TOP2B (topoisomerase (DNA) II beta 180kDa)

Identity

Other names	TOPIIB
	top2beta
HGNC	TOP2B
Location	3p24
Location_base_pair	Starts at 25614479 and ends at 25680792 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	TOP2B   11990
Entrez_Gene	TOP2B  7155  topoisomerase (DNA) II beta 180kDa
	Cards
GeneCards	TOP2B
Ensembl	TOP2B [Search_View]   ENSG00000077097 [Gene_View]
Genatlas	TOP2B
GeneLynx	TOP2B
eGenome	TOP2B
euGene	7155
	Genomic and cartography
GoldenPath	TOP2B  -  3p24   chr3:25614479-25680792 -  3p24.2   [Description]    (hg18-March_2006)
Ensembl	TOP2B - 3p24.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TOP2B
	Gene and transcription
Genbank	AB208879 [ ENTREZ ]
Genbank	AK296510 [ ENTREZ ]
Genbank	AK307450 [ ENTREZ ]
Genbank	AY309240 [ ENTREZ ]
Genbank	BC021863 [ ENTREZ ]
RefSeq	NM_001068 [ SRS ]    NM_001068 [ ENTREZ ]
RefSeq	AC_000046 [ SRS ]    AC_000046 [ ENTREZ ]
RefSeq	AC_000135 [ SRS ]    AC_000135 [ ENTREZ ]
RefSeq	NC_000003 [ SRS ]    NC_000003 [ ENTREZ ]
RefSeq	NT_022517 [ SRS ]    NT_022517 [ ENTREZ ]
RefSeq	NW_001838877 [ SRS ]    NW_001838877 [ ENTREZ ]
RefSeq	NW_921651 [ SRS ]    NW_921651 [ ENTREZ ]
AceView	TOP2B AceView - NCBI
Unigene	Hs.475733 [ SRS ]    Hs.475733 [ NCBI ]     HS475733 [ spliceNest ]
Fast-db	3098 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q02880 [ SRS]    Q02880 [ EXPASY ]     Q02880 [ INTERPRO ]     Q02880 [ UNIPROT ]
Prosite	PS00177 TOPOISOMERASE_II [ SRS ]    PS00177 TOPOISOMERASE_II [ Expasy ]
Interpro	IPR003594 ATP_bd_ATPase [ SRS ]    IPR003594 ATP_bd_ATPase [ EBI ]
Interpro	IPR012542 DTHCT [ SRS ]    IPR012542 DTHCT [ EBI ]
Interpro	IPR002205 Topo_IIA_A/C [ SRS ]    IPR002205 Topo_IIA_A/C [ EBI ]
Interpro	IPR013758 Topo_IIA_A/C_ab [ SRS ]    IPR013758 Topo_IIA_A/C_ab [ EBI ]
Interpro	IPR013757 Topo_IIA_A_a [ SRS ]    IPR013757 Topo_IIA_A_a [ EBI ]
Interpro	IPR001241 Topo_IIA_B/N [ SRS ]    IPR001241 Topo_IIA_B/N [ EBI ]
Interpro	IPR013759 Topo_IIA_B/N_ab [ SRS ]    IPR013759 Topo_IIA_B/N_ab [ EBI ]
Interpro	IPR013506 Topo_IIA_B_2 [ SRS ]    IPR013506 Topo_IIA_B_2 [ EBI ]
CluSTr	Q02880
Pfam	PF00204 DNA_gyraseB [ SRS ]    PF00204 DNA_gyraseB [ Sanger ]    pfam00204 [ NCBI-CDD ]
Pfam	PF00521 DNA_topoisoIV [ SRS ]    PF00521 DNA_topoisoIV [ Sanger ]    pfam00521 [ NCBI-CDD ]
Pfam	PF08070 DTHCT [ SRS ]    PF08070 DTHCT [ Sanger ]    pfam08070 [ NCBI-CDD ]
Pfam	PF02518 HATPase_c [ SRS ]    PF02518 HATPase_c [ Sanger ]    pfam02518 [ NCBI-CDD ]
Smart	SM00387 HATPase_c [EMBL]
Smart	SM00433 TOP2c [EMBL]
Smart	SM00434 TOP4c [EMBL]
Prodom	PD149633 DNA_gyrase_B[INRA-Toulouse]
Prodom	Q02880 TOP2B_HUMAN [ Domain structure ]   Q02880 TOP2B_HUMAN  [ sequences sharing at least 1 domain ]
Prodom	PD149633[INRA-Toulouse]
Prodom	Q02880 TOP2B_HUMAN [ Domain structure ]   Q02880 TOP2B_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	Q02880
HPRD	00537
	Protein Interaction databases
DIP	Q02880
IntAct	Q02880
	Polymorphism : SNP, mutations, diseases
OMIM	126431    [ map ]
GENECLINICS	126431
SNP	TOP2B [dbSNP-NCBI]
SNP	NM_001068 [SNP-NCI]
SNP	TOP2B [GeneSNPs - Utah]  TOP2B] [HGBASE - SRS]
HAPMAP	TOP2B [HAPMAP]
COSMIC	TOP2B [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	TOP2B
	General knowledge
Family Browser	TOP2B [UCSC Family Browser]
SOURCE	NM_001068
SMD	Hs.475733
SAGE	Hs.475733
Enzyme	5.99.1.3 [ Enzyme-Expasy ]   5.99.1.3 [ Enzyme-SRS ]   5.99.1.3 [ IntEnz-EBI ]   5.99.1.3 [ BRENDA ]   5.99.1.3 [ KEGG ]   5.99.1.3 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	heterochromatin [Amigo]  heterochromatin
GO	neuron migration [Amigo]  neuron migration
GO	chromatin binding [Amigo]  chromatin binding
GO	DNA topoisomerase (ATP-hydrolyzing) activity [Amigo]  DNA topoisomerase (ATP-hydrolyzing) activity
GO	protein kinase C binding [Amigo]  protein kinase C binding
GO	ATP binding [Amigo]  ATP binding
GO	nucleus [Amigo]  nucleus
GO	nucleoplasm [Amigo]  nucleoplasm
GO	chromosome [Amigo]  chromosome
GO	nucleolus [Amigo]  nucleolus
GO	cytoplasm [Amigo]  cytoplasm
GO	cytosol [Amigo]  cytosol
GO	DNA topological change [Amigo]  DNA topological change
GO	axonogenesis [Amigo]  axonogenesis
GO	protein C-terminus binding [Amigo]  protein C-terminus binding
GO	forebrain development [Amigo]  forebrain development
GO	histone deacetylase binding [Amigo]  histone deacetylase binding
GO	protein heterodimerization activity [Amigo]  protein heterodimerization activity
BIOCARTA	Control of Gene Expression by Vitamin D Receptor    [Genes]
PubGene	TOP2B
TreeFam	TOP2B
CTD	7155 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TOP2B Related clones (RZPD - Berlin)
	PubMed
PubMed	53 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 15:05:29 2008