TLX1 (T-cell leukemia homeobox 1)

Identity

Other names	HOX11
	MGC163402
	TCL3
HGNC	TLX1
Location	10q24.32
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	TLX1   5056
Entrez_Gene	TLX1  3195  T-cell leukemia homeobox 1
	Cards
GeneCards	TLX1
Ensembl	TLX1 [Search_View]   ENSG00000107807 [Gene_View]
Genatlas	TLX1
GeneLynx	TLX1
eGenome	TLX1
euGene	3195
	Genomic and cartography
GoldenPath	TLX1  -  10q24.32   chr10:102880252-102887526 +  10q24.31   [Description]    (hg18-March_2006)
Ensembl	TLX1 - 10q24.31 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TLX1
	Gene and transcription
Genbank	BC130530 [ ENTREZ ]
Genbank	M62626 [ ENTREZ ]
Genbank	M75952 [ ENTREZ ]
Genbank	S38742 [ ENTREZ ]
RefSeq	NM_005521 [ SRS ]    NM_005521 [ ENTREZ ]
RefSeq	AC_000053 [ SRS ]    AC_000053 [ ENTREZ ]
RefSeq	AC_000142 [ SRS ]    AC_000142 [ ENTREZ ]
RefSeq	NC_000010 [ SRS ]    NC_000010 [ ENTREZ ]
RefSeq	NT_030059 [ SRS ]    NT_030059 [ ENTREZ ]
RefSeq	NW_001838006 [ SRS ]    NW_001838006 [ ENTREZ ]
RefSeq	NW_924884 [ SRS ]    NW_924884 [ ENTREZ ]
AceView	TLX1 AceView - NCBI
Unigene	Hs.89583 [ SRS ]    Hs.89583 [ NCBI ]     HS89583 [ spliceNest ]
Fast-db	16462 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P31314 [ SRS]    P31314 [ EXPASY ]     P31314 [ INTERPRO ]     P31314 [ UNIPROT ]
Prosite	PS00027 HOMEOBOX_1 [ SRS ]    PS00027 HOMEOBOX_1 [ Expasy ]
Prosite	PS50071 HOMEOBOX_2 [ SRS ]    PS50071 HOMEOBOX_2 [ Expasy ]
Interpro	IPR000747 Engrailed [ SRS ]    IPR000747 Engrailed [ EBI ]
Interpro	IPR001356 Homeobox [ SRS ]    IPR001356 Homeobox [ EBI ]
Interpro	IPR012287 Homeodomain-rel [ SRS ]    IPR012287 Homeodomain-rel [ EBI ]
CluSTr	P31314
Pfam	PF00046 Homeobox [ SRS ]    PF00046 Homeobox [ Sanger ]    pfam00046 [ NCBI-CDD ]
Smart	SM00389 HOX [EMBL]
Prodom	PD000010 Homeobox[INRA-Toulouse]
Prodom	P31314 TLX1_HUMAN [ Domain structure ]   P31314 TLX1_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P31314
HPRD	01728
	Protein Interaction databases
DIP	P31314
IntAct	P31314
	Polymorphism : SNP, mutations, diseases
OMIM	186770    [ map ]
GENECLINICS	186770
SNP	TLX1 [dbSNP-NCBI]
SNP	NM_005521 [SNP-NCI]
SNP	TLX1 [GeneSNPs - Utah]  TLX1] [HGBASE - SRS]
HAPMAP	TLX1 [HAPMAP]
COSMIC	TLX1 [Somatic mutation (COSMIC-CGP-Sanger)]
TICdb	transcription [Translocation breakpoints In Cancer]
HGMD	TLX1
	General knowledge
Family Browser	TLX1 [UCSC Family Browser]
SOURCE	NM_005521
SMD	Hs.89583
SAGE	Hs.89583
GO	transcription factor activity [Amigo]  transcription factor activity
GO	nucleus [Amigo]  nucleus
GO	regulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
GO	multicellular organismal development [Amigo]  multicellular organismal development
GO	central nervous system development [Amigo]  central nervous system development
GO	positive regulation of cell proliferation [Amigo]  positive regulation of cell proliferation
GO	neuron differentiation [Amigo]  neuron differentiation
GO	sequence-specific DNA binding [Amigo]  sequence-specific DNA binding
GO	cell fate commitment [Amigo]  cell fate commitment
GO	positive regulation of transcription from RNA polymerase II promoter [Amigo]  positive regulation of transcription from RNA polymerase II promoter
GO	protein heterodimerization activity [Amigo]  protein heterodimerization activity
GO	spleen development [Amigo]  spleen development
GO	organ formation [Amigo]  organ formation
PubGene	TLX1
TreeFam	TLX1
CTD	3195 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TLX1 Related clones (RZPD - Berlin)
	PubMed
PubMed	28 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:35:18 2008