SOAT2 (sterol O-acyltransferase 2)

2007-07-01  

Identity

HGNC
LOCATION
12q13.13
LOCUSID
ALIAS
ACACT2,ACAT2,ARGP2

Other Information

Locus ID:

NCBI: 8435
MIM: 601311
HGNC: 11178
Ensembl: ENSG00000167780

Variants:

dbSNP: 8435
ClinVar: 8435
TCGA: ENSG00000167780
COSMIC: SOAT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167780ENST00000301466O75908
ENSG00000167780ENST00000542365O75908
ENSG00000167780ENST00000551896F8VPE9

Expression (GTEx)

0
1
2
3
4
5
6

Pathways

PathwaySourceExternal ID
Steroid biosynthesisKEGGko00100
Steroid biosynthesisKEGGhsa00100
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
LDL-mediated lipid transportREACTOMER-HSA-171052

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
154517932004ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver.56
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
153086312004Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells.28
198785692009Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis.28
186604892008Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.26
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
159923592005Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies.23
179198842007Prediction of genetic risk for dyslipidemia.19
146154112003Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) is induced in monocyte-derived macrophages: in vivo and in vitro studies.17

Citation

Dessen P

SOAT2 (sterol O-acyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47619/soat2