SRD5A1 (steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1))

Identity

Other names	-
HGNC	SRD5A1
Location	5p15.31
Location_base_pair	Starts at 6686500 and ends at 6722675 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	SRD5A1   11284
Entrez_Gene	SRD5A1  6715  steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
	Cards
GeneCards	SRD5A1
Ensembl	SRD5A1 [Search_View]   ENSG00000145545 [Gene_View]
Genatlas	SRD5A1
GeneLynx	SRD5A1
eGenome	SRD5A1
euGene	6715
	Genomic and cartography
GoldenPath	SRD5A1  -  5p15.31   chr5:6686500-6722675 +  5p15.31   [Description]    (hg18-March_2006)
Ensembl	SRD5A1 - 5p15.31 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	SRD5A1
	Gene and transcription
Genbank	AF052126 [ ENTREZ ]
Genbank	AF113128 [ ENTREZ ]
Genbank	AK313070 [ ENTREZ ]
Genbank	BC006373 [ ENTREZ ]
Genbank	BC007033 [ ENTREZ ]
RefSeq	NM_001047 [ SRS ]    NM_001047 [ ENTREZ ]
RefSeq	AC_000048 [ SRS ]    AC_000048 [ ENTREZ ]
RefSeq	AC_000137 [ SRS ]    AC_000137 [ ENTREZ ]
RefSeq	NC_000005 [ SRS ]    NC_000005 [ ENTREZ ]
RefSeq	NT_006576 [ SRS ]    NT_006576 [ ENTREZ ]
RefSeq	NW_001838926 [ SRS ]    NW_001838926 [ ENTREZ ]
RefSeq	NW_922518 [ SRS ]    NW_922518 [ ENTREZ ]
AceView	SRD5A1 AceView - NCBI
Unigene	Hs.552 [ SRS ]    Hs.552 [ NCBI ]     HS552 [ spliceNest ]
Fast-db	1246 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P18405 [ SRS]    P18405 [ EXPASY ]     P18405 [ INTERPRO ]     P18405 [ UNIPROT ]
Prosite	PS50244 S5A_REDUCTASE [ SRS ]    PS50244 S5A_REDUCTASE [ Expasy ]
Interpro	IPR016636 3-oxo-5-alpha-steroid_4-DH [ SRS ]    IPR016636 3-oxo-5-alpha-steroid_4-DH [ EBI ]
Interpro	IPR001104 3-oxo-5_a-steroid_4-DHase_C [ SRS ]    IPR001104 3-oxo-5_a-steroid_4-DHase_C [ EBI ]
CluSTr	P18405
Pfam	PF02544 Steroid_dh [ SRS ]    PF02544 Steroid_dh [ Sanger ]    pfam02544 [ NCBI-CDD ]
Blocks	P18405
HPRD	01699
	Protein Interaction databases
DIP	P18405
IntAct	P18405
	Polymorphism : SNP, mutations, diseases
OMIM	184753    [ map ]
GENECLINICS	184753
SNP	SRD5A1 [dbSNP-NCBI]
SNP	NM_001047 [SNP-NCI]
SNP	SRD5A1 [GeneSNPs - Utah]  SRD5A1] [HGBASE - SRS]
HAPMAP	SRD5A1 [HAPMAP]
HGMD	SRD5A1
	General knowledge
Family Browser	SRD5A1 [UCSC Family Browser]
SOURCE	NM_001047
SMD	Hs.552
SAGE	Hs.552
Enzyme	1.3.99.5 [ Enzyme-Expasy ]   1.3.99.5 [ Enzyme-SRS ]   1.3.99.5 [ IntEnz-EBI ]   1.3.99.5 [ BRENDA ]   1.3.99.5 [ KEGG ]   1.3.99.5 [ WIT ]
GO	3-oxo-5-alpha-steroid 4-dehydrogenase activity [Amigo]  3-oxo-5-alpha-steroid 4-dehydrogenase activity
GO	cytoplasm [Amigo]  cytoplasm
GO	endoplasmic reticulum [Amigo]  endoplasmic reticulum
GO	endoplasmic reticulum membrane [Amigo]  endoplasmic reticulum membrane
GO	microsome [Amigo]  microsome
GO	lipid metabolic process [Amigo]  lipid metabolic process
GO	androgen biosynthetic process [Amigo]  androgen biosynthetic process
GO	sex determination [Amigo]  sex determination
GO	steroid metabolic process [Amigo]  steroid metabolic process
GO	electron carrier activity [Amigo]  electron carrier activity
GO	membrane [Amigo]  membrane
GO	integral to membrane [Amigo]  integral to membrane
GO	oxidoreductase activity, acting on the CH-CH group of donors [Amigo]  oxidoreductase activity, acting on the CH-CH group of donors
GO	cell differentiation [Amigo]  cell differentiation
GO	oxidation reduction [Amigo]  oxidation reduction
KEGG	Bile acid biosynthesis
KEGG	Androgen and estrogen metabolism
PubGene	SRD5A1
TreeFam	SRD5A1
CTD	6715 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	SRD5A1 Related clones (RZPD - Berlin)
	PubMed
PubMed	42 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Tue Oct 14 20:56:23 2008