SLC2A2 (solute carrier family 2 member 2)

2009-09-01  

Identity

HGNC
LOCATION
3q26.2
LOCUSID
ALIAS
GLUT2

Other Information

Locus ID:

NCBI: 6514
MIM: 138160
HGNC: 11006
Ensembl: ENSG00000163581

Variants:

dbSNP: 6514
ClinVar: 6514
TCGA: ENSG00000163581
COSMIC: SLC2A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163581ENST00000314251P11168
ENSG00000163581ENST00000461867C9J0E8
ENSG00000163581ENST00000469787F8WBJ2
ENSG00000163581ENST00000497642A0A0C4DH64

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Type II diabetes mellitusKEGGko04930
Maturity onset diabetes of the youngKEGGko04950
Type II diabetes mellitusKEGGhsa04930
Maturity onset diabetes of the youngKEGGhsa04950
Carbohydrate digestion and absorptionKEGGko04973
Carbohydrate digestion and absorptionKEGGhsa04973
Insulin secretionKEGGhsa04911
Prolactin signaling pathwayKEGGhsa04917
Prolactin signaling pathwayKEGGko04917
Central carbon metabolism in cancerKEGGhsa05230
Central carbon metabolism in cancerKEGGko05230
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Hexose transportREACTOMER-HSA-189200
Glucose transportREACTOMER-HSA-70153
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Facilitative Na+-independent glucose transportersREACTOMER-HSA-428790
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356
Developmental BiologyREACTOMER-HSA-1266738
Regulation of beta-cell developmentREACTOMER-HSA-186712
Regulation of gene expression in beta cellsREACTOMER-HSA-210745
Insulin resistanceKEGGhsa04931

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443886Diabetes MellitusDiseaseClinicalAnnotationassociatedPD
PA450395metforminChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
200818582010New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.925
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
145519162003Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action.71
192236552009GLUT2 mutations, translocation, and receptor function in diet sugar managing.61
219207902011GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: implications for understanding genetic association signals at this locus.48
204194492010Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people.43
205644762010Polyphenols and phenolic acids from strawberry and apple decrease glucose uptake and transport by human intestinal Caco-2 cells.33
275005232016Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.33
171924902007Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes.32
233969692013Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8.31

Citation

Dessen P

SLC2A2 (solute carrier family 2 member 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51069/slc2a2