RPS6KA3 (ribosomal protein S6 kinase A3)

2006-10-01  

Identity

HGNC
LOCATION
Xp22.12
LOCUSID
ALIAS
CLS,HU-3,ISPK-1,MAPKAPK1B,MRX19,RSK,RSK2,S6K-alpha3,p90-RSK2,pp90RSK2
FUSION GENES

Other Information

Locus ID:

NCBI: 6197
MIM: 300075
HGNC: 10432
Ensembl: ENSG00000177189

Variants:

dbSNP: 6197
ClinVar: 6197
TCGA: ENSG00000177189
COSMIC: RPS6KA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177189ENST00000379565P51812
ENSG00000177189ENST00000379565A0A384MDW3
ENSG00000177189ENST00000438357B1AXG2
ENSG00000177189ENST00000457145B1AXG1
ENSG00000177189ENST00000479809A0A2R8Y603
ENSG00000177189ENST00000642835B7ZB17
ENSG00000177189ENST00000643073A0A2R8YGB7
ENSG00000177189ENST00000643085B7ZB17
ENSG00000177189ENST00000643337B7ZB17
ENSG00000177189ENST00000643402B7ZB17
ENSG00000177189ENST00000644368B7ZB17
ENSG00000177189ENST00000644893B4DG22
ENSG00000177189ENST00000645268A0A2R8Y7S9
ENSG00000177189ENST00000645270B7ZB17
ENSG00000177189ENST00000646610B7ZB17
ENSG00000177189ENST00000647265B7ZB17

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
mTOR signaling pathwayKEGGko04150
Long-term potentiationKEGGko04720
Progesterone-mediated oocyte maturationKEGGko04914
MAPK signaling pathwayKEGGhsa04010
mTOR signaling pathwayKEGGhsa04150
Long-term potentiationKEGGhsa04720
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
Progesterone-mediated oocyte maturationKEGGhsa04914
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Activation of NMDA receptor upon glutamate binding and postsynaptic eventsREACTOMER-HSA-442755
Post NMDA receptor activation eventsREACTOMER-HSA-438064
CREB phosphorylation through the activation of RasREACTOMER-HSA-442742
RSK activationREACTOMER-HSA-444257
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 10 (TLR10) CascadeREACTOMER-HSA-168142
MyD88 cascade initiated on plasma membraneREACTOMER-HSA-975871
MAP kinase activation in TLR cascadeREACTOMER-HSA-450294
MAPK targets/ Nuclear events mediated by MAP kinasesREACTOMER-HSA-450282
ERK/MAPK targetsREACTOMER-HSA-198753
CREB phosphorylationREACTOMER-HSA-199920
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
Toll Like Receptor 5 (TLR5) CascadeREACTOMER-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Nuclear Events (kinase and transcription factor activation)REACTOMER-HSA-198725
Signaling by GPCRREACTOMER-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
Recycling pathway of L1REACTOMER-HSA-437239
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Senescence-Associated Secretory Phenotype (SASP)REACTOMER-HSA-2559582
Insulin resistanceKEGGhsa04931

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
187221212008Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation.138
197167942009RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells.89
191504322009betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis.86
158338402005The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation.72
187753312008Codependent functions of RSK2 and the apoptosis-promoting factor TIA-1 in stress granule assembly and cell survival.70
202340902010p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells.61
250025062014Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3.31
220317592011Mapping the transcriptional machinery of the IL-8 gene in human bronchial epithelial cells.30
172132022007RSK2 mediates muscle cell differentiation through regulation of NFAT3.29
261586302015Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2.29

Citation

Dessen P

RPS6KA3 (ribosomal protein S6 kinase A3)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43478/rps6ka3