SUV39H1 (suppressor of variegation 3-9 homolog 1)

2007-02-01  

Identity

HGNC
LOCATION
Xp11.23
LOCUSID
ALIAS
H3-K9-HMTase 1,KMT1A,MG44,SUV39H
FUSION GENES

Other Information

Locus ID:

NCBI: 6839
MIM: 300254
HGNC: 11479
Ensembl: ENSG00000101945

Variants:

dbSNP: 6839
ClinVar: 6839
TCGA: ENSG00000101945
COSMIC: SUV39H1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101945ENST00000337852O43463
ENSG00000101945ENST00000376687O43463

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Lysine degradationKEGGko00310
Lysine degradationKEGGhsa00310
Gene ExpressionREACTOMER-HSA-74160
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Negative epigenetic regulation of rRNA expressionREACTOMER-HSA-5250941
SIRT1 negatively regulates rRNA ExpressionREACTOMER-HSA-427359
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
PKMTs methylate histone lysinesREACTOMER-HSA-3214841

References

Pubmed IDYearTitleCitations
118675402002Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing.228
172454322007Suv39H1 and HP1gamma are responsible for chromatin-mediated HIV-1 transcriptional silencing and post-integration latency.151
127116032003Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression.79
225622462013Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer.70
215048322011Stabilization of Suv39H1 by SirT1 is part of oxidative stress response and ensures genome protection.65
152204032004Accumulation of heterochromatin components on the terminal repeat sequence of Kaposi's sarcoma-associated herpesvirus mediated by the latency-associated nuclear antigen.53
195819322009p21(WAF1) gene promoter is epigenetically silenced by CTIP2 and SUV39H1.51
192182362009Inhibition of SUV39H1 methyltransferase activity by DBC1.45
235092802013Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability.45
127892592003pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer.41

Citation

Dessen P

SUV39H1 (suppressor of variegation 3-9 homolog 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43860/suv39h1