TNFRSF1B (TNF receptor superfamily member 1B)

2003-02-01 Affiliation

Identity

HGNC

TNFRSF1B

LOCATION

1p36.22

LOCUSID

7133

ALIAS

CD120b,TBPII,TNF-R-II,TNF-R75,TNFBR,TNFR1B,TNFR2,TNFR80,p75,p75TNFR

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7133
MIM: 191191
HGNC: 11917
Ensembl: ENSG00000028137

Variants:

dbSNP: 7133
ClinVar: 7133
TCGA: ENSG00000028137
COSMIC: TNFRSF1B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000028137	ENST00000376259	P20333
ENSG00000028137	ENST00000536782	B5A977

Expression (GTEx)

100

150

200

250

300

350

400

450

500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Adipocytokine signaling pathway	KEGG	ko04920
Amyotrophic lateral sclerosis (ALS)	KEGG	ko05014
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Adipocytokine signaling pathway	KEGG	hsa04920
Amyotrophic lateral sclerosis (ALS)	KEGG	hsa05014
TNF signaling pathway	KEGG	hsa04668
TNF signaling pathway	KEGG	ko04668
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
TNFR2 non-canonical NF-kB pathway	REACTOME	R-HSA-5668541
TNFs bind their physiological receptors	REACTOME	R-HSA-5669034
Neutrophil degranulation	REACTOME	R-HSA-6798695
Interleukin-4 and 13 signaling	REACTOME	R-HSA-6785807
Interleukin-10 signaling	REACTOME	R-HSA-6783783

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA164713366	Tumor necrosis factor alpha (TNF-alpha) inhibitors	Chemical	ClinicalAnnotation	associated	PD	18565259, 22129793, 25537528, 25850964
PA443434	Arthritis, Rheumatoid	Disease	ClinicalAnnotation	associated	PD	18565259, 22129793, 25537528, 25850964
PA445724	Spondylitis, Ankylosing	Disease	ClinicalAnnotation	associated	PD	30075559
PA449515	etanercept	Chemical	ClinicalAnnotation	associated	PD	30075559
PA452639	infliximab	Chemical	ClinicalAnnotation	associated	PD	18565259, 22129793, 25537528, 25850964

References

Pubmed ID	Year	Title	Citations
21393509	2011	The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.	221
14532286	2003	A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses.	153
11907583	2002	TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2.	143
17703412	2007	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	100
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
26258847	2015	Genomic analysis of mycosis fungoides and Sézary syndrome identifies recurrent alterations in TNFR2.	63
20181891	2010	TNF activates a NF-kappaB-regulated cellular program in human CD45RA- regulatory T cells that modulates their suppressive function.	58
16195372	2005	TNFR1- and TNFR2-mediated signaling pathways in human kidney are cell type-specific and differentially contribute to renal injury.	57
20038584	2010	Membrane tumor necrosis factor (TNF) induces p100 processing via TNF receptor-2 (TNFR2).	55
19174780	2009	Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort.	52

Citation

Dessen P

TNFRSF1B (TNF receptor superfamily member 1B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42621/tnfrsf1b