TEK (TEK tyrosine kinase, endothelial)

Identity

Other names	CD202B
	TIE-2
	TIE2
	VMCM
	VMCM1
HGNC	TEK
Location	9p21
Location_base_pair	Starts at 27099147 and ends at 27220172 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	TEK   11724
Entrez_Gene	TEK  7010  TEK tyrosine kinase, endothelial
	Cards
GeneCards	TEK
Ensembl	TEK [Search_View]   ENSG00000120156 [Gene_View]
Genatlas	TEK
GeneLynx	TEK
eGenome	TEK
euGene	7010
	Genomic and cartography
GoldenPath	TEK  -  9p21   chr9:27099147-27220172 +  9p21.2   [Description]    (hg18-March_2006)
Ensembl	TEK - 9p21.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TEK
	Gene and transcription
Genbank	AB086825 [ ENTREZ ]
Genbank	AB208796 [ ENTREZ ]
Genbank	AK291775 [ ENTREZ ]
Genbank	AK308447 [ ENTREZ ]
Genbank	AW020953 [ ENTREZ ]
RefSeq	NM_000459 [ SRS ]    NM_000459 [ ENTREZ ]
RefSeq	AC_000052 [ SRS ]    AC_000052 [ ENTREZ ]
RefSeq	AC_000141 [ SRS ]    AC_000141 [ ENTREZ ]
RefSeq	NC_000009 [ SRS ]    NC_000009 [ ENTREZ ]
RefSeq	NT_008413 [ SRS ]    NT_008413 [ ENTREZ ]
RefSeq	NW_001839149 [ SRS ]    NW_001839149 [ ENTREZ ]
RefSeq	NW_924062 [ SRS ]    NW_924062 [ ENTREZ ]
AceView	TEK AceView - NCBI
Unigene	Hs.89640 [ SRS ]    Hs.89640 [ NCBI ]     HS89640 [ spliceNest ]
Fast-db	3713 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q02763 [ SRS]    Q02763 [ EXPASY ]     Q02763 [ INTERPRO ]     Q02763 [ UNIPROT ]
Prosite	PS00022 EGF_1 [ SRS ]    PS00022 EGF_1 [ Expasy ]
Prosite	PS01186 EGF_2 [ SRS ]    PS01186 EGF_2 [ Expasy ]
Prosite	PS50026 EGF_3 [ SRS ]    PS50026 EGF_3 [ Expasy ]
Prosite	PS50853 FN3 [ SRS ]    PS50853 FN3 [ Expasy ]
Prosite	PS50835 IG_LIKE [ SRS ]    PS50835 IG_LIKE [ Expasy ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00109 PROTEIN_KINASE_TYR [ SRS ]    PS00109 PROTEIN_KINASE_TYR [ Expasy ]
Interpro	IPR006210 EGF [ SRS ]    IPR006210 EGF [ EBI ]
Interpro	IPR000742 EGF_3 [ SRS ]    IPR000742 EGF_3 [ EBI ]
Interpro	IPR013111 EGF_extracell [ SRS ]    IPR013111 EGF_extracell [ EBI ]
Interpro	IPR013032 EGF_like_reg_CS [ SRS ]    IPR013032 EGF_like_reg_CS [ EBI ]
Interpro	IPR008957 Fibronectin_typ-III-like_fold [ SRS ]    IPR008957 Fibronectin_typ-III-like_fold [ EBI ]
Interpro	IPR003961 FN_III [ SRS ]    IPR003961 FN_III [ EBI ]
Interpro	IPR007110 Ig-like [ SRS ]    IPR007110 Ig-like [ EBI ]
Interpro	IPR013783 Ig-like_fold [ SRS ]    IPR013783 Ig-like_fold [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR015781 TieRTK [ SRS ]    IPR015781 TieRTK [ EBI ]
Interpro	IPR001245 Tyr_pkinase [ SRS ]    IPR001245 Tyr_pkinase [ EBI ]
Interpro	IPR008266 Tyr_pkinase_AS [ SRS ]    IPR008266 Tyr_pkinase_AS [ EBI ]
CluSTr	Q02763
Pfam	PF07974 EGF_2 [ SRS ]    PF07974 EGF_2 [ Sanger ]    pfam07974 [ NCBI-CDD ]
Pfam	PF00041 fn3 [ SRS ]    PF00041 fn3 [ Sanger ]    pfam00041 [ NCBI-CDD ]
Pfam	PF07714 Pkinase_Tyr [ SRS ]    PF07714 Pkinase_Tyr [ Sanger ]    pfam07714 [ NCBI-CDD ]
Smart	SM00181 EGF [EMBL]
Smart	SM00060 FN3 [EMBL]
Smart	SM00219 TyrKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	Q02763 TIE2_HUMAN [ Domain structure ]   Q02763 TIE2_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	Q02763
PDB	1FVR [ SRS ]    1FVR [ PdbSum ],   1FVR [ IMB ]   1FVR [ RSDB ]
PDB	2GY5 [ SRS ]    2GY5 [ PdbSum ],   2GY5 [ IMB ]   2GY5 [ RSDB ]
PDB	2GY7 [ SRS ]    2GY7 [ PdbSum ],   2GY7 [ IMB ]   2GY7 [ RSDB ]
PDB	2OO8 [ SRS ]    2OO8 [ PdbSum ],   2OO8 [ IMB ]   2OO8 [ RSDB ]
PDB	2OSC [ SRS ]    2OSC [ PdbSum ],   2OSC [ IMB ]   2OSC [ RSDB ]
PDB	2P4I [ SRS ]    2P4I [ PdbSum ],   2P4I [ IMB ]   2P4I [ RSDB ]
HPRD	02571
	Protein Interaction databases
DIP	Q02763
IntAct	Q02763
	Polymorphism : SNP, mutations, diseases
OMIM	600195;600221    [ map ]
GENECLINICS	600195;600221
SNP	TEK [dbSNP-NCBI]
SNP	NM_000459 [SNP-NCI]
SNP	TEK [GeneSNPs - Utah]  TEK] [HGBASE - SRS]
HAPMAP	TEK [HAPMAP]
COSMIC	TEK [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	TEK
	General knowledge
Family Browser	TEK [UCSC Family Browser]
SOURCE	NM_000459
SMD	Hs.89640
SAGE	Hs.89640
Enzyme	2.7.10.1 [ Enzyme-Expasy ]   2.7.10.1 [ Enzyme-SRS ]   2.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   2.7.10.1 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	protein tyrosine kinase activity [Amigo]  protein tyrosine kinase activity
GO	transmembrane receptor protein tyrosine kinase activity [Amigo]  transmembrane receptor protein tyrosine kinase activity
GO	receptor activity [Amigo]  receptor activity
GO	receptor activity [Amigo]  receptor activity
GO	ATP binding [Amigo]  ATP binding
GO	plasma membrane [Amigo]  plasma membrane
GO	integral to plasma membrane [Amigo]  integral to plasma membrane
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	signal transduction [Amigo]  signal transduction
GO	transmembrane receptor protein tyrosine kinase signaling pathway [Amigo]  transmembrane receptor protein tyrosine kinase signaling pathway
GO	cell-cell signaling [Amigo]  cell-cell signaling
GO	kinase activity [Amigo]  kinase activity
GO	transferase activity [Amigo]  transferase activity
PubGene	TEK
TreeFam	TEK
CTD	7010 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TEK Related clones (RZPD - Berlin)
	PubMed
PubMed	92 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 15:04:17 2008