PTPN6 (protein tyrosine phosphatase, non-receptor type 6)

Identity

Other names	HCP
	HCPH
	HPTP1C
	PTP-1C
	SH-PTP1
	SHP-1
	SHP-1L
	SHP1
HGNC	PTPN6
Location	12p13.31
Location_base_pair	Starts at 6930695 and ends at 6940740 bp from pter (hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	PTPN6   9658
Entrez_Gene	PTPN6  5777  protein tyrosine phosphatase, non-receptor type 6
	Cards
GeneCards	PTPN6
Ensembl	PTPN6 [Search_View]   ENSG00000111679 [Gene_View]
Genatlas	PTPN6
GeneLynx	PTPN6
eGenome	PTPN6
euGene	5777
	Genomic and cartography
GoldenPath	PTPN6  -  12p13.31   chr12:6930695-6940740 +  12p13.31   [Description]    (hg18-March_2006)
Ensembl	PTPN6 - 12p13.31 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	PTPN6
	Gene and transcription
Genbank	AF178946 [ ENTREZ ]
Genbank	AK223629 [ ENTREZ ]
Genbank	AK290421 [ ENTREZ ]
Genbank	AK298470 [ ENTREZ ]
Genbank	AK300167 [ ENTREZ ]
RefSeq	NM_002831 [ SRS ]    NM_002831 [ ENTREZ ]
RefSeq	NM_080548 [ SRS ]    NM_080548 [ ENTREZ ]
RefSeq	NM_080549 [ SRS ]    NM_080549 [ ENTREZ ]
RefSeq	AC_000055 [ SRS ]    AC_000055 [ ENTREZ ]
RefSeq	AC_000144 [ SRS ]    AC_000144 [ ENTREZ ]
RefSeq	NC_000012 [ SRS ]    NC_000012 [ ENTREZ ]
RefSeq	NT_009759 [ SRS ]    NT_009759 [ ENTREZ ]
RefSeq	NW_001838050 [ SRS ]    NW_001838050 [ ENTREZ ]
RefSeq	NW_925295 [ SRS ]    NW_925295 [ ENTREZ ]
AceView	PTPN6 AceView - NCBI
Unigene	Hs.63489 [ SRS ]    Hs.63489 [ NCBI ]     HS63489 [ spliceNest ]
Fast-db	1539 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P29350 [ SRS]    P29350 [ EXPASY ]     P29350 [ INTERPRO ]     P29350 [ UNIPROT ]
Prosite	PS50001 SH2 [ SRS ]    PS50001 SH2 [ Expasy ]
Prosite	PS00383 TYR_PHOSPHATASE_1 [ SRS ]    PS00383 TYR_PHOSPHATASE_1 [ Expasy ]
Prosite	PS50056 TYR_PHOSPHATASE_2 [ SRS ]    PS50056 TYR_PHOSPHATASE_2 [ Expasy ]
Prosite	PS50055 TYR_PHOSPHATASE_PTP [ SRS ]    PS50055 TYR_PHOSPHATASE_PTP [ Expasy ]
Interpro	IPR000980 SH2 [ SRS ]    IPR000980 SH2 [ EBI ]
Interpro	IPR000387 Tyr_Pase [ SRS ]    IPR000387 Tyr_Pase [ EBI ]
Interpro	IPR016130 Tyr_Pase_AS [ SRS ]    IPR016130 Tyr_Pase_AS [ EBI ]
Interpro	IPR012152 Tyr_Pase_non-rcpt_typ-6/11 [ SRS ]    IPR012152 Tyr_Pase_non-rcpt_typ-6/11 [ EBI ]
Interpro	IPR000242 Tyr_Pase_rcpt/non-rcpt [ SRS ]    IPR000242 Tyr_Pase_rcpt/non-rcpt [ EBI ]
CluSTr	P29350
Pfam	PF00017 SH2 [ SRS ]    PF00017 SH2 [ Sanger ]    pfam00017 [ NCBI-CDD ]
Pfam	PF00102 Y_phosphatase [ SRS ]    PF00102 Y_phosphatase [ Sanger ]    pfam00102 [ NCBI-CDD ]
Smart	SM00194 PTPc [EMBL]
Smart	SM00252 SH2 [EMBL]
Prodom	PD000093 SH2[INRA-Toulouse]
Prodom	P29350 PTN6_HUMAN [ Domain structure ]   P29350 PTN6_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P29350
PDB	1FPR [ SRS ]    1FPR [ PdbSum ],   1FPR [ IMB ]   1FPR [ RSDB ]
PDB	1GWZ [ SRS ]    1GWZ [ PdbSum ],   1GWZ [ IMB ]   1GWZ [ RSDB ]
PDB	1X6C [ SRS ]    1X6C [ PdbSum ],   1X6C [ IMB ]   1X6C [ RSDB ]
PDB	2B3O [ SRS ]    2B3O [ PdbSum ],   2B3O [ IMB ]   2B3O [ RSDB ]
PDB	2YU7 [ SRS ]    2YU7 [ PdbSum ],   2YU7 [ IMB ]   2YU7 [ RSDB ]
HPRD	01475
	Protein Interaction databases
DIP	P29350
IntAct	P29350
	Polymorphism : SNP, mutations, diseases
OMIM	176883    [ map ]
GENECLINICS	176883
SNP	PTPN6 [dbSNP-NCBI]
SNP	NM_002831 [SNP-NCI]
SNP	NM_080548 [SNP-NCI]
SNP	NM_080549 [SNP-NCI]
SNP	PTPN6 [GeneSNPs - Utah]  PTPN6] [HGBASE - SRS]
HAPMAP	PTPN6 [HAPMAP]
COSMIC	PTPN6 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	PTPN6
	General knowledge
Family Browser	PTPN6 [UCSC Family Browser]
SOURCE	NM_002831
SOURCE	NM_080548
SOURCE	NM_080549
SMD	Hs.63489
SAGE	Hs.63489
Enzyme	3.1.3.48 [ Enzyme-Expasy ]   3.1.3.48 [ Enzyme-SRS ]   3.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   3.1.3.48 [ WIT ]
GO	phosphotyrosine binding [Amigo]  phosphotyrosine binding
GO	molecular_function [Amigo]  molecular_function
GO	protein tyrosine phosphatase activity [Amigo]  protein tyrosine phosphatase activity
GO	protein tyrosine phosphatase activity [Amigo]  protein tyrosine phosphatase activity
GO	protein binding [Amigo]  protein binding
GO	protein binding [Amigo]  protein binding
GO	cellular_component [Amigo]  cellular_component
GO	nucleus [Amigo]  nucleus
GO	cytoplasm [Amigo]  cytoplasm
GO	cytosol [Amigo]  cytosol
GO	protein amino acid dephosphorylation [Amigo]  protein amino acid dephosphorylation
GO	protein amino acid dephosphorylation [Amigo]  protein amino acid dephosphorylation
GO	apoptosis [Amigo]  apoptosis
GO	G-protein coupled receptor protein signaling pathway [Amigo]  G-protein coupled receptor protein signaling pathway
GO	intracellular signaling cascade [Amigo]  intracellular signaling cascade
GO	negative regulation of cell proliferation [Amigo]  negative regulation of cell proliferation
GO	response to wounding [Amigo]  response to wounding
GO	membrane [Amigo]  membrane
GO	hydrolase activity [Amigo]  hydrolase activity
GO	phosphatase activity [Amigo]  phosphatase activity
BIOCARTA	EPO Signaling Pathway    [Genes]
BIOCARTA	Growth Hormone Signaling Pathway    [Genes]
BIOCARTA	IL-2 Receptor Beta Chain in T cell Activation    [Genes]
BIOCARTA	IL 3 signaling pathway    [Genes]
BIOCARTA	Ras-Independent pathway in NK cell-mediated cytotoxicity    [Genes]
KEGG	Adherens junction
KEGG	Jak-STAT signaling pathway
KEGG	Natural killer cell mediated cytotoxicity
KEGG	T cell receptor signaling pathway
KEGG	B cell receptor signaling pathway
PubGene	PTPN6
TreeFam	PTPN6
CTD	5777 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	PTPN6 Related clones (RZPD - Berlin)
	PubMed
PubMed	192 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 11 13:28:12 2008