TOP3B (topoisomerase (DNA) III beta)

Identity

Other names	FLJ39376
HGNC	TOP3B
Location	22q11.22
Location_base_pair	Starts at 20641403 and ends at 20667147 bp from pter (hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	TOP3B   11993
Entrez_Gene	TOP3B  8940  topoisomerase (DNA) III beta
	Cards
GeneCards	TOP3B
Ensembl	TOP3B [Search_View]   ENSG00000100038 [Gene_View]
Genatlas	TOP3B
GeneLynx	TOP3B
eGenome	TOP3B
euGene	8940
	Genomic and cartography
GoldenPath	TOP3B  -  22q11.22   chr22:20641403-20667147 -  22q11.22   [Description]    (hg18-March_2006)
Ensembl	TOP3B - 22q11.22 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TOP3B
	Gene and transcription
Genbank	AF017146 [ ENTREZ ]
Genbank	AF053082 [ ENTREZ ]
Genbank	AF070585 [ ENTREZ ]
Genbank	AF125216 [ ENTREZ ]
Genbank	AK096695 [ ENTREZ ]
RefSeq	NM_003935 [ SRS ]    NM_003935 [ ENTREZ ]
RefSeq	AC_000065 [ SRS ]    AC_000065 [ ENTREZ ]
RefSeq	AC_000154 [ SRS ]    AC_000154 [ ENTREZ ]
RefSeq	NC_000022 [ SRS ]    NC_000022 [ ENTREZ ]
RefSeq	NT_011520 [ SRS ]    NT_011520 [ ENTREZ ]
RefSeq	NW_001838745 [ SRS ]    NW_001838745 [ ENTREZ ]
RefSeq	NW_927628 [ SRS ]    NW_927628 [ ENTREZ ]
AceView	TOP3B AceView - NCBI
Unigene	Hs.436401 [ SRS ]    Hs.436401 [ NCBI ]     HS436401 [ spliceNest ]
Fast-db	2194 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O95985 [ SRS]    O95985 [ EXPASY ]     O95985 [ INTERPRO ]     O95985 [ UNIPROT ]
Prosite	PS00396 TOPOISOMERASE_I_PROK [ SRS ]    PS00396 TOPOISOMERASE_I_PROK [ Expasy ]
Interpro	IPR003601 Topo_IA_2 [ SRS ]    IPR003601 Topo_IA_2 [ EBI ]
Interpro	IPR013497 Topo_IA_cen [ SRS ]    IPR013497 Topo_IA_cen [ EBI ]
Interpro	IPR013824 Topo_IA_cen_sub1 [ SRS ]    IPR013824 Topo_IA_cen_sub1 [ EBI ]
Interpro	IPR013826 Topo_IA_cen_sub3 [ SRS ]    IPR013826 Topo_IA_cen_sub3 [ EBI ]
Interpro	IPR000380 Topo_IA_core [ SRS ]    IPR000380 Topo_IA_core [ EBI ]
Interpro	IPR003602 Topo_IA_DNA_bd [ SRS ]    IPR003602 Topo_IA_DNA_bd [ EBI ]
Interpro	IPR006171 Toprim_dom [ SRS ]    IPR006171 Toprim_dom [ EBI ]
Interpro	IPR006154 Toprim_sub [ SRS ]    IPR006154 Toprim_sub [ EBI ]
CluSTr	O95985
Pfam	PF01131 Topoisom_bac [ SRS ]    PF01131 Topoisom_bac [ Sanger ]    pfam01131 [ NCBI-CDD ]
Pfam	PF01751 Toprim [ SRS ]    PF01751 Toprim [ Sanger ]    pfam01751 [ NCBI-CDD ]
Smart	SM00437 TOP1Ac [EMBL]
Smart	SM00436 TOP1Bc [EMBL]
Smart	SM00493 TOPRIM [EMBL]
Blocks	O95985
HPRD	04662
	Protein Interaction databases
DIP	O95985
IntAct	O95985
	Polymorphism : SNP, mutations, diseases
OMIM	603582    [ map ]
GENECLINICS	603582
SNP	TOP3B [dbSNP-NCBI]
SNP	NM_003935 [SNP-NCI]
SNP	TOP3B [GeneSNPs - Utah]  TOP3B] [HGBASE - SRS]
HAPMAP	TOP3B [HAPMAP]
COSMIC	TOP3B [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	TOP3B
	General knowledge
Family Browser	TOP3B [UCSC Family Browser]
SOURCE	NM_003935
SMD	Hs.436401
SAGE	Hs.436401
Enzyme	5.99.1.2 [ Enzyme-Expasy ]   5.99.1.2 [ Enzyme-SRS ]   5.99.1.2 [ IntEnz-EBI ]   5.99.1.2 [ BRENDA ]   5.99.1.2 [ KEGG ]   5.99.1.2 [ WIT ]
GO	DNA topoisomerase type I activity [Amigo]  DNA topoisomerase type I activity
GO	protein binding [Amigo]  protein binding
GO	nucleus [Amigo]  nucleus
GO	chromosome [Amigo]  chromosome
GO	DNA topological change [Amigo]  DNA topological change
GO	DNA unwinding during replication [Amigo]  DNA unwinding during replication
PubGene	TOP3B
TreeFam	TOP3B
CTD	8940 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TOP3B Related clones (RZPD - Berlin)
	PubMed
PubMed	15 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 11 13:35:55 2008