TPMT (thiopurine S-methyltransferase)

Identity

Other names	-
HGNC	TPMT
Location	6p22.3
Location_base_pair	Starts at 18236524 and ends at 18263353 bp from pter (hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	TPMT   12014
Entrez_Gene	TPMT  7172  thiopurine S-methyltransferase
	Cards
GeneCards	TPMT
Ensembl	TPMT [Search_View]   ENSG00000137364 [Gene_View]
Genatlas	TPMT
GeneLynx	TPMT
eGenome	TPMT
euGene	7172
	Genomic and cartography
GoldenPath	TPMT  -  6p22.3   chr6:18236524-18263353 -  6p22.3   [Description]    (hg18-March_2006)
Ensembl	TPMT - 6p22.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TPMT
	Gene and transcription
Genbank	AA746081 [ ENTREZ ]
Genbank	AA825975 [ ENTREZ ]
Genbank	AF021876 [ ENTREZ ]
Genbank	AF021877 [ ENTREZ ]
Genbank	AK310420 [ ENTREZ ]
RefSeq	NM_000367 [ SRS ]    NM_000367 [ ENTREZ ]
RefSeq	AC_000049 [ SRS ]    AC_000049 [ ENTREZ ]
RefSeq	AC_000138 [ SRS ]    AC_000138 [ ENTREZ ]
RefSeq	NC_000006 [ SRS ]    NC_000006 [ ENTREZ ]
RefSeq	NT_007592 [ SRS ]    NT_007592 [ ENTREZ ]
RefSeq	NW_001838973 [ SRS ]    NW_001838973 [ ENTREZ ]
RefSeq	NW_922984 [ SRS ]    NW_922984 [ ENTREZ ]
AceView	TPMT AceView - NCBI
Unigene	Hs.444319 [ SRS ]    Hs.444319 [ NCBI ]     HS444319 [ spliceNest ]
Fast-db	3093 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P51580 [ SRS]    P51580 [ EXPASY ]     P51580 [ INTERPRO ]     P51580 [ UNIPROT ]
Interpro	IPR008854 Thiopurine_S-MeTrfase [ SRS ]    IPR008854 Thiopurine_S-MeTrfase [ EBI ]
Interpro	IPR016822 Thiopurine_S-MeTrfase_sub [ SRS ]    IPR016822 Thiopurine_S-MeTrfase_sub [ EBI ]
CluSTr	P51580
Pfam	PF05724 TPMT [ SRS ]    PF05724 TPMT [ Sanger ]    pfam05724 [ NCBI-CDD ]
Blocks	P51580
PDB	2BZG [ SRS ]    2BZG [ PdbSum ],   2BZG [ IMB ]   2BZG [ RSDB ]
PDB	2H11 [ SRS ]    2H11 [ PdbSum ],   2H11 [ IMB ]   2H11 [ RSDB ]
HPRD	01760
	Protein Interaction databases
DIP	P51580
IntAct	P51580
	Polymorphism : SNP, mutations, diseases
OMIM	187680;610460    [ map ]
GENECLINICS	187680;610460
SNP	TPMT [dbSNP-NCBI]
SNP	NM_000367 [SNP-NCI]
SNP	TPMT [GeneSNPs - Utah]  TPMT] [HGBASE - SRS]
HAPMAP	TPMT [HAPMAP]
HGMD	TPMT
	General knowledge
Family Browser	TPMT [UCSC Family Browser]
SOURCE	NM_000367
SMD	Hs.444319
SAGE	Hs.444319
Enzyme	2.1.1.67 [ Enzyme-Expasy ]   2.1.1.67 [ Enzyme-SRS ]   2.1.1.67 [ IntEnz-EBI ]   2.1.1.67 [ BRENDA ]   2.1.1.67 [ KEGG ]   2.1.1.67 [ WIT ]
GO	cytoplasm [Amigo]  cytoplasm
GO	cytosol [Amigo]  cytosol
GO	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [Amigo]  nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO	thiopurine S-methyltransferase activity [Amigo]  thiopurine S-methyltransferase activity
GO	metabolic process [Amigo]  metabolic process
GO	methyltransferase activity [Amigo]  methyltransferase activity
GO	transferase activity [Amigo]  transferase activity
GO	S-adenosylhomocysteine metabolic process [Amigo]  S-adenosylhomocysteine metabolic process
GO	S-adenosylmethionine metabolic process [Amigo]  S-adenosylmethionine metabolic process
PubGene	TPMT
TreeFam	TPMT
CTD	7172 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TPMT Related clones (RZPD - Berlin)
	PubMed
PubMed	124 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 11 13:36:04 2008