RAC1 (ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1))

Identity

Other names	MGC111543
	MIG5
	TC-25
	p21-Rac1
HGNC	RAC1
Location	7p22
Location_base_pair	Starts at 6380651 and ends at 6410123 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	RAC1   9801
Entrez_Gene	RAC1  5879  ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
	Cards
GeneCards	RAC1
Ensembl	ENSG00000136238 [Gene_View]  RAC1 [Vega]
Genatlas	RAC1
	Genomic and cartography
GoldenPath	RAC1  -  7p22   chr7:6380651-6410123 +  7p22.1   [Description]    (hg18-March_2006)
Ensembl	RAC1 - 7p22.1 [CytoView]
NCBI	Mapview
OMIM	602048 Disease map [OMIM]
HomoloGene	RAC1
	Gene and transcription
Genbank	AB209410 [ ENTREZ ]
Genbank	AF136373 [ ENTREZ ]
Genbank	AF498964 [ ENTREZ ]
Genbank	AJ132694 [ ENTREZ ]
Genbank	AK054993 [ ENTREZ ]
RefSeq	NM_006908 [ SRS ]    NM_006908 [ ENTREZ ]
RefSeq	NM_018890 [ SRS ]    NM_018890 [ ENTREZ ]
RefSeq	NM_198829 [ SRS ]    NM_198829 [ ENTREZ ]
RefSeq	AC_000050 [ SRS ]    AC_000050 [ ENTREZ ]
RefSeq	AC_000068 [ SRS ]    AC_000068 [ ENTREZ ]
RefSeq	AC_000139 [ SRS ]    AC_000139 [ ENTREZ ]
RefSeq	NC_000007 [ SRS ]    NC_000007 [ ENTREZ ]
RefSeq	NT_007819 [ SRS ]    NT_007819 [ ENTREZ ]
RefSeq	NT_079592 [ SRS ]    NT_079592 [ ENTREZ ]
RefSeq	NW_001839003 [ SRS ]    NW_001839003 [ ENTREZ ]
RefSeq	NW_923217 [ SRS ]    NW_923217 [ ENTREZ ]
CCDS	RAC1 CCDS - NCBI
AceView	RAC1 AceView - NCBI
Unigene	Hs.413812 [ SRS ]    Hs.413812 [ NCBI ]
Fast-db	1693 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P63000 [ SRS]    P63000 [ EXPASY ]     P63000 [ INTERPRO ]     P63000 [ UNIPROT ] P63000 [ VarSplice FASTA ]
Interpro	IPR003578 GTPase_Rho [ SRS ]    IPR003578 GTPase_Rho [ EBI ]
Interpro	IPR013753 Ras [ SRS ]    IPR013753 Ras [ EBI ]
Interpro	IPR001806 Ras_trnsfrmng [ SRS ]    IPR001806 Ras_trnsfrmng [ EBI ]
Interpro	IPR005225 Small_GTP_bd [ SRS ]    IPR005225 Small_GTP_bd [ EBI ]
CluSTr	P63000
Pfam	PF00071 Ras [ SRS ]    PF00071 Ras [ Sanger ]    pfam00071 [ NCBI-CDD ]
Smart	SM00174 RHO [EMBL]
Blocks	P63000
PDB	1E96 [ SRS ]    1E96 [ PdbSum ],   1E96 [ IMB ]   1E96 [ RSDB ]
PDB	1FOE [ SRS ]    1FOE [ PdbSum ],   1FOE [ IMB ]   1FOE [ RSDB ]
PDB	1G4U [ SRS ]    1G4U [ PdbSum ],   1G4U [ IMB ]   1G4U [ RSDB ]
PDB	1HE1 [ SRS ]    1HE1 [ PdbSum ],   1HE1 [ IMB ]   1HE1 [ RSDB ]
PDB	1HH4 [ SRS ]    1HH4 [ PdbSum ],   1HH4 [ IMB ]   1HH4 [ RSDB ]
PDB	1I4D [ SRS ]    1I4D [ PdbSum ],   1I4D [ IMB ]   1I4D [ RSDB ]
PDB	1I4L [ SRS ]    1I4L [ PdbSum ],   1I4L [ IMB ]   1I4L [ RSDB ]
PDB	1I4T [ SRS ]    1I4T [ PdbSum ],   1I4T [ IMB ]   1I4T [ RSDB ]
PDB	1MH1 [ SRS ]    1MH1 [ PdbSum ],   1MH1 [ IMB ]   1MH1 [ RSDB ]
PDB	1RYF [ SRS ]    1RYF [ PdbSum ],   1RYF [ IMB ]   1RYF [ RSDB ]
PDB	1RYH [ SRS ]    1RYH [ PdbSum ],   1RYH [ IMB ]   1RYH [ RSDB ]
PDB	2FJU [ SRS ]    2FJU [ PdbSum ],   2FJU [ IMB ]   2FJU [ RSDB ]
PDB	2H7V [ SRS ]    2H7V [ PdbSum ],   2H7V [ IMB ]   2H7V [ RSDB ]
PDB	2NZ8 [ SRS ]    2NZ8 [ PdbSum ],   2NZ8 [ IMB ]   2NZ8 [ RSDB ]
PDB	2P2L [ SRS ]    2P2L [ PdbSum ],   2P2L [ IMB ]   2P2L [ RSDB ]
PDB	2RMK [ SRS ]    2RMK [ PdbSum ],   2RMK [ IMB ]   2RMK [ RSDB ]
HPRD	03627
	Protein Interaction databases
DIP	P63000
IntAct	P63000
	Polymorphism : SNP, mutations, diseases
OMIM	602048    [ map ]
GENETests	602048
SNP	RAC1 [dbSNP-NCBI]
SNP	NM_006908 [SNP-NCI]
SNP	NM_018890 [SNP-NCI]
SNP	NM_198829 [SNP-NCI]
SNP	RAC1 [GeneSNPs - Utah]  RAC1] [HGBASE - SRS]
HAPMAP	RAC1 [HAPMAP]
COSMIC	RAC1 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	RAC1
Genetic Association	RAC1
CDC HuGE	RAC1
	General knowledge
Family Browser	RAC1 [UCSC Family Browser]
SOURCE	NM_006908
SOURCE	NM_018890
SOURCE	NM_198829
SMD	Hs.413812
SAGE	Hs.413812
GO	nucleotide binding [Amigo]  nucleotide binding
GO	GTPase activity [Amigo]  GTPase activity
GO	GTP binding [Amigo]  GTP binding
GO	intracellular [Amigo]  intracellular
GO	cytosol [Amigo]  cytosol
GO	plasma membrane [Amigo]  plasma membrane
GO	cell motility [Amigo]  cell motility
GO	inflammatory response [Amigo]  inflammatory response
GO	cell adhesion [Amigo]  cell adhesion
GO	small GTPase mediated signal transduction [Amigo]  small GTPase mediated signal transduction
GO	anatomical structure morphogenesis [Amigo]  anatomical structure morphogenesis
GO	regulation of hydrogen peroxide metabolic process [Amigo]  regulation of hydrogen peroxide metabolic process
GO	enzyme binding [Amigo]  enzyme binding
GO	lamellipodium biogenesis [Amigo]  lamellipodium biogenesis
GO	actin filament polymerization [Amigo]  actin filament polymerization
GO	GTP-dependent protein binding [Amigo]  GTP-dependent protein binding
GO	ruffle organization and biogenesis [Amigo]  ruffle organization and biogenesis
GO	positive regulation of Rho protein signal transduction [Amigo]  positive regulation of Rho protein signal transduction
GO	melanosome [Amigo]  melanosome
GO	negative regulation of receptor-mediated endocytosis [Amigo]  negative regulation of receptor-mediated endocytosis
GO	localization within membrane [Amigo]  localization within membrane
GO	regulation of respiratory burst [Amigo]  regulation of respiratory burst
BIOCARTA	Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling    [Genes]
BIOCARTA	Influence of Ras and Rho proteins on G1 to S Transition    [Genes]
BIOCARTA	Y branching of actin filaments    [Genes]
BIOCARTA	Agrin in Postsynaptic Differentiation    [Genes]
BIOCARTA	Tumor Suppressor Arf Inhibits Ribosomal Biogenesis    [Genes]
BIOCARTA	BCR Signaling Pathway    [Genes]
BIOCARTA	Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration    [Genes]
BIOCARTA	Transcription factor CREB and its extracellular signals    [Genes]
BIOCARTA	Phospholipids as signalling intermediaries    [Genes]
BIOCARTA	fMLP induced chemokine gene expression in HMC-1 cells    [Genes]
BIOCARTA	Role of MAL in Rho-Mediated Activation of SRF    [Genes]
BIOCARTA	MAPKinase Signaling Pathway    [Genes]
BIOCARTA	Ras-Independent pathway in NK cell-mediated cytotoxicity    [Genes]
BIOCARTA	p38 MAPK Signaling Pathway    [Genes]
BIOCARTA	Phosphoinositides and their downstream targets.    [Genes]
BIOCARTA	Links between Pyk2 and Map Kinases    [Genes]
BIOCARTA	Rac 1 cell motility signaling pathway    [Genes]
BIOCARTA	Ras Signaling Pathway    [Genes]
BIOCARTA	How does salmonella hijack a cell    [Genes]
BIOCARTA	T Cell Receptor Signaling Pathway    [Genes]
BIOCARTA	uCalpain and friends in Cell spread    [Genes]
KEGG	MAPK signaling pathway
KEGG	Wnt signaling pathway
KEGG	Axon guidance
KEGG	VEGF signaling pathway
KEGG	Focal adhesion
KEGG	Adherens junction
KEGG	Toll-like receptor signaling pathway
KEGG	Natural killer cell mediated cytotoxicity
KEGG	B cell receptor signaling pathway
KEGG	Fc epsilon RI signaling pathway
KEGG	Leukocyte transendothelial migration
KEGG	Regulation of actin cytoskeleton
KEGG	Epithelial cell signaling in Helicobacter pylori infection
KEGG	Colorectal cancer
PubGene	RAC1
TreeFam	RAC1
CTD	5879 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	RAC1 Related clones (RZPD - Berlin)
	PubMed
PubMed	336 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Dec 6 17:04:47 2008