PRNP (prion protein)

Identity

Other names	ASCR
	CD230
	CJD
	GSS
	MGC26679
	PRIP
	PrP
	PrP27-30
	PrP33-35C
	PrPc
	prion
HGNC	PRNP
Location	20p13
Location_base_pair	Starts at 4614797 and ends at 4630234 bp from pter (hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	PRNP   9449
Entrez_Gene	PRNP  5621  prion protein
	Cards
GeneCards	PRNP
Ensembl	PRNP [Search_View]   ENSG00000171867 [Gene_View]
Genatlas	PRNP
GeneLynx	PRNP
eGenome	PRNP
euGene	5621
	Genomic and cartography
GoldenPath	PRNP  -  20p13   chr20:4614797-4630234 +  20p13   [Description]    (hg18-March_2006)
Ensembl	PRNP - 20p13 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	PRNP
	Gene and transcription
Genbank	AB300823 [ ENTREZ ]
Genbank	AB300825 [ ENTREZ ]
Genbank	AK090575 [ ENTREZ ]
Genbank	AW452130 [ ENTREZ ]
Genbank	AY008282 [ ENTREZ ]
RefSeq	NM_000311 [ SRS ]    NM_000311 [ ENTREZ ]
RefSeq	NM_001080121 [ SRS ]    NM_001080121 [ ENTREZ ]
RefSeq	NM_001080122 [ SRS ]    NM_001080122 [ ENTREZ ]
RefSeq	NM_001080123 [ SRS ]    NM_001080123 [ ENTREZ ]
RefSeq	NM_183079 [ SRS ]    NM_183079 [ ENTREZ ]
RefSeq	AC_000063 [ SRS ]    AC_000063 [ ENTREZ ]
RefSeq	AC_000152 [ SRS ]    AC_000152 [ ENTREZ ]
RefSeq	NC_000020 [ SRS ]    NC_000020 [ ENTREZ ]
RefSeq	NT_011387 [ SRS ]    NT_011387 [ ENTREZ ]
RefSeq	NW_001838652 [ SRS ]    NW_001838652 [ ENTREZ ]
RefSeq	NW_927317 [ SRS ]    NW_927317 [ ENTREZ ]
AceView	PRNP AceView - NCBI
Unigene	Hs.714553 [ SRS ]    Hs.714553 [ NCBI ]     HS714553 [ spliceNest ]
Fast-db	4417 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O75942 [ SRS]    O75942 [ EXPASY ]     O75942 [ INTERPRO ]     O75942 [ UNIPROT ]
Prosite	PS00291 PRION_1 [ SRS ]    PS00291 PRION_1 [ Expasy ]
Prosite	PS00706 PRION_2 [ SRS ]    PS00706 PRION_2 [ Expasy ]
Interpro	IPR013286 AnnexinVII [ SRS ]    IPR013286 AnnexinVII [ EBI ]
Interpro	IPR000817 Prion [ SRS ]    IPR000817 Prion [ EBI ]
CluSTr	O75942
Pfam	PF00377 Prion [ SRS ]    PF00377 Prion [ Sanger ]    pfam00377 [ NCBI-CDD ]
Pfam	PF03991 Prion_octapep [ SRS ]    PF03991 Prion_octapep [ Sanger ]    pfam03991 [ NCBI-CDD ]
Smart	SM00157 PRP [EMBL]
Blocks	O75942
HPRD	01453
	Protein Interaction databases
DIP	O75942
IntAct	O75942
	Polymorphism : SNP, mutations, diseases
OMIM	123400;137440;176640;600072;603218;606688    [ map ]
GENECLINICS	123400;137440;176640;600072;603218;606688
SNP	PRNP [dbSNP-NCBI]
SNP	NM_000311 [SNP-NCI]
SNP	NM_001080121 [SNP-NCI]
SNP	NM_001080122 [SNP-NCI]
SNP	NM_001080123 [SNP-NCI]
SNP	NM_183079 [SNP-NCI]
SNP	PRNP [GeneSNPs - Utah]  PRNP] [HGBASE - SRS]
HAPMAP	PRNP [HAPMAP]
HGMD	PRNP
	General knowledge
Family Browser	PRNP [UCSC Family Browser]
SOURCE	NM_000311
SOURCE	NM_001080121
SOURCE	NM_001080122
SOURCE	NM_001080123
SOURCE	NM_183079
SMD	Hs.714553
SAGE	Hs.714553
GO	copper ion binding [Amigo]  copper ion binding
GO	cytoplasm [Amigo]  cytoplasm
GO	endoplasmic reticulum [Amigo]  endoplasmic reticulum
GO	Golgi apparatus [Amigo]  Golgi apparatus
GO	plasma membrane [Amigo]  plasma membrane
GO	cellular copper ion homeostasis [Amigo]  cellular copper ion homeostasis
GO	anti-apoptosis [Amigo]  anti-apoptosis
GO	response to oxidative stress [Amigo]  response to oxidative stress
GO	microtubule binding [Amigo]  microtubule binding
GO	metabolic process [Amigo]  metabolic process
GO	membrane [Amigo]  membrane
GO	extrinsic to membrane [Amigo]  extrinsic to membrane
GO	anchored to membrane [Amigo]  anchored to membrane
GO	identical protein binding [Amigo]  identical protein binding
GO	membrane raft [Amigo]  membrane raft
GO	response to cadmium ion [Amigo]  response to cadmium ion
GO	response to copper ion [Amigo]  response to copper ion
GO	protein homooligomerization [Amigo]  protein homooligomerization
BIOCARTA	Prion Pathway    [Genes]
KEGG	Neurodegenerative Disorders
KEGG	Prion disease
PubGene	PRNP
TreeFam	PRNP
CTD	5621 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	PRNP Related clones (RZPD - Berlin)
	PubMed
PubMed	291 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 11 13:27:37 2008