RFK (riboflavin kinase)

2012-03-01  

Identity

HGNC
LOCATION
9q21.13
LOCUSID
ALIAS
RIFK
FUSION GENES

Other Information

Locus ID:

NCBI: 55312
MIM: 613010
HGNC: 30324
Ensembl: ENSG00000135002

Variants:

dbSNP: 55312
ClinVar: 55312
TCGA: ENSG00000135002
COSMIC: RFK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135002ENST00000376736Q969G6
ENSG00000135002ENST00000490113H7C4G0

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Riboflavin metabolismKEGGko00740
Riboflavin metabolismKEGGhsa00740
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Vitamin B2 (riboflavin) metabolismREACTOMER-HSA-196843

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10074escitalopramChemicalClinicalAnnotationassociatedPD
PA447207Depressive DisorderDiseaseClinicalAnnotationassociatedPD
PA449015citalopramChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
196414942009Riboflavin kinase couples TNF receptor 1 to NADPH oxidase.66
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
262882492015Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.17
145801992003Ligand binding-induced conformational changes in riboflavin kinase: structural basis for the ordered mechanism.12
221586152012Death receptors 4 and 5 activate Nox1 NADPH oxidase through riboflavin kinase to induce reactive oxygen species-mediated apoptotic cell death.11
213083512011Involvement of riboflavin kinase expression in cellular sensitivity against cisplatin.6

Citation

Dessen P

RFK (riboflavin kinase)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/43617/rfk