TLE1 (TLE family member 1, transcriptional corepressor)

2007-03-01  

Identity

HGNC
LOCATION
9q21.32
LOCUSID
ALIAS
ESG,ESG1,GRG1
FUSION GENES

Other Information

Locus ID:

NCBI: 7088
MIM: 600189
HGNC: 11837
Ensembl: ENSG00000196781

Variants:

dbSNP: 7088
ClinVar: 7088
TCGA: ENSG00000196781
COSMIC: TLE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196781ENST00000376463Q5T3G2
ENSG00000196781ENST00000376484F6T2C8
ENSG00000196781ENST00000376499Q04724
ENSG00000196781ENST00000418319Q5T3G3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
NOTCH1 Intracellular Domain Regulates TranscriptionREACTOMER-HSA-2122947
Signaling by WntREACTOMER-HSA-195721
Degradation of beta-catenin by the destruction complexREACTOMER-HSA-195253
Repression of WNT target genesREACTOMER-HSA-4641265
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Formation of the beta-catenin:TCF transactivating complexREACTOMER-HSA-201722
Deactivation of the beta-catenin transactivating complexREACTOMER-HSA-3769402

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
157680322005Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation.205
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
172557692007TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies.61
245962492014Molecular functions of the TLE tetramerization domain in Wnt target gene repression.36
182587962008Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival.35
176807802007Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription.30
193634722009TLE1 expression is not specific for synovial sarcoma: a whole section study of 163 soft tissue and bone neoplasms.28
120571912002Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor.25
201600712010Transcriptional corepressor TLE1 functions with Runx2 in epigenetic repression of ribosomal RNA genes.24
185196702008Epigenetic inactivation of the Groucho homologue gene TLE1 in hematologic malignancies.23

Citation

Dessen P

TLE1 (TLE family member 1, transcriptional corepressor)

Atlas Genet Cytogenet Oncol Haematol. 2007-03-01

Online version: http://atlasgeneticsoncology.org/gene/46607/tle1