TK1 (thymidine kinase 1)

2003-05-01 Affiliation

Identity

HGNC

TK1

LOCATION

17q25.3

LOCUSID

7083

ALIAS

TK2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7083
MIM: 188300
HGNC: 11830
Ensembl: ENSG00000167900

Variants:

dbSNP: 7083
ClinVar: 7083
TCGA: ENSG00000167900
COSMIC: TK1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000167900	ENST00000301634	P04183
ENSG00000167900	ENST00000301634	A0A384MDV9
ENSG00000167900	ENST00000586613	K7ERJ1
ENSG00000167900	ENST00000588734	K7ERV3
ENSG00000167900	ENST00000590430	K7ENW5
ENSG00000167900	ENST00000590862	K7ES52

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Pyrimidine metabolism	KEGG	ko00240
Drug metabolism - other enzymes	KEGG	ko00983
Pyrimidine metabolism	KEGG	hsa00240
Drug metabolism - other enzymes	KEGG	hsa00983
Metabolic pathways	KEGG	hsa01100
Metabolism	REACTOME	R-HSA-1430728
Metabolism of nucleotides	REACTOME	R-HSA-15869
Pyrimidine metabolism	REACTOME	R-HSA-73848
Pyrimidine salvage reactions	REACTOME	R-HSA-73614

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA128406956	fluorouracil	Chemical	VariantAnnotation	not associated	PD
PA445058	Neoplasm Metastasis	Disease	VariantAnnotation	not associated	PD
PA448771	capecitabine	Chemical	VariantAnnotation	not associated	PD
PA451954	zidovudine	Chemical	Pathway	associated		22960662

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
15611477	2004	Structures of thymidine kinase 1 of human and mycoplasmic origin.	34
14701726	2004	Mitotic degradation of human thymidine kinase 1 is dependent on the anaphase-promoting complex/cyclosome-CDH1-mediated pathway.	33
21505426	2011	Combined Flt3L/TK gene therapy induces immunological surveillance which mediates an immune response against a surrogate brain tumor neoantigen.	29
20554529	2010	Regulation and functional contribution of thymidine kinase 1 in repair of DNA damage.	27
20544519	2010	Thymidine kinase 1 is a potential marker for prognosis and monitoring the response to treatment of patients with breast, lung, and esophageal cancer and non-Hodgkin's lymphoma.	18
21764789	2011	Tumor 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) uptake by PET correlates with thymidine kinase 1 expression: static and kinetic analysis of (18)F-FLT PET studies in lung tumors.	18
17407781	2007	Binding of ATP to TK1-like enzymes is associated with a conformational change in the quaternary structure.	16
29247745	2018	Thymidine kinase 1 combined with CEA, CYFRA21-1 and NSE improved its diagnostic value for lung cancer.	14
15733844	2005	Structure of a type II thymidine kinase with bound dTTP.	13

Citation

Dessen P

TK1 (thymidine kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42576/tk1