SIM2 (single-minded homolog 2 (Drosophila))

Identity

Other names	MGC119447
	SIM
HGNC	SIM2
Location	21q22.2|21q22.13
Location_base_pair	Starts at 36993861 and ends at 37044380 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	SIM2   10883
Entrez_Gene	SIM2  6493  single-minded homolog 2 (Drosophila)
	Cards
GeneCards	SIM2
Ensembl	ENSG00000159263 [Gene_View]  SIM2 [Vega]
Genatlas	SIM2
	Genomic and cartography
GoldenPath	SIM2  -  21q22.2|21q22.13   chr21:36993861-37044380 +  21q22.13   [Description]    (hg18-March_2006)
Ensembl	SIM2 - 21q22.13 [CytoView]
NCBI	Mapview
OMIM	600892 Disease map [OMIM]
HomoloGene	SIM2
	Gene and transcription
Genbank	AI625864 [ ENTREZ ]
Genbank	AJ001858 [ ENTREZ ]
Genbank	AJ001859 [ ENTREZ ]
Genbank	BC110444 [ ENTREZ ]
Genbank	U80456 [ ENTREZ ]
RefSeq	NM_005069 [ SRS ]    NM_005069 [ ENTREZ ]
RefSeq	NM_009586 [ SRS ]    NM_009586 [ ENTREZ ]
RefSeq	AC_000064 [ SRS ]    AC_000064 [ ENTREZ ]
RefSeq	AC_000153 [ SRS ]    AC_000153 [ ENTREZ ]
RefSeq	NC_000021 [ SRS ]    NC_000021 [ ENTREZ ]
RefSeq	NT_011512 [ SRS ]    NT_011512 [ ENTREZ ]
RefSeq	NW_001838706 [ SRS ]    NW_001838706 [ ENTREZ ]
RefSeq	NW_927384 [ SRS ]    NW_927384 [ ENTREZ ]
CCDS	SIM2 CCDS - NCBI
AceView	SIM2 AceView - NCBI
Unigene	Hs.146186 [ SRS ]    Hs.146186 [ NCBI ]
Fast-db	2551 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q14190 [ SRS]    Q14190 [ EXPASY ]     Q14190 [ INTERPRO ]     Q14190 [ UNIPROT ] Q14190 [ VarSplice FASTA ]
Prosite	PS50888 HLH [ SRS ]    PS50888 HLH [ Expasy ]
Prosite	PS50113 PAC [ SRS ]    PS50113 PAC [ Expasy ]
Prosite	PS50112 PAS [ SRS ]    PS50112 PAS [ Expasy ]
Prosite	PS51302 SIM_C [ SRS ]    PS51302 SIM_C [ Expasy ]
Interpro	IPR001092 HLH_basic [ SRS ]    IPR001092 HLH_basic [ EBI ]
Interpro	IPR001067 Nuc_translocat [ SRS ]    IPR001067 Nuc_translocat [ EBI ]
Interpro	IPR001610 PAC [ SRS ]    IPR001610 PAC [ EBI ]
Interpro	IPR000014 PAS [ SRS ]    IPR000014 PAS [ EBI ]
Interpro	IPR000700 PAS-assoc_C [ SRS ]    IPR000700 PAS-assoc_C [ EBI ]
Interpro	IPR013655 PAS_3 [ SRS ]    IPR013655 PAS_3 [ EBI ]
Interpro	IPR013767 PAS_fold [ SRS ]    IPR013767 PAS_fold [ EBI ]
Interpro	IPR010578 SIM_C [ SRS ]    IPR010578 SIM_C [ EBI ]
CluSTr	Q14190
Pfam	PF00010 HLH [ SRS ]    PF00010 HLH [ Sanger ]    pfam00010 [ NCBI-CDD ]
Pfam	PF00989 PAS [ SRS ]    PF00989 PAS [ Sanger ]    pfam00989 [ NCBI-CDD ]
Pfam	PF08447 PAS_3 [ SRS ]    PF08447 PAS_3 [ Sanger ]    pfam08447 [ NCBI-CDD ]
Pfam	PF06621 SIM_C [ SRS ]    PF06621 SIM_C [ Sanger ]    pfam06621 [ NCBI-CDD ]
Smart	SM00353 HLH [EMBL]
Smart	SM00086 PAC [EMBL]
Smart	SM00091 PAS [EMBL]
Blocks	Q14190
HPRD	02935
	Protein Interaction databases
DIP	Q14190
IntAct	Q14190
	Polymorphism : SNP, mutations, diseases
OMIM	600892    [ map ]
GENETests	600892
SNP	SIM2 [dbSNP-NCBI]
SNP	NM_005069 [SNP-NCI]
SNP	NM_009586 [SNP-NCI]
SNP	SIM2 [GeneSNPs - Utah]  SIM2] [HGBASE - SRS]
HAPMAP	SIM2 [HAPMAP]
HGMD	SIM2
Genetic Association	SIM2
CDC HuGE	SIM2
	General knowledge
Family Browser	SIM2 [UCSC Family Browser]
SOURCE	NM_005069
SOURCE	NM_009586
SMD	Hs.146186
SAGE	Hs.146186
GO	negative regulation of transcription from RNA polymerase II promoter [Amigo]  negative regulation of transcription from RNA polymerase II promoter
GO	transcription factor activity [Amigo]  transcription factor activity
GO	signal transducer activity [Amigo]  signal transducer activity
GO	protein binding [Amigo]  protein binding
GO	nucleus [Amigo]  nucleus
GO	regulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
GO	signal transduction [Amigo]  signal transduction
GO	multicellular organismal development [Amigo]  multicellular organismal development
GO	nervous system development [Amigo]  nervous system development
GO	embryonic pattern specification [Amigo]  embryonic pattern specification
GO	transcription repressor activity [Amigo]  transcription repressor activity
GO	cell differentiation [Amigo]  cell differentiation
GO	lung development [Amigo]  lung development
GO	protein heterodimerization activity [Amigo]  protein heterodimerization activity
PubGene	SIM2
TreeFam	SIM2
CTD	6493 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	SIM2 Related clones (RZPD - Berlin)
	PubMed
PubMed	25 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Dec 6 17:08:29 2008