SRF (serum response factor)

2003-02-01  

Identity

HGNC
LOCATION
6p21.1
LOCUSID
ALIAS
MCM1
FUSION GENES

Other Information

Locus ID:

NCBI: 6722
MIM: 600589
HGNC: 11291
Ensembl: ENSG00000112658

Variants:

dbSNP: 6722
ClinVar: 6722
TCGA: ENSG00000112658
COSMIC: SRF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112658ENST00000265354P11831
ENSG00000112658ENST00000265354A0A024RD16

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
127883742003Serum response factor: toggling between disparate programs of gene expression.215
191986012009Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis.162
190989032009SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells.100
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
172153562007Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype.76
196871462009Elucidation of the ELK1 target gene network reveals a role in the coordinate regulation of core components of the gene regulation machinery.68
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
256817332015Inhibition of myocardin-related transcription factor/serum response factor signaling decreases lung fibrosis and promotes mesenchymal cell apoptosis.61
219981252012Downregulation of the serum response factor/miR-1 axis in the quadriceps of patients with COPD.55
191513202009Critical role of serum response factor in pulmonary myofibroblast differentiation induced by TGF-beta.52

Citation

Dessen P

SRF (serum response factor)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42388/srf