SRD5A2 (steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2))

Identity

Other names	MGC138457
HGNC	SRD5A2
Location	2p23.1
Location_base_pair	Starts at 31603160 and ends at 31659544 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	SRD5A2   11285
Entrez_Gene	SRD5A2  6716  steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
	Cards
GeneCards	SRD5A2
Ensembl	SRD5A2 [Search_View]   ENSG00000049319 [Gene_View]
Genatlas	SRD5A2
GeneLynx	SRD5A2
eGenome	SRD5A2
euGene	6716
	Genomic and cartography
GoldenPath	SRD5A2  -  2p23.1   chr2:31603160-31659544 -  2p23.1   [Description]    (hg18-March_2006)
Ensembl	SRD5A2 - 2p23.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	SRD5A2
	Gene and transcription
Genbank	AK307235 [ ENTREZ ]
Genbank	AK316597 [ ENTREZ ]
Genbank	BC112252 [ ENTREZ ]
Genbank	BC113641 [ ENTREZ ]
Genbank	EF560740 [ ENTREZ ]
RefSeq	NM_000348 [ SRS ]    NM_000348 [ ENTREZ ]
RefSeq	AC_000045 [ SRS ]    AC_000045 [ ENTREZ ]
RefSeq	AC_000134 [ SRS ]    AC_000134 [ ENTREZ ]
RefSeq	NC_000002 [ SRS ]    NC_000002 [ ENTREZ ]
RefSeq	NT_022184 [ SRS ]    NT_022184 [ ENTREZ ]
RefSeq	NW_001838769 [ SRS ]    NW_001838769 [ ENTREZ ]
RefSeq	NW_927719 [ SRS ]    NW_927719 [ ENTREZ ]
AceView	SRD5A2 AceView - NCBI
Unigene	Hs.458345 [ SRS ]    Hs.458345 [ NCBI ]     HS458345 [ spliceNest ]
	Protein : pattern, domain, 3D structure
SwissProt	P31213 [ SRS]    P31213 [ EXPASY ]     P31213 [ INTERPRO ]     P31213 [ UNIPROT ]
Prosite	PS50244 S5A_REDUCTASE [ SRS ]    PS50244 S5A_REDUCTASE [ Expasy ]
Interpro	IPR016636 3-oxo-5-alpha-steroid_4-DH [ SRS ]    IPR016636 3-oxo-5-alpha-steroid_4-DH [ EBI ]
Interpro	IPR001104 3-oxo-5_a-steroid_4-DHase_C [ SRS ]    IPR001104 3-oxo-5_a-steroid_4-DHase_C [ EBI ]
CluSTr	P31213
Pfam	PF02544 Steroid_dh [ SRS ]    PF02544 Steroid_dh [ Sanger ]    pfam02544 [ NCBI-CDD ]
Blocks	P31213
HPRD	07390
	Protein Interaction databases
DIP	P31213
IntAct	P31213
	Polymorphism : SNP, mutations, diseases
OMIM	264600;607306    [ map ]
GENECLINICS	264600;607306
SNP	SRD5A2 [dbSNP-NCBI]
SNP	NM_000348 [SNP-NCI]
SNP	SRD5A2 [GeneSNPs - Utah]  SRD5A2] [HGBASE - SRS]
HAPMAP	SRD5A2 [HAPMAP]
HGMD	SRD5A2
	General knowledge
Family Browser	SRD5A2 [UCSC Family Browser]
SOURCE	NM_000348
SMD	Hs.458345
SAGE	Hs.458345
Enzyme	1.3.99.5 [ Enzyme-Expasy ]   1.3.99.5 [ Enzyme-SRS ]   1.3.99.5 [ IntEnz-EBI ]   1.3.99.5 [ BRENDA ]   1.3.99.5 [ KEGG ]   1.3.99.5 [ WIT ]
GO	3-oxo-5-alpha-steroid 4-dehydrogenase activity [Amigo]  3-oxo-5-alpha-steroid 4-dehydrogenase activity
GO	cytoplasm [Amigo]  cytoplasm
GO	endoplasmic reticulum [Amigo]  endoplasmic reticulum
GO	endoplasmic reticulum membrane [Amigo]  endoplasmic reticulum membrane
GO	microsome [Amigo]  microsome
GO	lipid metabolic process [Amigo]  lipid metabolic process
GO	androgen biosynthetic process [Amigo]  androgen biosynthetic process
GO	steroid catabolic process [Amigo]  steroid catabolic process
GO	cell-cell signaling [Amigo]  cell-cell signaling
GO	sex determination [Amigo]  sex determination
GO	male gonad development [Amigo]  male gonad development
GO	sterol 5-alpha reductase activity [Amigo]  sterol 5-alpha reductase activity
GO	response to organic substance [Amigo]  response to organic substance
GO	membrane [Amigo]  membrane
GO	integral to membrane [Amigo]  integral to membrane
GO	cell differentiation [Amigo]  cell differentiation
GO	male genitalia development [Amigo]  male genitalia development
GO	response to drug [Amigo]  response to drug
GO	response to peptide hormone stimulus [Amigo]  response to peptide hormone stimulus
GO	response to steroid hormone stimulus [Amigo]  response to steroid hormone stimulus
GO	oxidation reduction [Amigo]  oxidation reduction
KEGG	Bile acid biosynthesis
KEGG	Androgen and estrogen metabolism
PubGene	SRD5A2
TreeFam	SRD5A2
CTD	6716 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	SRD5A2 Related clones (RZPD - Berlin)
	PubMed
PubMed	115 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 15:03:01 2008