SHOC2 (SHOC2 leucine rich repeat scaffold protein)

2010-03-01  

Identity

HGNC
SHOC2
LOCATION
10q25.2
LOCUSID
8036
ALIAS
NSLH1,SIAA0862,SOC2,SUR8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8036
MIM: 602775
HGNC: 15454
Ensembl: ENSG00000108061

Variants:

dbSNP: 8036
ClinVar: 8036
TCGA: ENSG00000108061
COSMIC: SHOC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108061ENST00000265277Q9UQ13
ENSG00000108061ENST00000369452Q9UQ13
ENSG00000108061ENST00000451838X6RI37

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ras signaling pathwayKEGGhsa04014

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
196846052009Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair.115
163013192006Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex.41
242112662013An MRAS, SHOC2, and SCRIB complex coordinates ERK pathway activation with polarity and tumorigenic growth.37
200515202010The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and Raf.28
230761512012SHOC2 and CRAF mediate ERK1/2 reactivation in mutant NRAS-mediated resistance to RAF inhibitor.22
226062622012Shoc2 is targeted to late endosomes and required for Erk1/2 activation in EGF-stimulated cells.17
250227562014HUWE1 is a molecular link controlling RAF-1 activity supported by the Shoc2 scaffold.14
200714682010Ras and calcium signaling pathways converge at Raf1 via the Shoc2 scaffold protein.12
208820352010Mutation analysis of the SHOC2 gene in Noonan-like syndrome and in hematologic malignancies.10
265194772015Spatial control of Shoc2-scaffold-mediated ERK1/2 signaling requires remodeling activity of the ATPase PSMC5.9

Citation

Dessen P

SHOC2 (SHOC2 leucine rich repeat scaffold protein)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51395/shoc2