TGFBR2 (transforming growth factor, beta receptor II (70/80kDa))

Identity

Other names	AAT3
	FAA3
	LDS1B
	LDS2B
	MFS2
	RIIC
	TAAD2
	TGFR-2
	TGFbeta-RII
HGNC	TGFBR2
Location	3p22
Location_base_pair	Starts at 30622998 and ends at 30710637 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	TGFBR2   11773
Entrez_Gene	TGFBR2  7048  transforming growth factor, beta receptor II (70/80kDa)
	Cards
GeneCards	TGFBR2
Ensembl	TGFBR2 [Search_View]   ENSG00000163513 [Gene_View]
Genatlas	TGFBR2
GeneLynx	TGFBR2
eGenome	TGFBR2
euGene	7048
	Genomic and cartography
GoldenPath	TGFBR2  -  3p22   chr3:30622998-30710637 +  3p24.1   [Description]    (hg18-March_2006)
Ensembl	TGFBR2 - 3p24.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TGFBR2
	Gene and transcription
Genbank	AI279872 [ ENTREZ ]
Genbank	AJ786388 [ ENTREZ ]
Genbank	AK300383 [ ENTREZ ]
Genbank	AK314102 [ ENTREZ ]
Genbank	AL554950 [ ENTREZ ]
RefSeq	NM_001024847 [ SRS ]    NM_001024847 [ ENTREZ ]
RefSeq	NM_003242 [ SRS ]    NM_003242 [ ENTREZ ]
RefSeq	AC_000046 [ SRS ]    AC_000046 [ ENTREZ ]
RefSeq	AC_000135 [ SRS ]    AC_000135 [ ENTREZ ]
RefSeq	NC_000003 [ SRS ]    NC_000003 [ ENTREZ ]
RefSeq	NG_007490 [ SRS ]    NG_007490 [ ENTREZ ]
RefSeq	NT_022517 [ SRS ]    NT_022517 [ ENTREZ ]
RefSeq	NW_001838877 [ SRS ]    NW_001838877 [ ENTREZ ]
RefSeq	NW_921651 [ SRS ]    NW_921651 [ ENTREZ ]
AceView	TGFBR2 AceView - NCBI
Unigene	Hs.604277 [ SRS ]    Hs.604277 [ NCBI ]     HS604277 [ spliceNest ]
Fast-db	3365 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P37173 [ SRS]    P37173 [ EXPASY ]     P37173 [ INTERPRO ]     P37173 [ UNIPROT ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Interpro	IPR000333 Activin_II_recpt [ SRS ]    IPR000333 Activin_II_recpt [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
Interpro	IPR015769 TGF-beta_II_C [ SRS ]    IPR015769 TGF-beta_II_C [ EBI ]
Interpro	IPR015013 TGF_beta_receptor2 [ SRS ]    IPR015013 TGF_beta_receptor2 [ EBI ]
Interpro	IPR017194 TGFRII [ SRS ]    IPR017194 TGFRII [ EBI ]
CluSTr	P37173
Pfam	PF08917 ecTbetaR2 [ SRS ]    PF08917 ecTbetaR2 [ Sanger ]    pfam08917 [ NCBI-CDD ]
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	P37173 TGFR2_HUMAN [ Domain structure ]   P37173 TGFR2_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P37173
PDB	1KTZ [ SRS ]    1KTZ [ PdbSum ],   1KTZ [ IMB ]   1KTZ [ RSDB ]
PDB	1M9Z [ SRS ]    1M9Z [ PdbSum ],   1M9Z [ IMB ]   1M9Z [ RSDB ]
PDB	1PLO [ SRS ]    1PLO [ PdbSum ],   1PLO [ IMB ]   1PLO [ RSDB ]
HPRD	01823
	Protein Interaction databases
DIP	P37173
IntAct	P37173
	Polymorphism : SNP, mutations, diseases
OMIM	133239;190182;610168;610380    [ map ]
GENECLINICS	133239;190182;610168;610380
SNP	TGFBR2 [dbSNP-NCBI]
SNP	NM_001024847 [SNP-NCI]
SNP	NM_003242 [SNP-NCI]
SNP	TGFBR2 [GeneSNPs - Utah]  TGFBR2] [HGBASE - SRS]
HAPMAP	TGFBR2 [HAPMAP]
COSMIC	TGFBR2 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	TGFBR2
	General knowledge
Family Browser	TGFBR2 [UCSC Family Browser]
SOURCE	NM_001024847
SOURCE	NM_003242
SMD	Hs.604277
SAGE	Hs.604277
Enzyme	2.7.11.30 [ Enzyme-Expasy ]   2.7.11.30 [ Enzyme-SRS ]   2.7.11.30 [ IntEnz-EBI ]   2.7.11.30 [ BRENDA ]   2.7.11.30 [ KEGG ]   2.7.11.30 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	magnesium ion binding [Amigo]  magnesium ion binding
GO	receptor activity [Amigo]  receptor activity
GO	transforming growth factor beta receptor activity, type II [Amigo]  transforming growth factor beta receptor activity, type II
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	plasma membrane [Amigo]  plasma membrane
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	transmembrane receptor protein serine/threonine kinase signaling pathway [Amigo]  transmembrane receptor protein serine/threonine kinase signaling pathway
GO	positive regulation of cell proliferation [Amigo]  positive regulation of cell proliferation
GO	integral to membrane [Amigo]  integral to membrane
GO	transferase activity [Amigo]  transferase activity
GO	manganese ion binding [Amigo]  manganese ion binding
GO	receptor complex [Amigo]  receptor complex
BIOCARTA	ALK in cardiac myocytes    [Genes]
BIOCARTA	NFkB activation by Nontypeable Hemophilus influenzae    [Genes]
BIOCARTA	TGF beta signaling pathway    [Genes]
KEGG	MAPK signaling pathway
KEGG	Cytokine-cytokine receptor interaction
KEGG	TGF-beta signaling pathway
KEGG	Adherens junction
KEGG	Colorectal cancer
PubGene	TGFBR2
TreeFam	TGFBR2
CTD	7048 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TGFBR2 Related clones (RZPD - Berlin)
	PubMed
PubMed	164 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 15:04:28 2008