SOD1 (superoxide dismutase 1, soluble)

Identity

Other names	ALS
	ALS1
	IPOA
	SOD
	homodimer
HGNC	SOD1
Location	21q22.11
Location_base_pair	Starts at 31953806 and ends at 31963114 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	SOD1   11179
Entrez_Gene	SOD1  6647  superoxide dismutase 1, soluble
	Cards
GeneCards	SOD1
Ensembl	SOD1 [Search_View]   ENSG00000142168 [Gene_View]
Genatlas	SOD1
GeneLynx	SOD1
eGenome	SOD1
euGene	6647
	Genomic and cartography
GoldenPath	SOD1  -  21q22.11   chr21:31953806-31963114 +  21q22.11   [Description]    (hg18-March_2006)
Ensembl	SOD1 - 21q22.11 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	SOD1
	Gene and transcription
Genbank	AK312116 [ ENTREZ ]
Genbank	AV756797 [ ENTREZ ]
Genbank	AY049787 [ ENTREZ ]
Genbank	AY450286 [ ENTREZ ]
Genbank	BC001034 [ ENTREZ ]
RefSeq	NM_000454 [ SRS ]    NM_000454 [ ENTREZ ]
RefSeq	AC_000064 [ SRS ]    AC_000064 [ ENTREZ ]
RefSeq	AC_000153 [ SRS ]    AC_000153 [ ENTREZ ]
RefSeq	NC_000021 [ SRS ]    NC_000021 [ ENTREZ ]
RefSeq	NT_011512 [ SRS ]    NT_011512 [ ENTREZ ]
RefSeq	NW_001838706 [ SRS ]    NW_001838706 [ ENTREZ ]
RefSeq	NW_927384 [ SRS ]    NW_927384 [ ENTREZ ]
AceView	SOD1 AceView - NCBI
Unigene	Hs.443914 [ SRS ]    Hs.443914 [ NCBI ]     HS443914 [ spliceNest ]
Fast-db	1592 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P00441 [ SRS]    P00441 [ EXPASY ]     P00441 [ INTERPRO ]     P00441 [ UNIPROT ]
Prosite	PS00087 SOD_CU_ZN_1 [ SRS ]    PS00087 SOD_CU_ZN_1 [ Expasy ]
Prosite	PS00332 SOD_CU_ZN_2 [ SRS ]    PS00332 SOD_CU_ZN_2 [ Expasy ]
Interpro	IPR001424 SOD_Cu_Zn [ SRS ]    IPR001424 SOD_Cu_Zn [ EBI ]
CluSTr	P00441
Pfam	PF00080 Sod_Cu [ SRS ]    PF00080 Sod_Cu [ Sanger ]    pfam00080 [ NCBI-CDD ]
Prodom	PD000469 SOD_CU_ZN[INRA-Toulouse]
Prodom	P00441 SODC_HUMAN [ Domain structure ]   P00441 SODC_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P00441
PDB	1AZV [ SRS ]    1AZV [ PdbSum ],   1AZV [ IMB ]   1AZV [ RSDB ]
PDB	1BA9 [ SRS ]    1BA9 [ PdbSum ],   1BA9 [ IMB ]   1BA9 [ RSDB ]
PDB	1DSW [ SRS ]    1DSW [ PdbSum ],   1DSW [ IMB ]   1DSW [ RSDB ]
PDB	1FUN [ SRS ]    1FUN [ PdbSum ],   1FUN [ IMB ]   1FUN [ RSDB ]
PDB	1HL4 [ SRS ]    1HL4 [ PdbSum ],   1HL4 [ IMB ]   1HL4 [ RSDB ]
PDB	1HL5 [ SRS ]    1HL5 [ PdbSum ],   1HL5 [ IMB ]   1HL5 [ RSDB ]
PDB	1KMG [ SRS ]    1KMG [ PdbSum ],   1KMG [ IMB ]   1KMG [ RSDB ]
PDB	1L3N [ SRS ]    1L3N [ PdbSum ],   1L3N [ IMB ]   1L3N [ RSDB ]
PDB	1MFM [ SRS ]    1MFM [ PdbSum ],   1MFM [ IMB ]   1MFM [ RSDB ]
PDB	1N18 [ SRS ]    1N18 [ PdbSum ],   1N18 [ IMB ]   1N18 [ RSDB ]
PDB	1N19 [ SRS ]    1N19 [ PdbSum ],   1N19 [ IMB ]   1N19 [ RSDB ]
PDB	1OEZ [ SRS ]    1OEZ [ PdbSum ],   1OEZ [ IMB ]   1OEZ [ RSDB ]
PDB	1OZT [ SRS ]    1OZT [ PdbSum ],   1OZT [ IMB ]   1OZT [ RSDB ]
PDB	1OZU [ SRS ]    1OZU [ PdbSum ],   1OZU [ IMB ]   1OZU [ RSDB ]
PDB	1P1V [ SRS ]    1P1V [ PdbSum ],   1P1V [ IMB ]   1P1V [ RSDB ]
PDB	1PTZ [ SRS ]    1PTZ [ PdbSum ],   1PTZ [ IMB ]   1PTZ [ RSDB ]
PDB	1PU0 [ SRS ]    1PU0 [ PdbSum ],   1PU0 [ IMB ]   1PU0 [ RSDB ]
PDB	1RK7 [ SRS ]    1RK7 [ PdbSum ],   1RK7 [ IMB ]   1RK7 [ RSDB ]
PDB	1SOS [ SRS ]    1SOS [ PdbSum ],   1SOS [ IMB ]   1SOS [ RSDB ]
PDB	1SPD [ SRS ]    1SPD [ PdbSum ],   1SPD [ IMB ]   1SPD [ RSDB ]
PDB	1UXL [ SRS ]    1UXL [ PdbSum ],   1UXL [ IMB ]   1UXL [ RSDB ]
PDB	1UXM [ SRS ]    1UXM [ PdbSum ],   1UXM [ IMB ]   1UXM [ RSDB ]
PDB	2AF2 [ SRS ]    2AF2 [ PdbSum ],   2AF2 [ IMB ]   2AF2 [ RSDB ]
PDB	2C9S [ SRS ]    2C9S [ PdbSum ],   2C9S [ IMB ]   2C9S [ RSDB ]
PDB	2C9U [ SRS ]    2C9U [ PdbSum ],   2C9U [ IMB ]   2C9U [ RSDB ]
PDB	2C9V [ SRS ]    2C9V [ PdbSum ],   2C9V [ IMB ]   2C9V [ RSDB ]
PDB	2GBT [ SRS ]    2GBT [ PdbSum ],   2GBT [ IMB ]   2GBT [ RSDB ]
PDB	2GBU [ SRS ]    2GBU [ PdbSum ],   2GBU [ IMB ]   2GBU [ RSDB ]
PDB	2GBV [ SRS ]    2GBV [ PdbSum ],   2GBV [ IMB ]   2GBV [ RSDB ]
PDB	2NNX [ SRS ]    2NNX [ PdbSum ],   2NNX [ IMB ]   2NNX [ RSDB ]
PDB	2R27 [ SRS ]    2R27 [ PdbSum ],   2R27 [ IMB ]   2R27 [ RSDB ]
PDB	2V0A [ SRS ]    2V0A [ PdbSum ],   2V0A [ IMB ]   2V0A [ RSDB ]
PDB	2VR6 [ SRS ]    2VR6 [ PdbSum ],   2VR6 [ IMB ]   2VR6 [ RSDB ]
PDB	2VR7 [ SRS ]    2VR7 [ PdbSum ],   2VR7 [ IMB ]   2VR7 [ RSDB ]
PDB	2VR8 [ SRS ]    2VR8 [ PdbSum ],   2VR8 [ IMB ]   2VR8 [ RSDB ]
PDB	2YQV [ SRS ]    2YQV [ PdbSum ],   2YQV [ IMB ]   2YQV [ RSDB ]
PDB	2YQW [ SRS ]    2YQW [ PdbSum ],   2YQW [ IMB ]   2YQW [ RSDB ]
PDB	2YQX [ SRS ]    2YQX [ PdbSum ],   2YQX [ IMB ]   2YQX [ RSDB ]
PDB	3CQP [ SRS ]    3CQP [ PdbSum ],   3CQP [ IMB ]   3CQP [ RSDB ]
PDB	3CQQ [ SRS ]    3CQQ [ PdbSum ],   3CQQ [ IMB ]   3CQQ [ RSDB ]
PDB	4SOD [ SRS ]    4SOD [ PdbSum ],   4SOD [ IMB ]   4SOD [ RSDB ]
HPRD	00937
	Protein Interaction databases
DIP	P00441
IntAct	P00441
	Polymorphism : SNP, mutations, diseases
OMIM	105400;147450    [ map ]
GENECLINICS	105400;147450
SNP	SOD1 [dbSNP-NCBI]
SNP	NM_000454 [SNP-NCI]
SNP	SOD1 [GeneSNPs - Utah]  SOD1] [HGBASE - SRS]
HAPMAP	SOD1 [HAPMAP]
HGMD	SOD1
	General knowledge
Family Browser	SOD1 [UCSC Family Browser]
SOURCE	NM_000454
SMD	Hs.443914
SAGE	Hs.443914
GO	activation of MAPK activity [Amigo]  activation of MAPK activity
GO	response to superoxide [Amigo]  response to superoxide
GO	ovarian follicle development [Amigo]  ovarian follicle development
GO	positive regulation of cytokine production [Amigo]  positive regulation of cytokine production
GO	placenta development [Amigo]  placenta development
GO	retina homeostasis [Amigo]  retina homeostasis
GO	myeloid cell homeostasis [Amigo]  myeloid cell homeostasis
GO	superoxide dismutase activity [Amigo]  superoxide dismutase activity
GO	copper ion binding [Amigo]  copper ion binding
GO	extracellular space [Amigo]  extracellular space
GO	nucleus [Amigo]  nucleus
GO	cytoplasm [Amigo]  cytoplasm
GO	mitochondrion [Amigo]  mitochondrion
GO	mitochondrial matrix [Amigo]  mitochondrial matrix
GO	peroxisome [Amigo]  peroxisome
GO	cytosol [Amigo]  cytosol
GO	plasma membrane [Amigo]  plasma membrane
GO	double-strand break repair [Amigo]  double-strand break repair
GO	DNA fragmentation during apoptosis [Amigo]  DNA fragmentation during apoptosis
GO	glutathione metabolic process [Amigo]  glutathione metabolic process
GO	cellular iron ion homeostasis [Amigo]  cellular iron ion homeostasis
GO	response to oxidative stress [Amigo]  response to oxidative stress
GO	spermatogenesis [Amigo]  spermatogenesis
GO	embryo implantation [Amigo]  embryo implantation
GO	embryo implantation [Amigo]  embryo implantation
GO	cell aging [Amigo]  cell aging
GO	cell aging [Amigo]  cell aging
GO	sensory perception of sound [Amigo]  sensory perception of sound
GO	locomotory behavior [Amigo]  locomotory behavior
GO	regulation of blood pressure [Amigo]  regulation of blood pressure
GO	zinc ion binding [Amigo]  zinc ion binding
GO	response to heat [Amigo]  response to heat
GO	antioxidant activity [Amigo]  antioxidant activity
GO	oxidoreductase activity [Amigo]  oxidoreductase activity
GO	transmission of nerve impulse [Amigo]  transmission of nerve impulse
GO	removal of superoxide radicals [Amigo]  removal of superoxide radicals
GO	protein phosphatase 2B binding [Amigo]  protein phosphatase 2B binding
GO	extracellular matrix [Amigo]  extracellular matrix
GO	cytoplasmic vesicle [Amigo]  cytoplasmic vesicle
GO	myelin maintenance in the peripheral nervous system [Amigo]  myelin maintenance in the peripheral nervous system
GO	dendrite cytoplasm [Amigo]  dendrite cytoplasm
GO	regulation of T cell differentiation in the thymus [Amigo]  regulation of T cell differentiation in the thymus
GO	regulation of multicellular organism growth [Amigo]  regulation of multicellular organism growth
GO	response to drug [Amigo]  response to drug
GO	response to hydrogen peroxide [Amigo]  response to hydrogen peroxide
GO	protein homodimerization activity [Amigo]  protein homodimerization activity
GO	cell soma [Amigo]  cell soma
GO	positive regulation of apoptosis [Amigo]  positive regulation of apoptosis
GO	positive regulation of catalytic activity [Amigo]  positive regulation of catalytic activity
GO	protein complex [Amigo]  protein complex
GO	negative regulation of neuron apoptosis [Amigo]  negative regulation of neuron apoptosis
GO	response to ethanol [Amigo]  response to ethanol
GO	negative regulation of cholesterol biosynthetic process [Amigo]  negative regulation of cholesterol biosynthetic process
GO	regulation of protein kinase activity [Amigo]  regulation of protein kinase activity
GO	regulation of organ growth [Amigo]  regulation of organ growth
GO	muscle maintenance [Amigo]  muscle maintenance
GO	metal ion binding [Amigo]  metal ion binding
GO	thymus development [Amigo]  thymus development
GO	response to axon injury [Amigo]  response to axon injury
GO	hydrogen peroxide biosynthetic process [Amigo]  hydrogen peroxide biosynthetic process
GO	hydrogen peroxide biosynthetic process [Amigo]  hydrogen peroxide biosynthetic process
GO	chaperone binding [Amigo]  chaperone binding
GO	regulation of mitochondrial membrane potential [Amigo]  regulation of mitochondrial membrane potential
GO	oxidation reduction [Amigo]  oxidation reduction
GO	heart contraction [Amigo]  heart contraction
GO	neurofilament cytoskeleton organization and biogenesis [Amigo]  neurofilament cytoskeleton organization and biogenesis
GO	relaxation of vascular smooth muscle [Amigo]  relaxation of vascular smooth muscle
GO	auditory receptor cell stereocilium organization and biogenesis [Amigo]  auditory receptor cell stereocilium organization and biogenesis
BIOCARTA	Cardiac Protection Against ROS    [Genes]
BIOCARTA	Free Radical Induced Apoptosis    [Genes]
KEGG	Neurodegenerative Disorders
KEGG	Amyotrophic lateral sclerosis (ALS)
PubGene	SOD1
TreeFam	SOD1
CTD	6647 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	SOD1 Related clones (RZPD - Berlin)
	PubMed
PubMed	377 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 15:02:38 2008