TLR8 (toll-like receptor 8)

Identity

Other names	CD288
	MGC119599
	MGC119600
HGNC	TLR8
Location	Xp22
Location_base_pair	Starts at 12834679 and ends at 12851209 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	TLR8   15632
Entrez_Gene	TLR8  51311  toll-like receptor 8
	Cards
GeneCards	TLR8
Ensembl	TLR8 [Search_View]   ENSG00000101916 [Gene_View]
Genatlas	TLR8
GeneLynx	TLR8
eGenome	TLR8
euGene	51311
	Genomic and cartography
GoldenPath	TLR8  -  Xp22   chrX:12834679-12851209 +  Xp22.2   [Description]    (hg18-March_2006)
Ensembl	TLR8 - Xp22.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TLR8
	Gene and transcription
Genbank	AB445666 [ ENTREZ ]
Genbank	AF245703 [ ENTREZ ]
Genbank	AF246971 [ ENTREZ ]
Genbank	AK075117 [ ENTREZ ]
Genbank	AY358296 [ ENTREZ ]
RefSeq	NM_138636 [ SRS ]    NM_138636 [ ENTREZ ]
RefSeq	AC_000066 [ SRS ]    AC_000066 [ ENTREZ ]
RefSeq	AC_000155 [ SRS ]    AC_000155 [ ENTREZ ]
RefSeq	NC_000023 [ SRS ]    NC_000023 [ ENTREZ ]
RefSeq	NT_011757 [ SRS ]    NT_011757 [ ENTREZ ]
RefSeq	NW_001842360 [ SRS ]    NW_001842360 [ ENTREZ ]
RefSeq	NW_927700 [ SRS ]    NW_927700 [ ENTREZ ]
AceView	TLR8 AceView - NCBI
Unigene	Hs.660543 [ SRS ]    Hs.660543 [ NCBI ]     HS660543 [ spliceNest ]
Fast-db	1909 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q495P6 [ SRS]    Q495P6 [ EXPASY ]     Q495P6 [ INTERPRO ]     Q495P6 [ UNIPROT ]
Prosite	PS50104 TIR [ SRS ]    PS50104 TIR [ Expasy ]
Interpro	IPR004075 IL1_rcpt_1 [ SRS ]    IPR004075 IL1_rcpt_1 [ EBI ]
Interpro	IPR001611 LRR [ SRS ]    IPR001611 LRR [ EBI ]
Interpro	IPR000483 LRR_C [ SRS ]    IPR000483 LRR_C [ EBI ]
Interpro	IPR003591 LRR_sub-typ [ SRS ]    IPR003591 LRR_sub-typ [ EBI ]
Interpro	IPR015764 LRR_Toll-like_rcpt8 [ SRS ]    IPR015764 LRR_Toll-like_rcpt8 [ EBI ]
Interpro	IPR000157 TIR [ SRS ]    IPR000157 TIR [ EBI ]
CluSTr	Q495P6
Pfam	PF00560 LRR_1 [ SRS ]    PF00560 LRR_1 [ Sanger ]    pfam00560 [ NCBI-CDD ]
Pfam	PF01582 TIR [ SRS ]    PF01582 TIR [ Sanger ]    pfam01582 [ NCBI-CDD ]
Smart	SM00369 LRR_TYP [EMBL]
Smart	SM00082 LRRCT [EMBL]
Blocks	Q495P6
HPRD	02296
	Protein Interaction databases
DIP	Q495P6
IntAct	Q495P6
	Polymorphism : SNP, mutations, diseases
OMIM	300366    [ map ]
GENECLINICS	300366
SNP	TLR8 [dbSNP-NCBI]
SNP	NM_138636 [SNP-NCI]
SNP	TLR8 [GeneSNPs - Utah]  TLR8] [HGBASE - SRS]
HAPMAP	TLR8 [HAPMAP]
COSMIC	TLR8 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	TLR8
	General knowledge
Family Browser	TLR8 [UCSC Family Browser]
SOURCE	NM_138636
SMD	Hs.660543
SAGE	Hs.660543
GO	DNA binding [Amigo]  DNA binding
GO	double-stranded RNA binding [Amigo]  double-stranded RNA binding
GO	single-stranded RNA binding [Amigo]  single-stranded RNA binding
GO	transmembrane receptor activity [Amigo]  transmembrane receptor activity
GO	Toll binding [Amigo]  Toll binding
GO	protein binding [Amigo]  protein binding
GO	inflammatory response [Amigo]  inflammatory response
GO	signal transduction [Amigo]  signal transduction
GO	I-kappaB kinase/NF-kappaB cascade [Amigo]  I-kappaB kinase/NF-kappaB cascade
GO	I-kappaB kinase/NF-kappaB cascade [Amigo]  I-kappaB kinase/NF-kappaB cascade
GO	detection of virus [Amigo]  detection of virus
GO	endosome membrane [Amigo]  endosome membrane
GO	membrane [Amigo]  membrane
GO	integral to membrane [Amigo]  integral to membrane
GO	immunoglobulin mediated immune response [Amigo]  immunoglobulin mediated immune response
GO	intrinsic to membrane [Amigo]  intrinsic to membrane
GO	positive regulation of interferon-gamma biosynthetic process [Amigo]  positive regulation of interferon-gamma biosynthetic process
GO	innate immune response [Amigo]  innate immune response
GO	positive regulation of innate immune response [Amigo]  positive regulation of innate immune response
GO	positive regulation of interferon-alpha biosynthetic process [Amigo]  positive regulation of interferon-alpha biosynthetic process
GO	positive regulation of interferon-beta biosynthetic process [Amigo]  positive regulation of interferon-beta biosynthetic process
GO	positive regulation of interleukin-8 biosynthetic process [Amigo]  positive regulation of interleukin-8 biosynthetic process
GO	defense response to virus [Amigo]  defense response to virus
PubGene	TLR8
TreeFam	TLR8
CTD	51311 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TLR8 Related clones (RZPD - Berlin)
	PubMed
PubMed	38 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 15:04:51 2008