SIN3A (SIN3 transcription regulator family member A)

2003-02-01  

Identity

HGNC
LOCATION
15q24.2
LOCUSID
ALIAS
WITKOS
FUSION GENES

Other Information

Locus ID:

NCBI: 25942
MIM: 607776
HGNC: 19353
Ensembl: ENSG00000169375

Variants:

dbSNP: 25942
ClinVar: 25942
TCGA: ENSG00000169375
COSMIC: SIN3A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169375ENST00000360439Q96ST3
ENSG00000169375ENST00000394947Q96ST3
ENSG00000169375ENST00000394949Q96ST3
ENSG00000169375ENST00000562776H3BNZ3
ENSG00000169375ENST00000564778H3BP90
ENSG00000169375ENST00000565264H3BMA2
ENSG00000169375ENST00000567289H3BQL7
ENSG00000169375ENST00000568190H3BT34
ENSG00000169375ENST00000568309H3BQ76
ENSG00000169375ENST00000568431H3BNA0
ENSG00000169375ENST00000570115H3BQ88

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Huntington's diseaseKEGGko05016
Huntington's diseaseKEGGhsa05016
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Thyroid hormone signaling pathwayKEGGhsa04919
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
Gene ExpressionREACTOMER-HSA-74160
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Negative epigenetic regulation of rRNA expressionREACTOMER-HSA-5250941
NoRC negatively regulates rRNA expressionREACTOMER-HSA-427413
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
91501341997Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression.299
91501341997Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression.299
168059132006Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex.105
168059132006Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex.105
183164802008Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity.68
145597912003Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complex.55
153141772004Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP.47
243442582014Epstein-Barr virus nuclear antigen 3C binds to BATF/IRF4 or SPI1/IRF4 composite sites and recruits Sin3A to repress CDKN2A.46
161666252005Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex.41
196202902009Repression of ESR1 through actions of estrogen receptor alpha and Sin3A at the proximal promoter.40

Citation

Dessen P

SIN3A (SIN3 transcription regulator family member A)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42298/sin3a