TPO (thyroid peroxidase)

Identity

Other names	MSA
	TPX
HGNC	TPO
Location	2p25
Location_base_pair	Starts at 1396242 and ends at 1525502 bp from pter (hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	TPO   12015
Entrez_Gene	TPO  7173  thyroid peroxidase
	Cards
GeneCards	TPO
Ensembl	TPO [Search_View]   ENSG00000115705 [Gene_View]
Genatlas	TPO
GeneLynx	TPO
eGenome	TPO
euGene	7173
	Genomic and cartography
GoldenPath	TPO  -  2p25   chr2:1396242-1525502 +  2p25.3   [Description]    (hg18-March_2006)
Ensembl	TPO - 2p25.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TPO
	Gene and transcription
Genbank	AB208960 [ ENTREZ ]
Genbank	AF439430 [ ENTREZ ]
Genbank	AF533528 [ ENTREZ ]
Genbank	AF533529 [ ENTREZ ]
Genbank	AF533530 [ ENTREZ ]
RefSeq	NM_000547 [ SRS ]    NM_000547 [ ENTREZ ]
RefSeq	NM_175719 [ SRS ]    NM_175719 [ ENTREZ ]
RefSeq	NM_175721 [ SRS ]    NM_175721 [ ENTREZ ]
RefSeq	NM_175722 [ SRS ]    NM_175722 [ ENTREZ ]
RefSeq	AC_000045 [ SRS ]    AC_000045 [ ENTREZ ]
RefSeq	AC_000134 [ SRS ]    AC_000134 [ ENTREZ ]
RefSeq	NC_000002 [ SRS ]    NC_000002 [ ENTREZ ]
RefSeq	NT_022221 [ SRS ]    NT_022221 [ ENTREZ ]
RefSeq	NW_001838759 [ SRS ]    NW_001838759 [ ENTREZ ]
RefSeq	NW_927719 [ SRS ]    NW_927719 [ ENTREZ ]
AceView	TPO AceView - NCBI
Unigene	Hs.467554 [ SRS ]    Hs.467554 [ NCBI ]     HS467554 [ spliceNest ]
Fast-db	697 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P07202 [ SRS]    P07202 [ EXPASY ]     P07202 [ INTERPRO ]     P07202 [ UNIPROT ]
Prosite	PS00010 ASX_HYDROXYL [ SRS ]    PS00010 ASX_HYDROXYL [ Expasy ]
Prosite	PS00022 EGF_1 [ SRS ]    PS00022 EGF_1 [ Expasy ]
Prosite	PS01186 EGF_2 [ SRS ]    PS01186 EGF_2 [ Expasy ]
Prosite	PS50026 EGF_3 [ SRS ]    PS50026 EGF_3 [ Expasy ]
Prosite	PS01187 EGF_CA [ SRS ]    PS01187 EGF_CA [ Expasy ]
Prosite	PS00435 PEROXIDASE_1 [ SRS ]    PS00435 PEROXIDASE_1 [ Expasy ]
Prosite	PS00436 PEROXIDASE_2 [ SRS ]    PS00436 PEROXIDASE_2 [ Expasy ]
Prosite	PS50292 PEROXIDASE_3 [ SRS ]    PS50292 PEROXIDASE_3 [ Expasy ]
Prosite	PS50923 SUSHI [ SRS ]    PS50923 SUSHI [ Expasy ]
Interpro	IPR016060 Complement_control_module [ SRS ]    IPR016060 Complement_control_module [ EBI ]
Interpro	IPR000152 EGF-type_Asp/Asn_hydroxyl_CS [ SRS ]    IPR000152 EGF-type_Asp/Asn_hydroxyl_CS [ EBI ]
Interpro	IPR000742 EGF_3 [ SRS ]    IPR000742 EGF_3 [ EBI ]
Interpro	IPR001881 EGF_Ca_bd [ SRS ]    IPR001881 EGF_Ca_bd [ EBI ]
Interpro	IPR013091 EGF_Ca_bd_2 [ SRS ]    IPR013091 EGF_Ca_bd_2 [ EBI ]
Interpro	IPR013032 EGF_like_reg_CS [ SRS ]    IPR013032 EGF_like_reg_CS [ EBI ]
Interpro	IPR002007 Haem_peroxidase_animal [ SRS ]    IPR002007 Haem_peroxidase_animal [ EBI ]
Interpro	IPR002016 Haem_peroxidase_pln/fun/bac [ SRS ]    IPR002016 Haem_peroxidase_pln/fun/bac [ EBI ]
Interpro	IPR000436 Sushi_SCR_CCP [ SRS ]    IPR000436 Sushi_SCR_CCP [ EBI ]
CluSTr	P07202
Pfam	PF03098 An_peroxidase [ SRS ]    PF03098 An_peroxidase [ Sanger ]    pfam03098 [ NCBI-CDD ]
Pfam	PF07645 EGF_CA [ SRS ]    PF07645 EGF_CA [ Sanger ]    pfam07645 [ NCBI-CDD ]
Pfam	PF00084 Sushi [ SRS ]    PF00084 Sushi [ Sanger ]    pfam00084 [ NCBI-CDD ]
Smart	SM00032 CCP [EMBL]
Smart	SM00179 EGF_CA [EMBL]
Blocks	P07202
HPRD	06000
	Protein Interaction databases
DIP	P07202
IntAct	P07202
	Polymorphism : SNP, mutations, diseases
OMIM	274500;606765    [ map ]
GENECLINICS	274500;606765
SNP	TPO [dbSNP-NCBI]
SNP	NM_000547 [SNP-NCI]
SNP	NM_175719 [SNP-NCI]
SNP	NM_175721 [SNP-NCI]
SNP	NM_175722 [SNP-NCI]
SNP	TPO [GeneSNPs - Utah]  TPO] [HGBASE - SRS]
HAPMAP	TPO [HAPMAP]
COSMIC	TPO [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	TPO
	General knowledge
Family Browser	TPO [UCSC Family Browser]
SOURCE	NM_000547
SOURCE	NM_175719
SOURCE	NM_175721
SOURCE	NM_175722
SMD	Hs.467554
SAGE	Hs.467554
Enzyme	1.11.1.8 [ Enzyme-Expasy ]   1.11.1.8 [ Enzyme-SRS ]   1.11.1.8 [ IntEnz-EBI ]   1.11.1.8 [ BRENDA ]   1.11.1.8 [ KEGG ]   1.11.1.8 [ WIT ]
GO	iodide peroxidase activity [Amigo]  iodide peroxidase activity
GO	peroxidase activity [Amigo]  peroxidase activity
GO	peroxidase activity [Amigo]  peroxidase activity
GO	iron ion binding [Amigo]  iron ion binding
GO	calcium ion binding [Amigo]  calcium ion binding
GO	cellular_component [Amigo]  cellular_component
GO	integral to plasma membrane [Amigo]  integral to plasma membrane
GO	thyroid hormone generation [Amigo]  thyroid hormone generation
GO	response to oxidative stress [Amigo]  response to oxidative stress
GO	membrane [Amigo]  membrane
GO	oxidoreductase activity [Amigo]  oxidoreductase activity
GO	heme binding [Amigo]  heme binding
GO	hormone biosynthetic process [Amigo]  hormone biosynthetic process
GO	hydrogen peroxide catabolic process [Amigo]  hydrogen peroxide catabolic process
GO	oxidation reduction [Amigo]  oxidation reduction
KEGG	Tyrosine metabolism
KEGG	Phenylalanine metabolism
KEGG	Methane metabolism
KEGG	Stilbene, coumarine and lignin biosynthesis
KEGG	Cytokine-cytokine receptor interaction
KEGG	Jak-STAT signaling pathway
KEGG	Hematopoietic cell lineage
PubGene	TPO
TreeFam	TPO
CTD	7173 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TPO Related clones (RZPD - Berlin)
	PubMed
PubMed	70 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 11 13:36:04 2008