SLC6A3 (solute carrier family 6 (neurotransmitter transporter, dopamine), member 3)

Identity

Other names	DAT
	DAT1
HGNC	SLC6A3
Location	5p15.3
Location_base_pair	Starts at 1445910 and ends at 1498538 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	SLC6A3   11049
Entrez_Gene	SLC6A3  6531  solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
	Cards
GeneCards	SLC6A3
Ensembl	ENSG00000142319 [Gene_View]  SLC6A3 [Vega]
Genatlas	SLC6A3
	Genomic and cartography
GoldenPath	SLC6A3  -  5p15.3   chr5:1445910-1498538 -  5p15.33   [Description]    (hg18-March_2006)
Ensembl	SLC6A3 - 5p15.33 [CytoView]
NCBI	Mapview
OMIM	125480 Disease map [OMIM]
OMIM	126455 Disease map [OMIM]
OMIM	143465 Disease map [OMIM]
OMIM	188890 Disease map [OMIM]
HomoloGene	SLC6A3
	Gene and transcription
Genbank	AK310589 [ ENTREZ ]
Genbank	BC132977 [ ENTREZ ]
Genbank	BC133003 [ ENTREZ ]
Genbank	EF174603 [ ENTREZ ]
Genbank	L24178 [ ENTREZ ]
RefSeq	NM_001044 [ SRS ]    NM_001044 [ ENTREZ ]
RefSeq	AC_000048 [ SRS ]    AC_000048 [ ENTREZ ]
RefSeq	AC_000137 [ SRS ]    AC_000137 [ ENTREZ ]
RefSeq	NC_000005 [ SRS ]    NC_000005 [ ENTREZ ]
RefSeq	NT_006576 [ SRS ]    NT_006576 [ ENTREZ ]
RefSeq	NW_001838923 [ SRS ]    NW_001838923 [ ENTREZ ]
RefSeq	NW_922518 [ SRS ]    NW_922518 [ ENTREZ ]
CCDS	SLC6A3 CCDS - NCBI
AceView	SLC6A3 AceView - NCBI
Unigene	Hs.406 [ SRS ]    Hs.406 [ NCBI ]
Fast-db	1100 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q01959 [ SRS]    Q01959 [ EXPASY ]     Q01959 [ INTERPRO ]     Q01959 [ UNIPROT ] Q01959 [ VarSplice FASTA ]
Prosite	PS00610 NA_NEUROTRAN_SYMP_1 [ SRS ]    PS00610 NA_NEUROTRAN_SYMP_1 [ Expasy ]
Prosite	PS00754 NA_NEUROTRAN_SYMP_2 [ SRS ]    PS00754 NA_NEUROTRAN_SYMP_2 [ Expasy ]
Prosite	PS50267 NA_NEUROTRAN_SYMP_3 [ SRS ]    PS50267 NA_NEUROTRAN_SYMP_3 [ Expasy ]
Interpro	IPR000175 Na/ntran_symport [ SRS ]    IPR000175 Na/ntran_symport [ EBI ]
Interpro	IPR002436 Na/ntran_symport_dopamine [ SRS ]    IPR002436 Na/ntran_symport_dopamine [ EBI ]
CluSTr	Q01959
Pfam	PF00209 SNF [ SRS ]    PF00209 SNF [ Sanger ]    pfam00209 [ NCBI-CDD ]
Prodom	PD000448 Na/ntran_symport[INRA-Toulouse]
Prodom	Q01959 SC6A3_HUMAN [ Domain structure ]   Q01959 SC6A3_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	Q01959
HPRD	00543
	Protein Interaction databases
DIP	Q01959
IntAct	Q01959
	Polymorphism : SNP, mutations, diseases
OMIM	125480    [ map ]
OMIM	126455    [ map ]
OMIM	143465    [ map ]
OMIM	188890    [ map ]
GENETests	125480
GENETests	126455
GENETests	143465
GENETests	188890
SNP	SLC6A3 [dbSNP-NCBI]
SNP	NM_001044 [SNP-NCI]
SNP	SLC6A3 [GeneSNPs - Utah]  SLC6A3] [HGBASE - SRS]
HAPMAP	SLC6A3 [HAPMAP]
HGMD	SLC6A3
Genetic Association	SLC6A3
CDC HuGE	SLC6A3
	General knowledge
Family Browser	SLC6A3 [UCSC Family Browser]
SOURCE	NM_001044
SMD	Hs.406
SAGE	Hs.406
GO	dopamine:sodium symporter activity [Amigo]  dopamine:sodium symporter activity
GO	protein binding [Amigo]  protein binding
GO	cytoplasm [Amigo]  cytoplasm
GO	plasma membrane [Amigo]  plasma membrane
GO	integral to plasma membrane [Amigo]  integral to plasma membrane
GO	lactation [Amigo]  lactation
GO	sensory perception of smell [Amigo]  sensory perception of smell
GO	locomotory behavior [Amigo]  locomotory behavior
GO	symporter activity [Amigo]  symporter activity
GO	monoamine transport [Amigo]  monoamine transport
GO	dopamine transport [Amigo]  dopamine transport
GO	adenohypophysis development [Amigo]  adenohypophysis development
GO	positive regulation of multicellular organism growth [Amigo]  positive regulation of multicellular organism growth
GO	regulation of dopamine metabolic process [Amigo]  regulation of dopamine metabolic process
GO	dopamine biosynthetic process [Amigo]  dopamine biosynthetic process
GO	dopamine catabolic process [Amigo]  dopamine catabolic process
GO	prepulse inhibition [Amigo]  prepulse inhibition
PubGene	SLC6A3
TreeFam	SLC6A3
CTD	6531 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	SLC6A3 Related clones (RZPD - Berlin)
	PubMed
PubMed	290 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Dec 6 17:09:03 2008