TNFRSF10A (tumor necrosis factor receptor superfamily, member 10a)

Identity

Other names	APO2
	CD261
	DR4
	MGC9365
	TRAILR-1
	TRAILR1
HGNC	TNFRSF10A
Location	8p21
Location_base_pair	Starts at 23104915 and ends at 23138584 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	TNFRSF10A   11904
Entrez_Gene	TNFRSF10A  8797  tumor necrosis factor receptor superfamily, member 10a
	Cards
GeneCards	TNFRSF10A
Ensembl	TNFRSF10A [Search_View]   ENSG00000104689 [Gene_View]
Genatlas	TNFRSF10A
GeneLynx	TNFRSF10A
eGenome	TNFRSF10A
euGene	8797
	Genomic and cartography
GoldenPath	TNFRSF10A  -  8p21   chr8:23104915-23138584 -  8p21.3   [Description]    (hg18-March_2006)
Ensembl	TNFRSF10A - 8p21.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TNFRSF10A
	Gene and transcription
Genbank	AK291299 [ ENTREZ ]
Genbank	BC012866 [ ENTREZ ]
Genbank	BT006906 [ ENTREZ ]
Genbank	DQ891791 [ ENTREZ ]
Genbank	DQ894973 [ ENTREZ ]
RefSeq	NM_003844 [ SRS ]    NM_003844 [ ENTREZ ]
RefSeq	AC_000051 [ SRS ]    AC_000051 [ ENTREZ ]
RefSeq	AC_000140 [ SRS ]    AC_000140 [ ENTREZ ]
RefSeq	NC_000008 [ SRS ]    NC_000008 [ ENTREZ ]
RefSeq	NT_023666 [ SRS ]    NT_023666 [ ENTREZ ]
RefSeq	NW_001839127 [ SRS ]    NW_001839127 [ ENTREZ ]
RefSeq	NW_923907 [ SRS ]    NW_923907 [ ENTREZ ]
AceView	TNFRSF10A AceView - NCBI
Unigene	Hs.591834 [ SRS ]    Hs.591834 [ NCBI ]     HS591834 [ spliceNest ]
Fast-db	2638 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O00220 [ SRS]    O00220 [ EXPASY ]     O00220 [ INTERPRO ]     O00220 [ UNIPROT ]
Prosite	PS50017 DEATH_DOMAIN [ SRS ]    PS50017 DEATH_DOMAIN [ Expasy ]
Prosite	PS00652 TNFR_NGFR_1 [ SRS ]    PS00652 TNFR_NGFR_1 [ Expasy ]
Prosite	PS50050 TNFR_NGFR_2 [ SRS ]    PS50050 TNFR_NGFR_2 [ Expasy ]
Interpro	IPR000488 Death [ SRS ]    IPR000488 Death [ EBI ]
Interpro	IPR011029 DEATH_like [ SRS ]    IPR011029 DEATH_like [ EBI ]
Interpro	IPR017301 TNF-rel_apoptosis-ind_lig_rcpt [ SRS ]    IPR017301 TNF-rel_apoptosis-ind_lig_rcpt [ EBI ]
Interpro	IPR001368 TNFR_c6 [ SRS ]    IPR001368 TNFR_c6 [ EBI ]
CluSTr	O00220
Pfam	PF00531 Death [ SRS ]    PF00531 Death [ Sanger ]    pfam00531 [ NCBI-CDD ]
Pfam	PF00020 TNFR_c6 [ SRS ]    PF00020 TNFR_c6 [ Sanger ]    pfam00020 [ NCBI-CDD ]
Smart	SM00005 DEATH [EMBL]
Smart	SM00208 TNFR [EMBL]
Blocks	O00220
HPRD	04679
	Protein Interaction databases
DIP	O00220
IntAct	O00220
	Polymorphism : SNP, mutations, diseases
OMIM	603611    [ map ]
GENECLINICS	603611
SNP	TNFRSF10A [dbSNP-NCBI]
SNP	NM_003844 [SNP-NCI]
SNP	TNFRSF10A [GeneSNPs - Utah]  TNFRSF10A] [HGBASE - SRS]
HAPMAP	TNFRSF10A [HAPMAP]
COSMIC	TNFRSF10A [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	TNFRSF10A
	General knowledge
Family Browser	TNFRSF10A [UCSC Family Browser]
SOURCE	NM_003844
SMD	Hs.591834
SAGE	Hs.591834
GO	receptor activity [Amigo]  receptor activity
GO	death receptor activity [Amigo]  death receptor activity
GO	apoptosis [Amigo]  apoptosis
GO	induction of apoptosis [Amigo]  induction of apoptosis
GO	caspase activation [Amigo]  caspase activation
GO	signal transduction [Amigo]  signal transduction
GO	activation of NF-kappaB-inducing kinase activity [Amigo]  activation of NF-kappaB-inducing kinase activity
GO	induction of apoptosis via death domain receptors [Amigo]  induction of apoptosis via death domain receptors
GO	caspase activator activity [Amigo]  caspase activator activity
GO	membrane [Amigo]  membrane
GO	integral to membrane [Amigo]  integral to membrane
GO	TRAIL binding [Amigo]  TRAIL binding
BIOCARTA	Induction of apoptosis through DR3 and DR4/5 Death Receptors    [Genes]
KEGG	Cytokine-cytokine receptor interaction
KEGG	Apoptosis
KEGG	Natural killer cell mediated cytotoxicity
PubGene	TNFRSF10A
TreeFam	TNFRSF10A
CTD	8797 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TNFRSF10A Related clones (RZPD - Berlin)
	PubMed
PubMed	75 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 15:05:08 2008