TNKS (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase)

Identity

Other names	PARP-5a
	PARP5A
	PARPL
	TIN1
	TINF1
	TNKS1
HGNC	TNKS
Location	8p23.1
Location_base_pair	Starts at 9450855 and ends at 9677266 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	TNKS   11941
Entrez_Gene	TNKS  8658  tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
	Cards
GeneCards	TNKS
Ensembl	TNKS [Search_View]   ENSG00000173273 [Gene_View]
Genatlas	TNKS
GeneLynx	TNKS
eGenome	TNKS
euGene	8658
	Genomic and cartography
GoldenPath	TNKS  -  8p23.1   chr8:9450855-9677266 +  8p23.1   [Description]    (hg18-March_2006)
Ensembl	TNKS - 8p23.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TNKS
	Gene and transcription
Genbank	AB209339 [ ENTREZ ]
Genbank	AF070613 [ ENTREZ ]
Genbank	AF082556 [ ENTREZ ]
Genbank	AF082557 [ ENTREZ ]
Genbank	AF082558 [ ENTREZ ]
RefSeq	NM_003747 [ SRS ]    NM_003747 [ ENTREZ ]
RefSeq	AC_000051 [ SRS ]    AC_000051 [ ENTREZ ]
RefSeq	AC_000140 [ SRS ]    AC_000140 [ ENTREZ ]
RefSeq	NC_000008 [ SRS ]    NC_000008 [ ENTREZ ]
RefSeq	NT_077531 [ SRS ]    NT_077531 [ ENTREZ ]
RefSeq	NW_001839122 [ SRS ]    NW_001839122 [ ENTREZ ]
RefSeq	NW_923873 [ SRS ]    NW_923873 [ ENTREZ ]
AceView	TNKS AceView - NCBI
Unigene	Hs.370267 [ SRS ]    Hs.370267 [ NCBI ]     HS370267 [ spliceNest ]
Fast-db	1195 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O95271 [ SRS]    O95271 [ EXPASY ]     O95271 [ INTERPRO ]     O95271 [ UNIPROT ]
Prosite	PS50297 ANK_REP_REGION [ SRS ]    PS50297 ANK_REP_REGION [ Expasy ]
Prosite	PS50088 ANK_REPEAT [ SRS ]    PS50088 ANK_REPEAT [ Expasy ]
Prosite	PS51059 PARP_CATALYTIC [ SRS ]    PS51059 PARP_CATALYTIC [ Expasy ]
Prosite	PS50105 SAM_DOMAIN [ SRS ]    PS50105 SAM_DOMAIN [ Expasy ]
Interpro	IPR002110 ANK [ SRS ]    IPR002110 ANK [ EBI ]
Interpro	IPR012317 PARP_catalytic [ SRS ]    IPR012317 PARP_catalytic [ EBI ]
Interpro	IPR001660 SAM [ SRS ]    IPR001660 SAM [ EBI ]
Interpro	IPR011510 SAM_2 [ SRS ]    IPR011510 SAM_2 [ EBI ]
Interpro	IPR013761 SAM_type [ SRS ]    IPR013761 SAM_type [ EBI ]
CluSTr	O95271
Pfam	PF00023 Ank [ SRS ]    PF00023 Ank [ Sanger ]    pfam00023 [ NCBI-CDD ]
Pfam	PF00644 PARP [ SRS ]    PF00644 PARP [ Sanger ]    pfam00644 [ NCBI-CDD ]
Pfam	PF07647 SAM_2 [ SRS ]    PF07647 SAM_2 [ Sanger ]    pfam07647 [ NCBI-CDD ]
Smart	SM00248 ANK [EMBL]
Smart	SM00454 SAM [EMBL]
Blocks	O95271
HPRD	04490
	Protein Interaction databases
DIP	O95271
IntAct	O95271
	Polymorphism : SNP, mutations, diseases
OMIM	603303    [ map ]
GENECLINICS	603303
SNP	TNKS [dbSNP-NCBI]
SNP	NM_003747 [SNP-NCI]
SNP	TNKS [GeneSNPs - Utah]  TNKS] [HGBASE - SRS]
HAPMAP	TNKS [HAPMAP]
COSMIC	TNKS [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	TNKS
	General knowledge
Family Browser	TNKS [UCSC Family Browser]
SOURCE	NM_003747
SMD	Hs.370267
SAGE	Hs.370267
Enzyme	2.4.2.30 [ Enzyme-Expasy ]   2.4.2.30 [ Enzyme-SRS ]   2.4.2.30 [ IntEnz-EBI ]   2.4.2.30 [ BRENDA ]   2.4.2.30 [ KEGG ]   2.4.2.30 [ WIT ]
GO	Golgi membrane [Amigo]  Golgi membrane
GO	chromosome, telomeric region [Amigo]  chromosome, telomeric region
GO	NAD+ ADP-ribosyltransferase activity [Amigo]  NAD+ ADP-ribosyltransferase activity
GO	protein binding [Amigo]  protein binding
GO	nucleus [Amigo]  nucleus
GO	nuclear pore [Amigo]  nuclear pore
GO	chromosome [Amigo]  chromosome
GO	cytoplasm [Amigo]  cytoplasm
GO	Golgi apparatus [Amigo]  Golgi apparatus
GO	telomere maintenance via telomerase [Amigo]  telomere maintenance via telomerase
GO	protein transport [Amigo]  protein transport
GO	membrane [Amigo]  membrane
GO	transferase activity, transferring glycosyl groups [Amigo]  transferase activity, transferring glycosyl groups
GO	peptidyl-serine phosphorylation [Amigo]  peptidyl-serine phosphorylation
GO	peptidyl-threonine phosphorylation [Amigo]  peptidyl-threonine phosphorylation
GO	mRNA transport [Amigo]  mRNA transport
GO	intracellular protein transport across a membrane [Amigo]  intracellular protein transport across a membrane
BIOCARTA	Telomeres, Telomerase, Cellular Aging, and Immortality    [Genes]
PubGene	TNKS
TreeFam	TNKS
CTD	8658 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TNKS Related clones (RZPD - Berlin)
	PubMed
PubMed	28 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 15:05:20 2008