TGFB2 (transforming growth factor beta 2)

2003-02-01 Affiliation

Identity

HGNC

TGFB2

LOCATION

1q41

LOCUSID

7042

ALIAS

G-TSF,LDS4,TGF-beta2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7042
MIM: 190220
HGNC: 11768
Ensembl: ENSG00000092969

Variants:

dbSNP: 7042
ClinVar: 7042
TCGA: ENSG00000092969
COSMIC: TGFB2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000092969	ENST00000366929	P61812
ENSG00000092969	ENST00000366930	P61812

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Cytokine-cytokine receptor interaction	KEGG	ko04060
Cell cycle	KEGG	ko04110
TGF-beta signaling pathway	KEGG	ko04350
Colorectal cancer	KEGG	ko05210
Renal cell carcinoma	KEGG	ko05211
Pancreatic cancer	KEGG	ko05212
Chronic myeloid leukemia	KEGG	ko05220
MAPK signaling pathway	KEGG	hsa04010
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Cell cycle	KEGG	hsa04110
TGF-beta signaling pathway	KEGG	hsa04350
Pathways in cancer	KEGG	hsa05200
Colorectal cancer	KEGG	hsa05210
Renal cell carcinoma	KEGG	hsa05211
Pancreatic cancer	KEGG	hsa05212
Chronic myeloid leukemia	KEGG	hsa05220
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Hypertrophic cardiomyopathy (HCM)	KEGG	ko05410
Hypertrophic cardiomyopathy (HCM)	KEGG	hsa05410
Dilated cardiomyopathy	KEGG	ko05414
Dilated cardiomyopathy	KEGG	hsa05414
Leishmaniasis	KEGG	ko05140
Leishmaniasis	KEGG	hsa05140
Chagas disease (American trypanosomiasis)	KEGG	ko05142
Chagas disease (American trypanosomiasis)	KEGG	hsa05142
Malaria	KEGG	ko05144
Malaria	KEGG	hsa05144
Amoebiasis	KEGG	ko05146
Amoebiasis	KEGG	hsa05146
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
Rheumatoid arthritis	KEGG	ko05323
Rheumatoid arthritis	KEGG	hsa05323
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Hepatitis B	KEGG	hsa05161
Hippo signaling pathway	KEGG	hsa04390
Hippo signaling pathway	KEGG	ko04390
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
Inflammatory bowel disease (IBD)	KEGG	hsa05321
Inflammatory bowel disease (IBD)	KEGG	ko05321
MicroRNAs in cancer	KEGG	hsa05206
MicroRNAs in cancer	KEGG	ko05206
FoxO signaling pathway	KEGG	hsa04068
TGF-beta signaling	KEGG	hsa_M00680
TGF-beta signaling	KEGG	M00680
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Response to elevated platelet cytosolic Ca2+	REACTOME	R-HSA-76005
Platelet degranulation	REACTOME	R-HSA-114608
Extracellular matrix organization	REACTOME	R-HSA-1474244
Elastic fibre formation	REACTOME	R-HSA-1566948
Molecules associated with elastic fibres	REACTOME	R-HSA-2129379
ECM proteoglycans	REACTOME	R-HSA-3000178
AGE-RAGE signaling pathway in diabetic complications	KEGG	ko04933
AGE-RAGE signaling pathway in diabetic complications	KEGG	hsa04933

References

Pubmed ID	Year	Title	Citations
22772368	2012	Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm.	124
22772371	2012	TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome.	114
17703412	2007	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	100
21585337	2011	Transforming growth factor-β2 promotes Snail-mediated endothelial-mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling.	97
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19965872	2010	Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction.	80
20875417	2011	TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine.	77
16260601	2005	Kinetic analysis of Smad nucleocytoplasmic shuttling reveals a mechanism for transforming growth factor beta-dependent nuclear accumulation of Smads.	76
11716069	2001	Glioma cell invasion: regulation of metalloproteinase activity by TGF-beta.	70
22739237	2013	IL-1β and TGFβ2 synergistically induce endothelial to mesenchymal transition in an NFκB-dependent manner.	51

Citation

Dessen P

TGFB2 (transforming growth factor beta 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42537/tgfb2