TIMELESS (timeless circadian regulator)

2007-12-01  

Identity

HGNC
LOCATION
12q13.3
LOCUSID
ALIAS
TIM,TIM1,hTIM
FUSION GENES

Other Information

Locus ID:

NCBI: 8914
MIM: 603887
HGNC: 11813
Ensembl: ENSG00000111602

Variants:

dbSNP: 8914
ClinVar: 8914
TCGA: ENSG00000111602
COSMIC: TIMELESS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111602ENST00000229201Q9UNS1
ENSG00000111602ENST00000553532Q9UNS1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
172967252007The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement.124
157981972005Coupling of human circadian and cell cycles by the timeless protein.113
200721162010Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.91
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
171168852006Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function.82
165070062006Association study of eight circadian genes with bipolar I disorder, schizoaffective disorder and schizophrenia.72
171418022007Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors.71
171021372007Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint.68
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
182285282008Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm.60

Citation

Dessen P

TIMELESS (timeless circadian regulator)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49895/timeless