hs.367854
Enzyme	2.1.1.125 [ Enzyme-Expasy ]   2.1.1.125 [ Enzyme-SRS ]   2.1.1.125 [ IntEnz-EBI ]   2.1.1.125 [ BRENDA ]   2.1.1.125 [ KEGG ]   2.1.1.125 [ WIT ]
GO	spliceosomal snRNP biogenesis [Amigo]  spliceosomal snRNP biogenesis
GO	cytoplasm [Amigo]  cytoplasm
GO	transcription [Amigo]  transcription
GO	regulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
GO	regulation of mitosis [Amigo]  regulation of mitosis
GO	methyltransferase activity [Amigo]  methyltransferase activity
GO	methyltransferase activity [Amigo]  methyltransferase activity
GO	cell proliferation [Amigo]  cell proliferation
GO	histone-arginine N-methyltransferase activity [Amigo]  histone-arginine N-methyltransferase activity
GO	chromatin modification [Amigo]  chromatin modification
GO	transferase activity [Amigo]  transferase activity
GO	peptidyl-arginine N-methylation [Amigo]  peptidyl-arginine N-methylation
KEGG	Androgen and estrogen metabolism
KEGG	Histidine metabolism
KEGG	Tyrosine metabolism
KEGG	Tryptophan metabolism
KEGG	Aminophosphonate metabolism
KEGG	Selenoamino acid metabolism
KEGG	Nitrobenzene degradation
PubGene	PRMT5
TreeFam	PRMT5
CTD	10419 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	PRMT5 Related clones (RZPD - Berlin)
	PubMed
PubMed	33 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:26:50 2008