TDGF1 (teratocarcinoma-derived growth factor 1)

2003-02-01  

Identity

HGNC
LOCATION
3p21.31
LOCUSID
ALIAS
CR,CR-1,CRGF,CRIPTO
FUSION GENES

Other Information

Locus ID:

NCBI: 6997
MIM: 187395
HGNC: 11701
Ensembl: ENSG00000241186

Variants:

dbSNP: 6997
ClinVar: 6997
TCGA: ENSG00000241186
COSMIC: TDGF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000241186ENST00000296145P13385
ENSG00000241186ENST00000542931F5H1T8

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Signaling by NODALREACTOMER-HSA-1181150
Regulation of signaling by NODALREACTOMER-HSA-1433617
Transcriptional regulation of pluripotent stem cellsREACTOMER-HSA-452723
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferationREACTOMER-HSA-2892247

References

Pubmed IDYearTitleCitations
120528552002Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway.64
194211462009Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
126823032003Cripto forms a complex with activin and type II activin receptors and can block activin signaling.51
145814552003Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells.49
249111462014CRIPTO1 expression in EGFR-mutant NSCLC elicits intrinsic EGFR-inhibitor resistance.38
225424932012Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer.36
170306172006Cripto binds transforming growth factor beta (TGF-beta) and inhibits TGF-beta signaling.33
177209762007Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration.31
169512342006Identification of cripto-1 as a novel serologic marker for breast and colon cancer.30

Citation

Dessen P

TDGF1 (teratocarcinoma-derived growth factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42507/tdgf1