TP73 (tumor protein p73)

Identity

Other names	P73
HGNC	TP73
Location	1p36.3
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	TP73   12003
Entrez_Gene	TP73  7161  tumor protein p73
	Cards
GeneCards	TP73
Ensembl	TP73 [Search_View]   ENSG00000078900 [Gene_View]
Genatlas	TP73
GeneLynx	TP73
eGenome	TP73
euGene	7161
	Genomic and cartography
GoldenPath	TP73  -  1p36.3   chr1:3597096-3640327 +  1p36.32   [Description]    (hg18-March_2006)
Ensembl	TP73 - 1p36.32 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TP73
	Gene and transcription
Genbank	AB055065 [ ENTREZ ]
Genbank	AB055066 [ ENTREZ ]
Genbank	AY040827 [ ENTREZ ]
Genbank	AY040828 [ ENTREZ ]
Genbank	AY040829 [ ENTREZ ]
RefSeq	NM_001126240 [ SRS ]    NM_001126240 [ ENTREZ ]
RefSeq	NM_001126241 [ SRS ]    NM_001126241 [ ENTREZ ]
RefSeq	NM_001126242 [ SRS ]    NM_001126242 [ ENTREZ ]
RefSeq	NM_005427 [ SRS ]    NM_005427 [ ENTREZ ]
RefSeq	AC_000044 [ SRS ]    AC_000044 [ ENTREZ ]
RefSeq	AC_000133 [ SRS ]    AC_000133 [ ENTREZ ]
RefSeq	NC_000001 [ SRS ]    NC_000001 [ ENTREZ ]
RefSeq	NT_004321 [ SRS ]    NT_004321 [ ENTREZ ]
RefSeq	NW_001838618 [ SRS ]    NW_001838618 [ ENTREZ ]
RefSeq	NW_923572 [ SRS ]    NW_923572 [ ENTREZ ]
AceView	TP73 AceView - NCBI
Unigene	Hs.697294 [ SRS ]    Hs.697294 [ NCBI ]     HS697294 [ spliceNest ]
Fast-db	1930 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O15350 [ SRS]    O15350 [ EXPASY ]     O15350 [ INTERPRO ]     O15350 [ UNIPROT ]
Prosite	PS00348 P53 [ SRS ]    PS00348 P53 [ Expasy ]
Interpro	IPR002117 p53 [ SRS ]    IPR002117 p53 [ EBI ]
Interpro	IPR011615 p53_DNA_bd [ SRS ]    IPR011615 p53_DNA_bd [ EBI ]
Interpro	IPR012346 p53_RUNT_DNA_bd [ SRS ]    IPR012346 p53_RUNT_DNA_bd [ EBI ]
Interpro	IPR010991 p53_tetrameristn [ SRS ]    IPR010991 p53_tetrameristn [ EBI ]
Interpro	IPR001660 SAM [ SRS ]    IPR001660 SAM [ EBI ]
Interpro	IPR011510 SAM_2 [ SRS ]    IPR011510 SAM_2 [ EBI ]
Interpro	IPR013761 SAM_type [ SRS ]    IPR013761 SAM_type [ EBI ]
Interpro	IPR015551 Trp53 [ SRS ]    IPR015551 Trp53 [ EBI ]
CluSTr	O15350
Pfam	PF00870 P53 [ SRS ]    PF00870 P53 [ Sanger ]    pfam00870 [ NCBI-CDD ]
Pfam	PF07710 P53_tetramer [ SRS ]    PF07710 P53_tetramer [ Sanger ]    pfam07710 [ NCBI-CDD ]
Pfam	PF07647 SAM_2 [ SRS ]    PF07647 SAM_2 [ Sanger ]    pfam07647 [ NCBI-CDD ]
Smart	SM00454 SAM [EMBL]
Prodom	PD002681 P53[INRA-Toulouse]
Prodom	O15350 P73_HUMAN [ Domain structure ]   O15350 P73_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	O15350
PDB	1COK [ SRS ]    1COK [ PdbSum ],   1COK [ IMB ]   1COK [ RSDB ]
PDB	1DXS [ SRS ]    1DXS [ PdbSum ],   1DXS [ IMB ]   1DXS [ RSDB ]
HPRD	03587
	Protein Interaction databases
DIP	O15350
IntAct	O15350
	Polymorphism : SNP, mutations, diseases
OMIM	601990    [ map ]
GENECLINICS	601990
SNP	TP73 [dbSNP-NCBI]
SNP	NM_001126240 [SNP-NCI]
SNP	NM_001126241 [SNP-NCI]
SNP	NM_001126242 [SNP-NCI]
SNP	NM_005427 [SNP-NCI]
SNP	TP73 [GeneSNPs - Utah]  TP73] [HGBASE - SRS]
HAPMAP	TP73 [HAPMAP]
COSMIC	TP73 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	TP73
	General knowledge
Family Browser	TP73 [UCSC Family Browser]
SOURCE	NM_001126240
SOURCE	NM_001126241
SOURCE	NM_001126242
SOURCE	NM_005427
SMD	Hs.697294
SAGE	Hs.697294
GO	response to tumor cell [Amigo]  response to tumor cell
GO	transcription factor activity [Amigo]  transcription factor activity
GO	protein binding [Amigo]  protein binding
GO	nucleus [Amigo]  nucleus
GO	mismatch repair [Amigo]  mismatch repair
GO	apoptosis [Amigo]  apoptosis
GO	zinc ion binding [Amigo]  zinc ion binding
GO	DNA damage response, signal transduction resulting in induction of apoptosis [Amigo]  DNA damage response, signal transduction resulting in induction of apoptosis
GO	negative regulation of cell growth [Amigo]  negative regulation of cell growth
GO	negative regulation of cell cycle [Amigo]  negative regulation of cell cycle
GO	positive regulation of transcription, DNA-dependent [Amigo]  positive regulation of transcription, DNA-dependent
GO	metal ion binding [Amigo]  metal ion binding
BIOCARTA	ATM Signaling Pathway    [Genes]
PubGene	TP73
TreeFam	TP73
CTD	7161 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TP73 Related clones (RZPD - Berlin)
	PubMed
PubMed	243 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Sep 29 18:26:42 2008