RIPK1 (receptor (TNFRSF)-interacting serine-threonine kinase 1)

Identity

Other names	FLJ39204
	RIP
	RIP1
HGNC	RIPK1
Location	6p25.2
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	RIPK1   10019
Entrez_Gene	RIPK1  8737  receptor (TNFRSF)-interacting serine-threonine kinase 1
	Cards
GeneCards	RIPK1
Ensembl	RIPK1 [Search_View]   ENSG00000137275 [Gene_View]
Genatlas	RIPK1
GeneLynx	RIPK1
eGenome	RIPK1
euGene	8737
	Genomic and cartography
GoldenPath	RIPK1  -  6p25.2   chr6:3022057-3060420 +  6p25.2   [Description]    (hg18-March_2006)
Ensembl	RIPK1 - 6p25.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	RIPK1
	Gene and transcription
Genbank	AB208926 [ ENTREZ ]
Genbank	AJ420482 [ ENTREZ ]
Genbank	AK096523 [ ENTREZ ]
Genbank	AK314176 [ ENTREZ ]
Genbank	BC126254 [ ENTREZ ]
RefSeq	NM_003804 [ SRS ]    NM_003804 [ ENTREZ ]
RefSeq	AC_000049 [ SRS ]    AC_000049 [ ENTREZ ]
RefSeq	AC_000138 [ SRS ]    AC_000138 [ ENTREZ ]
RefSeq	NC_000006 [ SRS ]    NC_000006 [ ENTREZ ]
RefSeq	NT_034880 [ SRS ]    NT_034880 [ ENTREZ ]
RefSeq	NW_001838972 [ SRS ]    NW_001838972 [ ENTREZ ]
RefSeq	NW_922984 [ SRS ]    NW_922984 [ ENTREZ ]
AceView	RIPK1 AceView - NCBI
Unigene	Hs.519842 [ SRS ]    Hs.519842 [ NCBI ]     HS519842 [ spliceNest ]
Fast-db	1165 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q13546 [ SRS]    Q13546 [ EXPASY ]     Q13546 [ INTERPRO ]     Q13546 [ UNIPROT ]
Prosite	PS50017 DEATH_DOMAIN [ SRS ]    PS50017 DEATH_DOMAIN [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Interpro	IPR000488 Death [ SRS ]    IPR000488 Death [ EBI ]
Interpro	IPR011029 DEATH_like [ SRS ]    IPR011029 DEATH_like [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
Interpro	IPR001245 Tyr_pkinase [ SRS ]    IPR001245 Tyr_pkinase [ EBI ]
CluSTr	Q13546
Pfam	PF00531 Death [ SRS ]    PF00531 Death [ Sanger ]    pfam00531 [ NCBI-CDD ]
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Smart	SM00005 DEATH [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	Q13546 RIPK1_HUMAN [ Domain structure ]   Q13546 RIPK1_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	Q13546
HPRD	04583
	Protein Interaction databases
DIP	Q13546
IntAct	Q13546
	Polymorphism : SNP, mutations, diseases
OMIM	603453    [ map ]
GENECLINICS	603453
SNP	RIPK1 [dbSNP-NCBI]
SNP	NM_003804 [SNP-NCI]
SNP	RIPK1 [GeneSNPs - Utah]  RIPK1] [HGBASE - SRS]
HAPMAP	RIPK1 [HAPMAP]
COSMIC	RIPK1 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	RIPK1
	General knowledge
Family Browser	RIPK1 [UCSC Family Browser]
SOURCE	NM_003804
SMD	Hs.519842
SAGE	Hs.519842
Enzyme	2.7.11.1 [ Enzyme-Expasy ]   2.7.11.1 [ Enzyme-SRS ]   2.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   2.7.11.1 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	protein serine/threonine kinase activity [Amigo]  protein serine/threonine kinase activity
GO	protein tyrosine kinase activity [Amigo]  protein tyrosine kinase activity
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	cytoplasm [Amigo]  cytoplasm
GO	cytosol [Amigo]  cytosol
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	apoptosis [Amigo]  apoptosis
GO	signal transduction [Amigo]  signal transduction
GO	activation of pro-apoptotic gene products [Amigo]  activation of pro-apoptotic gene products
GO	transferase activity [Amigo]  transferase activity
GO	positive regulation of I-kappaB kinase/NF-kappaB cascade [Amigo]  positive regulation of I-kappaB kinase/NF-kappaB cascade
KEGG	Apoptosis
PubGene	RIPK1
TreeFam	RIPK1
CTD	8737 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	RIPK1 Related clones (RZPD - Berlin)
	PubMed
PubMed	57 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:29:26 2008