TCF4 (transcription factor 4)

2004-05-01  

Identity

HGNC
LOCATION
18q21.2
LOCUSID
ALIAS
CDG2T,E2-2,FECD3,ITF-2,ITF2,PTHS,SEF-2,SEF2,SEF2-1,SEF2-1A,SEF2-1B,SEF2-1D,TCF-4,bHLHb19
FUSION GENES

Other Information

Locus ID:

NCBI: 6925
MIM: 602272
HGNC: 11634
Ensembl: ENSG00000196628

Variants:

dbSNP: 6925
ClinVar: 6925
TCGA: ENSG00000196628
COSMIC: TCF4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196628ENST00000354452P15884
ENSG00000196628ENST00000356073P15884
ENSG00000196628ENST00000356073A0A024R2C0
ENSG00000196628ENST00000398339E9PH57
ENSG00000196628ENST00000457482P15884
ENSG00000196628ENST00000537578P15884
ENSG00000196628ENST00000537856P15884
ENSG00000196628ENST00000540999P15884
ENSG00000196628ENST00000543082P15884
ENSG00000196628ENST00000544241P15884
ENSG00000196628ENST00000561831P15884
ENSG00000196628ENST00000561992P15884
ENSG00000196628ENST00000562030H3BRF7
ENSG00000196628ENST00000562543G0LNT4
ENSG00000196628ENST00000562607H3BNZ2
ENSG00000196628ENST00000562638A0A1B0GXH5
ENSG00000196628ENST00000562847H3BNI2
ENSG00000196628ENST00000563824H3BTC3
ENSG00000196628ENST00000563888H3BUQ3
ENSG00000196628ENST00000564228P15884
ENSG00000196628ENST00000564343H3BMC8
ENSG00000196628ENST00000564403H3BTP3
ENSG00000196628ENST00000564999P15884
ENSG00000196628ENST00000564999A0A024R2C0
ENSG00000196628ENST00000565018P15884
ENSG00000196628ENST00000565124H3BT95
ENSG00000196628ENST00000565393H3BML7
ENSG00000196628ENST00000565908A0A075B723
ENSG00000196628ENST00000566279P15884
ENSG00000196628ENST00000566286P15884
ENSG00000196628ENST00000566514H3BT24
ENSG00000196628ENST00000566777H3BTM9
ENSG00000196628ENST00000567880P15884
ENSG00000196628ENST00000568147H3BP59
ENSG00000196628ENST00000568169H3BTZ0
ENSG00000196628ENST00000568186G0LNT7
ENSG00000196628ENST00000568673P15884
ENSG00000196628ENST00000568740H3BPJ7
ENSG00000196628ENST00000569012H3BPG3
ENSG00000196628ENST00000569357H3BME8
ENSG00000196628ENST00000570146K7ESI6
ENSG00000196628ENST00000570177P15884
ENSG00000196628ENST00000570287P15884
ENSG00000196628ENST00000590810A0A0E3D6N2
ENSG00000196628ENST00000616053P15884
ENSG00000196628ENST00000625925A0A0D9SGE4
ENSG00000196628ENST00000626425A0A0D9SEX8
ENSG00000196628ENST00000626584P15884
ENSG00000196628ENST00000626595A0A0D9SGE5
ENSG00000196628ENST00000626631A0A0D9SGH7
ENSG00000196628ENST00000627320A0A0D9SGJ4
ENSG00000196628ENST00000627685A0A0D9SG61
ENSG00000196628ENST00000627784A0A0D9SG55
ENSG00000196628ENST00000628078A0A0D9SFU5
ENSG00000196628ENST00000628636A0A0D9SEK1
ENSG00000196628ENST00000628689A0A0D9SFZ1
ENSG00000196628ENST00000629343A0A0D9SEZ3
ENSG00000196628ENST00000629387P15884
ENSG00000196628ENST00000630224A0A0D9SG44
ENSG00000196628ENST00000630268A0A0D9SF97
ENSG00000196628ENST00000630319A0A0D9SF18
ENSG00000196628ENST00000630712A0A0D9SGE7
ENSG00000196628ENST00000630720A0A0D9SG78
ENSG00000196628ENST00000630828A0A0D9SFX5
ENSG00000196628ENST00000635822A0A1B0GVB8
ENSG00000196628ENST00000636400P15884
ENSG00000196628ENST00000636751A0A1B0GTP2
ENSG00000196628ENST00000636822A0A1B0GWD5
ENSG00000196628ENST00000637115A0A1B0GUT3
ENSG00000196628ENST00000637169A0A1B0GW91
ENSG00000196628ENST00000637923A0A1B0GV10
ENSG00000196628ENST00000638154A0A1B0GVR6
ENSG00000196628ENST00000643689A0A1B0GWD5

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
MyogenesisREACTOMER-HSA-525793
CDO in myogenesisREACTOMER-HSA-375170

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195718082009Common variants conferring risk of schizophrenia.575
188541532008Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development.227
208253142010E2-2 protein and Fuchs's corneal dystrophy.99
208253142010E2-2 protein and Fuchs's corneal dystrophy.99
217915502011Common variants at VRK2 and TCF4 conferring risk of schizophrenia.74
231852962012A common trinucleotide repeat expansion within the transcription factor 4 (TCF4, E2-2) gene predicts Fuchs corneal dystrophy.71
210372402011Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
187920172008Development of human plasmacytoid dendritic cells depends on the combined action of the basic helix-loop-helix factor E2-2 and the Ets factor Spi-B.54
174784762007Severe mental retardation with breathing abnormalities (Pitt-Hopkins syndrome) is caused by haploinsufficiency of the neuronal bHLH transcription factor TCF4.50

Citation

Dessen P

TCF4 (transcription factor 4)

Atlas Genet Cytogenet Oncol Haematol. 2004-05-01

Online version: http://atlasgeneticsoncology.org/gene/450/tcf4