RNASEL (ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent))

Identity

Other names	DKFZp781D08126
	MGC104972
	MGC133329
	PRCA1
	RNS4
HGNC	RNASEL
Location	1q25
Location_base_pair	Starts at 180809395 and ends at 180822731 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	RNASEL   10050
Entrez_Gene	RNASEL  6041  ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
	Cards
GeneCards	RNASEL
Ensembl	ENSG00000135828 [Gene_View]  RNASEL [Vega]
Genatlas	RNASEL
	Genomic and cartography
GoldenPath	RNASEL  -  1q25   chr1:180809395-180822731 -  1q25.3   [Description]    (hg18-March_2006)
Ensembl	RNASEL - 1q25.3 [CytoView]
NCBI	Mapview
OMIM	180435 Disease map [OMIM]
OMIM	601518 Disease map [OMIM]
HomoloGene	RNASEL
	Gene and transcription
Genbank	AK315231 [ ENTREZ ]
Genbank	BC090934 [ ENTREZ ]
Genbank	BC114433 [ ENTREZ ]
Genbank	BC115697 [ ENTREZ ]
Genbank	BQ003187 [ ENTREZ ]
RefSeq	NM_021133 [ SRS ]    NM_021133 [ ENTREZ ]
RefSeq	AC_000044 [ SRS ]    AC_000044 [ ENTREZ ]
RefSeq	AC_000133 [ SRS ]    AC_000133 [ ENTREZ ]
RefSeq	NC_000001 [ SRS ]    NC_000001 [ ENTREZ ]
RefSeq	NT_004487 [ SRS ]    NT_004487 [ ENTREZ ]
RefSeq	NW_001838533 [ SRS ]    NW_001838533 [ ENTREZ ]
RefSeq	NW_926128 [ SRS ]    NW_926128 [ ENTREZ ]
CCDS	RNASEL CCDS - NCBI
AceView	RNASEL AceView - NCBI
Unigene	Hs.518545 [ SRS ]    Hs.518545 [ NCBI ]
Fast-db	17629 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q05823 [ SRS]    Q05823 [ EXPASY ]     Q05823 [ INTERPRO ]     Q05823 [ UNIPROT ] Q05823 [ VarSplice FASTA ]
Prosite	PS50297 ANK_REP_REGION [ SRS ]    PS50297 ANK_REP_REGION [ Expasy ]
Prosite	PS50088 ANK_REPEAT [ SRS ]    PS50088 ANK_REPEAT [ Expasy ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Interpro	IPR002110 ANK [ SRS ]    IPR002110 ANK [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR006567 PUG [ SRS ]    IPR006567 PUG [ EBI ]
Interpro	IPR010513 RNase_L [ SRS ]    IPR010513 RNase_L [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
CluSTr	Q05823
Pfam	PF00023 Ank [ SRS ]    PF00023 Ank [ Sanger ]    pfam00023 [ NCBI-CDD ]
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Pfam	PF06479 Ribonuc_2-5A [ SRS ]    PF06479 Ribonuc_2-5A [ Sanger ]    pfam06479 [ NCBI-CDD ]
Smart	SM00248 ANK [EMBL]
Smart	SM00580 PUG [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	Q05823 RN5A_HUMAN [ Domain structure ]   Q05823 RN5A_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	Q05823
PDB	1WDY [ SRS ]    1WDY [ PdbSum ],   1WDY [ IMB ]   1WDY [ RSDB ]
HPRD	01590
	Protein Interaction databases
DIP	Q05823
IntAct	Q05823
	Polymorphism : SNP, mutations, diseases
OMIM	180435    [ map ]
OMIM	601518    [ map ]
GENETests	180435
GENETests	601518
SNP	RNASEL [dbSNP-NCBI]
SNP	NM_021133 [SNP-NCI]
SNP	RNASEL [GeneSNPs - Utah]  RNASEL] [HGBASE - SRS]
HAPMAP	RNASEL [HAPMAP]
COSMIC	RNASEL [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	RNASEL
Genetic Association	RNASEL
CDC HuGE	RNASEL
	General knowledge
Family Browser	RNASEL [UCSC Family Browser]
SOURCE	NM_021133
SMD	Hs.518545
SAGE	Hs.518545
Enzyme	3.1.26.- [ Enzyme-Expasy ]   3.1.26.- [ Enzyme-SRS ]   3.1.26.- [ IntEnz-EBI ]   3.1.26.- [ BRENDA ]   3.1.26.- [ KEGG ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	RNA binding [Amigo]  RNA binding
GO	protein kinase activity [Amigo]  protein kinase activity
GO	ATP binding [Amigo]  ATP binding
GO	cellular_component [Amigo]  cellular_component
GO	cytoplasm [Amigo]  cytoplasm
GO	mitochondrion [Amigo]  mitochondrion
GO	mRNA processing [Amigo]  mRNA processing
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	zinc ion binding [Amigo]  zinc ion binding
GO	hydrolase activity [Amigo]  hydrolase activity
GO	endoribonuclease activity, producing 5'-phosphomonoesters [Amigo]  endoribonuclease activity, producing 5'-phosphomonoesters
GO	metal ion binding [Amigo]  metal ion binding
PubGene	RNASEL
TreeFam	RNASEL
CTD	6041 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	RNASEL Related clones (RZPD - Berlin)
	PubMed
PubMed	66 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Dec 6 17:06:16 2008